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2023 Vol. 53, No. 4 Published: 2023-04-25   259 Fibroblast growth factor 1 alleviates acetaminophen-induced acute liver injury in mice via improving mitochondrial oxidative stress PENG Ziying, NAN Yan, XIE Xianhai, LI Xiaoxiao, GAO Ling, ZHANG Lei, YAO Ruina, YING Lei, WANG Yang DOI: 10.3969/j.issn.2095-9400.2023.04.001 Objective: To explore the function and mechanism of fibroblast growth factor 1 (FGF1) on alleviating acute liver injury induced by acetaminophen (APAP) in mice. Methods: ①C57BL/6J mice were randomly divided as the control group, APAP 3 h group, APAP 6 h group, APAP 12 h group, and APAP 24 h group. After intraperitoneal injection of 500 mg/kg APAP, the mice were killed at the corresponding time points.The most significant time point of acute liver injury in APAP mice was determined by observing the content of reactive oxygen species and the number of inflammatory cells using liver DHE staining and F4/80 staining.②C57BL/6J mice were randomly divided as the control group, APAP group, APAP+FGF1 1 mg/kg group,APAP+FGF1 2 mg/kg group, and APAP+FGF1 5 mg/kg group. After 1 h of modeling with a 500 mg/kg dose of APAP, the corresponding dose of FGF1 was intraperitoneally injected. The mice were euthanized 6 h after modeling. The damage area was observed by HE staining of the liver. Liver function level was detected by ALT and AST kits. Oxidative stress levels of the liver were detected by DHE straining, MDA and SOD kits, and gene expression of CAT, SOD2 and NRF2. Inflammation level of the liver was detected by F4/80 staining, and gene expression of CCL5, TNFα and IL-6. Based on the above results, the optimal FGF1 dose for the treatment of acute liver injury induced by APAP was determined; ③C57BL/6J mice were randomly divided as the control group, 3 h APAP group, 3 h APAP+FGF1 group, 6 h APAP group, 6 h APAP+FGF1 group. After modeling with a 500 mg/kg dose of APAP for 1 h, a dose of 2 mg/kg FGF1 was administered intraperitoneally. The mice were euthanized at the corresponding time points after modeling. Then the reagent kit was used to detect ATP content,and Western blot was used to detect the relative expression level of Total Oxphos (CV-ATP5A, CIII-UQCRC2,CIV-MTCO1, CII-SDHB, and CII-NDUFB8) and 3NT proteins. Based on the above results, the mechanism of FGF1 alleviating acute liver injury induced by APAP was investigated; ④HepG2 cells were treated with different concentrations of APAP (0, 1, 5, 10, 15, 20, 40 and 60 mmol/L) for 24 h, and the cell activity was measured by cytotoxicity assay (CCK-8); ⑤In MEM basic culture medium containing 20 mmol/L APAP, different concentrations of FGF1 were added, resulting in FGF1 final concentrations of 0, 0.5, 1, 5 and 10 mg/mL. After 24 h of treatment, the cell activity was detected by CCK-8. Results: ①In acute liver injury induced by APAP in mice,the level of reactive oxygen species significantly increased at 3 h after modeling and reached its peak at 6 h; The number of inflammatory cells significantly increased and reached its maximum at 6 h, and began to decrease at 12 and 24 h; ②In acute liver injury induced by APAP in mice, the expression level of FGF1 protein was significantly reduced (P<0.01); ③After treatment with different doses of FGF1, HE staining of the liver showed a reduction in the area of damage, and significant downregulation of serum ALT and AST; DHE staining of the liver revealed a significant decrease in reactive oxygen species level, downregulation of MDA, upregulation of SOD, and upregulation of gene expression of CAT, SOD2 and NRF2 (P<0.01); F4/80 staining of the liver revealed a significant decrease in the number of inflammatory cells, and downregulation of gene expression of CCL5, TNF α and IL-6 (P<0.01). The overall results showed that the best treatment effect was achieved at a dose of 2 mg/kg; ④APAP at concentrations of 15, 20, 40 and 60 mmol/L can significantly reduce HepG2 cell activity (CCK-8 experiment), and different doses of FGF1 can upregulate the cell activity in HepG2 cell damage caused by 20 mmol/L APAP (P<0.01); ⑤FGF1 can significantly upregulate the ATP content of the liver in mice at 3 h and 6 h liver injury induced by APAP (P<0.05), upregulate the expression of 6 h CIV-MTCO1, CII-SDHB and CINDUFB8 proteins in the Total Oxphos complex, and downregulate the expression of 3 h and 6 h 3-NT proteins (P<0.05). Conclusion: FGF1 can alleviate acute APAP-induced liver injury in mice via inhibiting mitochondrial oxidative stress. 2023 Vol. 53 (4): 259-268 [Abstract] ( 359 ) HTML (1 KB)  PDF (2193 KB)  ( 715 ) 269 The protective effect of indoleamine 2, 3-dioxygenase 1 on the acute intestinal radiation injury LAN Yanli, PI Wenhu, MEI Dan, YANG Haihua, KONG Fengming DOI: 10.3969/j.issn.2095-9400.2023.04.002 Objective: To investigate the protective mechanism of indoleamine 2, 3-dioxygenase 1 (IDO1) against radiation-induced acute intestinal injury. Methods: The expression level of IDO1 gene in colorectal cancer tissues and normal intestinal tissues were analyzed based on the TCGA and GTEX database. CRISPR/Cas9 technology was employed to delete the promoter and first exon sequences of IDO1 gene in IEC-6 cell for generating the IDO1 knockout (IDO1-/-, IDO1-KO) cell line, then wild type (WT) and knockout (IDO1-KO) IEC-6 cells were given radiation treatment. What’s more, C57BL/6 wild-type mice and IDO1 knockout (IDO1-/-) mice were given abdominal X-ray irradiation to establish radiation-induced intestinal damage model. Western blot was used to determine the IDO1 and epithelial tight junction proteins Claudin 1, Occludin, ZO-1 levels in cells and mouse intestinal tissues before and after radiation. Results: IDO1 gene was expressed in colon cancer, rectal cancer, and normal intestinal tissues. Compared with normal tissues, the expression level of IDO1 gene in cancer cells was higher, based on the TCGA and GTEX database analysis (P<0.05). Western blot indicated that IDO1 expressed in IEC-6 cells and mouse intestinal tissues in vitro and in vivo. The protein levels of IDO1, Claudin 1, Occludin and ZO-1 showed significant changes after irradiation. The expression level of IDO1 increased significantly while tight junction protein Claudin 1, Occludin and ZO-1 decreased after radiation in IEC-6 cells and mouse intestinal tissues (P<0.05). Interestingly, the tight junction proteins decreased even more in IDO1-KO IEC-6 cells and mouse intestinal tissues (P<0.05). Conclusion: IDO1 has protective effect on intestinal radiation injury, which may be achieved by promoting the tight junctions of intestinal epithelial cells. 2023 Vol. 53 (4): 269-275,284 [Abstract] ( 266 ) HTML (1 KB)  PDF (2307 KB)  ( 610 ) 276 The establishment of a clinico-histopathological predictive model for the risk of cervical lymph node metastasis in papillary thyroid carcinoma LIN Qiongqiong, ZHAO Zhiguang, ZHUANG Xiaoping,HUANG Long, QIN Haide, RUAN Honglian DOI: 10.3969/j.issn.2095-9400.2023.04.003 Objective: To explore the risk factors of cervical lymph node metastasis in papillary thyroid carcinoma (PTC), and to construct a predictive model to evaluate the risk of cervical lymph node metastasis (CLNM) in PTC. Methods: A total of 675 patients diagnosed with PTC from April 2020 to July 2022 in our hospital were included. Univariate and multivariate logistic regression analyses were performed to screen out the independent risk factors of cervical lymph node metastasis in PTC. Further more, 70% of the patients were randomly selected for training set (n=474) at a ratio of 7:3, and 30% of patients were selected for validation set (n=201). Then the prediction model was constructed in the training set and validated in the validation dataset. The nomogram was drawn to visualize the model. The receiver operating characteristic (ROC) curves, calibration plot and the decision curve analysis (DCA) were plotted to evaluate the discriminatory ability, calibration and clinical value of the prediction model, respectively. Results: Among 675 patients with PTC, 212 (31.4%) of the patients presented cervical lymph node metastasis. In the multivariate Logistic regression analyses of the risk factors, six variables including age < 45 years, bilaterality, multifocality (≥3 nodules), tumor size > 1 cm,vascular invasion and capsular invasion were turned out to be the risk predictors for CLNM. We developed a visual nomogram based on the predictors that could be used to assess the risk of CLNM in PTC. The model could predict the risk of CLNM, with area under curve (AUC) of 0.787 (95%CI=0.741-0.834) in the training set and AUC of 0.720 (95%CI=0.644-0.796) in the validation set. The DCA showed that the net benefit of nomogram was high when the threshold probability was between 0.2-0.9. Conclusion: The predictive model which is based on risk factors aged < 45 years, bilaterality, multifocality (≥3 nodules), tumor size > 1 cm, vascular invasion and capsular invasion, is confirmed to be helpful to predict the risk of cervical lymph node metastasis in papillary thyroid carcinoma. 2023 Vol. 53 (4): 276-284 [Abstract] ( 323 ) HTML (1 KB)  PDF (1763 KB)  ( 719 ) 285 Metabonomics analysis of intravitreal injection of anti-vascular endothelial growth factor drugs in the treatment of macular edema secondary to branch retinal vein occlusion SUN Yining, YANG Chun,HUANG Ying, GE Lina, JIANG Dan, LIN Bing DOI: 10.3969/j.issn.2095-9400.2023.04.004 Objective: To investigate the intraocular metabolic changes in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) treated with intravitreal injection of vascular endothelial growth factor antagonist (anti-VEGF). Methods: The aqueous humor samples of 20 patients with ME secondary to BRVO were collected from Eye Hospital of Wenzhou Medical University during January 2021 to June 2021,before anti-VEGF treatment and 1 month after treatment, which were analyzed by liquid chromatography/mass spectrometry (LC-MS/MS) technology to detect metabolites, and metabolites were screened and functionally annotated by principal component analysis (PCA), differential metabolite analysis and pathway enrichment analysis. Results: After 1 month of anti-VEGF treatment, the central macular thickness of all ME secondary to BRVO patients was decreased with statistically significance (P<0.05). PCA results showed that metabolites of aqueous humor in patients with ME secondary to BRVO were significantly different from those before treatment.An analysis of differential metabolites found that the content of 4-Oxo-2-nonenal in the aqueous humor of patients after treatment was significantly increased (P<0.05), while palmitoyl lysophosphatidylcholine PC (16:0),7-ene and the contents of metabolites such as chol(ster)alkanol and PC[20:4(8Z, 11Z, 14Z, 17Z)/P-18:0] were significantly decreased (P<0.05). The pathway enrichment analysis showed that metabolites with reduced content were mainly involved in biological processes such as glycerophospholipid metabolism, α-linoleic acid metabolism and linolenic acid metabolism (P<0.05). Conclusion: ME secondary to BRVO patients showed significant changes in the intraocular metabolism after anti-VEGF treatment, with significant decrease in lipid metabolism. 2023 Vol. 53 (4): 285-290 [Abstract] ( 254 ) HTML (1 KB)  PDF (1813 KB)  ( 532 ) 291 AR-A014418 inhibits the expression of SOX2 and promotes the sensitivity of chondrosarcoma to cisplatin LIU Fanrong, TENG Honglin, XIAO Jianru DOI: 10.3969/j.issn.2095-9400.2023.04.005 Objective: To investigate the effect of GSK3β gene on human chondrosarcoma cell lines HCS 2/8 and SW 1353 by cell experiments. Methods: CCK-8 and colony formation assay were used to detect cell proliferation ability; Transwell assay was used to detect cell invasion ability; wound-healing assay was used to detect cell migration ability; Western blot was used to detect changes of SOX2 in cells; combination experiments were made to verify the effect of AR-A014418 combined with cisplatin. Results: Knockdown of GSK3β significantly inhibited the proliferation and invasion ability of chondrosarcoma (P<0.05). With GSK3β knockdown, the protein expression of SOX2 in cells decreased (P<0.05), and its mRNA level did not change significantly (P>0.05). AR-A014418 could effectively inhibit the expression of SOX2 in CS cells, and the combination of AR and cisplatin produced significant effect. Conclusion: Knockdown of GSK3β can inhibit the protein expression of SOX2 and promote the sensitivity of chondrosarcoma to chemotherapy. As a specific inhibitor of GSK3β, AR-A014418 has the function of killing chondrosarcoma cells, which has good combination effect with cisplatin. 2023 Vol. 53 (4): 291-297,304 [Abstract] ( 260 ) HTML (1 KB)  PDF (2547 KB)  ( 604 ) 298 Analysis of current situation and influencing factors of HIV-related psychological distress for HIV/AIDS patients who received antiretroviral therapy MA Haiqi, ZHAI Huimin, LI Bing, LI Juan, LUO Jiahui DOI: 10.3969/j.issn.2095-9400.2023.04.006 Objective: To investigate the current status and influence factors of HIV-related psychological distress (HRPD) among HIV/AIDS patients who received antiretroviral therapy treatment (ART). Methods:A convenience sample of 765 PLWHA was recruited relying on HIV/AIDS prevention and control social organization in Beijing between March 2022 and June 2022, and they were surveyed online by using a general data questionnaire and HIV-related psychological distress scale. The influencing factors were analyzed by Chisquare,Fisher’s exact probability method and logistic regression. Results: A total of 765 valid subjects were included in this study, with the detection rate of HRPD being 83.27%. Logistic regression analysis showed that no fixed work (OR=5.004, 95%CI=1.867-13.410, P=0.001), receiving ART for 1-3 years (OR=2.613, 95%CI=1.354-5.044, P=0.004) and not taking medication on time (OR=31.277, 95%CI=4.143-236.092, P=0.001) were risk factors for HRPD, while marriage (OR=0.320, 95%CI=0.187-0.550, P<0.001), adhering to condom use (OR=0.267, 95%CI=0.127-0.563, P=0.001), long time for diagnosis (OR=0.115, 95%CI=0.024-0.550, P=0.007),and high monthly income (>10 000 yuan) (OR=0.265, 95%CI=0.095-0.737, P=0.011) were protective factors.Conclusion: HRPD is common among HIV/AIDS patients who received ART, which is of high prevalence. It is suggested that healthcare workers should pay attention to the HRPD evaluation and provide timely intervention for patients with risk factors so as to improve their-living quality. 2023 Vol. 53 (4): 298-304 [Abstract] ( 370 ) HTML (1 KB)  PDF (1411 KB)  ( 680 ) 305 Analysis of resistant genetic mutations and characteristics of multidrug-resistant/rifampicin-resistant Mycobacterium tuberculosis in Wenzhou WU Lianpeng, XU Ke, HE Guiqing DOI: 10.3969/j.issn.2095-9400.2023.04.007 Objective: To analyze by whole genome sequencing (WGS) the drug resistance of multi-drug resistant/rifampicin-resistant Mycobacterium tuberculosis (MDR/RR-MTB) in Wenzhou in order to provide reference for the prevention and treatment of drug-resistant tuberculosis. Methods: The strains and clinical data of 54 patients with MDR/RR-TB treated in Wenzhou Central Hospital from January 2021 to September 2022 were collected and WGS was performed. The drug resistance of strains to 15 kinds of anti-tuberculosis drugs was analyzed. Simultaneously, a string diagram of bacterial resistance and a heat map were used to visualize drug resistance spectrum of all strains and pre-XDR-MTB/XDR-MTB strains, respectively. Results: Of 54 patients,75.93% were male and 50.00% over 45 years old; Wenzhou local residents accounted for 83.33%, non-fixed occupation 92.59%, and retreatment accounted for 40.74% of the treatment types. There was significant difference in sex, age, household registration and occupation (P<0.05), but there was no significant difference in the type of treatment (P>0.05). The drug resistance rate of 54 strains to drugs ranking from high to low was rifampicin (100.00%, 54/54), isoniazid (83.33%, 45/54), streptomycin (50.00%, 27/54), ethambutol (38.89%, 21/54), pyrazinamide (35.19%, 19/54), fluoroquinolones (24.07%, 13/54), prothionamide (24.07%, 13/54), and kanamycin (9.26%, 5/54), amikacin (9.26%, 5/54), capreomycin (9.26%, 5/54), para-aminosalicylic acid (7.41%, 4/54), linezolide (1.85%, 1/54), did not produce resistance to bedaquiline, cycloserine and chlorfazimine. A total of 65 types of gene mutations were detected, and mutations were most common in katG_S315T (77.78%, 35/45), rpoB_S450L (48.15%, 26/54), embB_M306V (52.38%, 11/21),rpsL_K43R (77.78%, 21/27), and gyrA_D94G (30.77%, 4/13). There were 3 XDR-TB strains (5.56%, 3/54) and 10 Pre-XDR-TB strains (18.52%, 10/54) were detected. Conclusion: Most of the MDR/RR-TB patients in Wenzhou are local middle-aged and elderly men with no fixed occupation, and the proportion of retreatment is high. The resistance rate of the strains to first-line anti-tuberculosis drugs, fluoroquinolones and prothionamide is high, mainly to katG, rpoB, embB, rpsL, pncA and gyrA gene mutations, but low to berdaquinoline, linezolid, cycloserine and chlorfazimine. The proportion of Pre-XDR-TB in MDR/RR-TB is high, so clinical treatment should refer to the results of drug sensitivity test for the sake of reasonable drug use. 2023 Vol. 53 (4): 305-310 [Abstract] ( 299 ) HTML (1 KB)  PDF (1568 KB)  ( 462 ) 311 Application of hazard vulnerability analysis to improve nursing emergency management in inpatient areas ZHOU Yufeng, FENG Xiaofang. DOI: 10.3969/j.issn.2095-9400.2023.04.008 Objective: To use hazard vulnerability analysis to evaluate the nursing risk in inpatient areas of a tertiary Class A hospital, and to formulate emergency plans for high-risk links, so as to improve the nursing emergency response ability. Methods: Based on the literature review of in-hospital nursing adverse events in recent 3 years, the members of Nursing Safety and Quality Committee used brainstorming to screen and determine risk indicators, and the Kaiser model assessment tool to calculate the hazard risk values and rank them. Results:The nursing management risk index system included 7 items of management risk (A), which refers to service management, 5 items of key link risk (B), 7 items of patient accident risk (C), 1 item of support system risk (D),and 1 item of nurse-related risk (E). The top 5 indicators and hazard risk values ranked as follows: C1 pulmonary embolism (58.33%), C3 falling/falling from bed (56.02%), C4 cardiac arrest events (53.82%), C6 aspiration/asphyxia (52.86%), and A1 outbreak of hospital infection (51.68%). Conclusion: Hazard vulnerability analysis is an important means of hospital emergency management. Managers should dynamically assess the nursing management risks in inpatient areas, take effective preventive measures for high-risk events, carry out emergency drills and continuously improve the early risk warning mechanism. The safety of patients is ensured only when the nursing emergency management is improved. 2023 Vol. 53 (4): 311-314,318 [Abstract] ( 246 ) HTML (1 KB)  PDF (1463 KB)  ( 547 ) 315 Nursing management based on PDCA to reduce the incidence of PET/CT imaging agent extravasation and its application effect ZHANG Xiuyun, JI Xiaowei, HUANG Renyi, YIN Weiwei DOI: 10.3969/j.issn.2095-9400.2023.04.009 Objective: To explore the effect of PDCA management on reducing the incidence of PET/CT imaging agent extravasation. Methods: A total of 939 patients who underwent PET/CT examination in the First Affiliated Hospital of Wenzhou Medical University from March 1, 2022 to March 31, 2022 were selected as the control group, and a total of 1905 patients who underwent PET/CT examination from October 1, 2022 to November 30, 2022 were selected as the experimental group. The traditional nursing process was carried out in the control group while the traditional nursing process plus PDCA management process transformation was performed in the experimental group. The incidence and severity of extravasation of imaging agents were compared between the two groups. Results: There were 13 cases of imaging agent extravasation in the control group (1.38%), and 11 cases in the experimental group (0.58%), with the incidence rate of imaging agent extravasation significantly lower in the experimental group than that in control group (P<0.05). The severity of imaging agent extravasation in the experimental group was lower than that in the control group (P<0.05). Conclusion: PDCA management can effectively reduce the incidence of PET/CT imaging agent extravasation and improve the compliance and nursing satisfaction of patients. 2023 Vol. 53 (4): 315-318 [Abstract] ( 220 ) HTML (1 KB)  PDF (1438 KB)  ( 566 ) 319 Application of ultrasonic vibration combined with multi enzyme solution in centralized cleaning of instruments in stomatological hospitals WANG Huimin, FAN Xiaolan. DOI: 10.3969/j.issn.2095-9400.2023.04.010 Objective: To explore the application effect of ultrasonic vibration combined with multi enzyme solution in centralized cleaning of instruments in stomatological hospitals. Methods: From March to May 2022,428 pieces of various instruments routinely used in Stomatological Hospital of Wenzhou Medical University were collected and divided as the control group and the test group by a random number table method, with 214 pieces in each group. The control group was pre-cleaned with multi enzyme solution, while the test group was pre-cleaned with ultrasound vibration combined with multi enzyme solution. The cleaning quality and qualified bacteriological detection after cleaning were compared between the two groups. Results: The qualified rate was higher in the experimental group after cleaning the instruments than that in the control group in magnifying glass test, adenosine triphophate fluorescence test and naked eye test (98.13% vs. 93.93%, 94.39% vs. 87.38%,99.53% vs. 96.73%) with significant difference (P<0.05). The eligible rate of bacteriological testing in the test group was higher than that in the control group immediately, 30 minutes, and 2 hours after instrument cleaning (99.07% vs. 95.79%, 97.20% vs. 92.06%, 92.99% vs. 86.92%), with significant difference (P<0.05). Conclusion:The application of ultrasonic vibration combined with multi enzyme solution in the centralized cleaning of instruments in stomatological hospitals can effectively remove residual substances, improve the cleaning qualification rate, and enhance the sterilization effect. 2023 Vol. 53 (4): 319-321 [Abstract] ( 256 ) HTML (1 KB)  PDF (1381 KB)  ( 817 ) 331 The influence of common inner group identity at different social distances on aggressive behavior in doctor-patient disputes BI Yaxuan, DING Chuan, WANG Pei DOI: 10.3969/j.issn.2095-9400.2023.04.014 Objective: To examine the influence of aggression caused by the threat of the common group identification at different social distances. Methods: Taking doctor-patient disputes event as experimental materials,the index of aggression was obtained by competitive response paradigm and implicit association paradigm, and independent sample t-test was used to analyze the differences of aggression at different social distances. Results:The common group identity with different social distances regulated the implicit aggression caused by the doctorpatient intergroup threat: when the social distance was far, the implicit aggression was significantly enhanced [t(58)=2.59, P=0.012]. Conclusion: Establishing a common inner group identity between doctors and patients helps to improve the doctor-patient relationship. Common internal group identity with close social distance will significantly weaken the aggression caused by inter-group threat. 2023 Vol. 53 (4): 331-334 [Abstract] ( 238 ) HTML (1 KB)  PDF (1414 KB)  ( 531 ) 335 “Medical Service All in One”: exploration and practice of a new intelligent hospital service model based on the people-centered concept ZHANG Yu, GAO Zhihong, SUN Zhen, HAO Haibin, CHEN Sanze, WANG Meihao DOI: 10.3969/j.issn.2095-9400.2023.04.015 Objective: With the development of society and improvement of people’s living standards,people have higher requirements for medical experience. The author follows the development concept of “putting the people at the center” as the research perspective, and analyzes the new smart service model of “Medical Service All in One” at the First Affiliated Hospital of Wenzhou Medical University from multiple dimensions such as construction, application, and results. This model integrates humanistic care and digital reform methods,optimizes the original medical treatment process, transforms “passive” service into “active” one, and combines online and offline integrated homogeneous management and services, so that the concept of “visit once at most” to see the doctor is implemented. Accomplishments have been achieved, which may provide reference for medical institutions in the construction of intelligent medical services. 2023 Vol. 53 (4): 335-339 [Abstract] ( 275 ) HTML (1 KB)  PDF (1617 KB)  ( 803 ) 340 Quality improvement in the degree awarding under “Double First-Class” initiative: A case study of Wenzhou Medical University ZHOU Jianguo, WANG Jiaozhi, CHEN Li, WU Maohua, HUANG Ping,XIAO Jian, ZHANG Yi DOI: 10.3969/j.issn.2095-9400.2023.04.016 The new round of “Double First-Class” Initiative highlights the significance of cultivating firstclass talents. Graduate study, as the highest level of our education system, is not only an essential element of the “Double First-Class” construction but also a key representation of national core competitive power. Therefore,improving the quality of degree awarding becomes the most urgent mission of graduate education and its development. There are many deficiencies in the current quality of graduate degree awarding, Wenzhou Medical University has made some achievements in improving the graduate degree awarding quality. This article, taking Wenzhou Medical University for an example, analyzes its quality control system for graduate degree awarding from the perspective of institutional improvement, curriculum development, process management, mentor team construction and other ways, with an aim to providing some practical reference for other local universities to carry out high-quality development of graduate education. 2023 Vol. 53 (4): 340-344 [Abstract] ( 274 ) HTML (1 KB)  PDF (1427 KB)  ( 590 )

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