温州医科大学学报
 
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2022 Vol. 52, No. 5
Published: 2022-05-25
 
 
345 Establishment and identification of acute hepatitis animal model infected by murine cytomegalovirus in C57BL/6 mice
RUAN Yufei, LIU Qi, WU Bo, XU Zhiyong, CHEN Ke, JIANG Minzhi, ZHANG Junling,YU Jinsheng, CHEN Yiping.
DOI: 10.3969/j.issn.2095-9400.2022.05.001
Objective: To establishe the acute hepatitis model of C57BL/6 mouse infected with murine cytomegalovirus (MCMV) and analyze its infectious characteristics so as to identify the model. Methods: Twentyfour C57BL/6 mice were randomized to the negative control group and virus infection group (n=12 in each). Murine cytomegalovirus (MCMV) suspension 1.0×106 PFU (200 μL) was intraperitoneally injected in the virus infection group mice, and an equivalent volume of mouse embryonic fibroblast (MEF) suspension in the negative control group. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested on day 3 and day 7 after infection. Meanwhile, virus isolation, histopathological analysis, detection of MCMV IE and M55 genes, interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) were performed.Results: In virus infection group, all the liver homogenates were positive for virus isolation and the incidence of hepatitis was 100%. The pathological changes of hepatitis occurred on the 3rd day after infection. Compared with the negative control group, the levels of serum ALT and AST in virus infected group were significantly increased (P<0.01). Focal necroinflammatory lesions were observed in the liver of the virus infected group on day 3 of
hematoxylin-eosin staining, which lasted until day 7. Ishak score was significantly higher than that of the negative control group (P<0.01). MCMV IE and M55 genes were detectable in liver tissue on day 3 after infection, and the IE gene was still detected on day 7 after infection. The mRNA expression of inflammatory cytokines, IL-6, TNF-α and IL-1β were significantly increased on day 3 and day 7 after infection (P<0.05). Conclusion: The acute hepatitis model infected with MCMV in C57BL/6 mice was established successfully, and the infection is mainlymanifested in the early stage of acute infection.
2022 Vol. 52 (5): 345-351,357 [Abstract] ( 733 ) HTML (1 KB)  PDF (2531 KB)  ( 819 )
352 The pathogenic mechanism of inherited protein C deficiency caused by Ala333Thr mutation
YU Xiaomin,CHANG Guolin, ZHENG Yiyang, CHEN Cheng, TANG Shiyi, WU Xinyuan, LYU Jia, LIN Xiangyang, ZHU Liqing.
DOI: 10.3969/j.issn.2095-9400.2022.05.002
Objective: To investigate the mechanism of inherited protein C deficiency (IPCD) caused by the mutation of protein C (PC) p.Ala333Thr. Methods: Amino acid multiple sequence alignment tool T-Coffee was used to evaluate the conservatism of mutant amino acid sites, and PolyPhen-2 was used to predict the harmfulness of mutations to the structure and the function of PC. The mutant PC plasmid and the wild type PC plasmid were constructed by QuickMutationTM mutation kit and transfected into HEK-293T cells. The mRNA level was detected, using real-time quantitative polymerase chain reaction (RT-qPCR) after 24 h transfection. The intracellular and extracellular protein level of PC was detected by Western blot and ELISA, respectively. Immunofluorescence was used to label the distribution of PC and fluorescent dyes were used to label endoplasmic reticulum (ER) and Golgi apparatus (GA) in HEK-293T cells. Results: The results of multiple sequence alignment showed that the Ala333 locus of PC was not conservative, and the p.Ala333Thr mutation score of PC was 0.763 by PolyPhen-2.The transcriptional level of mutant PROC gene was not significantly different from that of the wild type. The expression level of intracellular and extracellular PC of mutant PROC gene was significantly lower than that of the wild type. Immunofluorescence showed that wild type PC was distributed both in ER and GA, while mutant PC was mainly distributed in ER and only a small amount entered GA. Conclusion: The PC p.Ala333Thr mutation causes the misfolding and processing defect of PC, which induces the low expression of extracellular PC and results in the occurrence of IPCD.
2022 Vol. 52 (5): 352-357 [Abstract] ( 483 ) HTML (1 KB)  PDF (1865 KB)  ( 636 )
358 Mechanism of allicin in enhancing radiosensitivity of non-small cell lung cancer A549 cells via miR-486-5p/KDM5B axis
JIANG Yiling, YU Hongjin, ZHANG Ningbo, CHEN Cheng
DOI: 10.3969/j.issn.2095-9400.2022.05.003
Objective: To investigate the effect of allicin on the radiosensitivity of non-small cell lung cancer (NSCLC) cell line A549 and its underlying mechanisms. Methods: A549 cells were posed to X-rays in the presence or absence of allicin. The proliferation of A549 cells was detected by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Transwell assay was performed to detect the invasive ability of A549 cells. Clonogenic survival assay was used to evaluate cell radiosensitivity in A549 cells. DNA damage in A549 cells was assessed by comet assay. The protein level of γ-H2AX, Snail, Vimentin and lysine demethylase 5B (KDM5B) in A549 cells was measured by Western blot. qRT-PCR was utilized to measure the expression of miR-549-5p. The dual-luciferase reporter gene assay was employed to verify the targeting relationship of miR-486-5p with HDM5B. Results: Treatment with different concentrations of allicin (20, 40, 60 μg/mL) significantly inhibited the proliferation (P<0.05) and invasion ability (P<0.05) of A549 cells, as well as upregulated miR-486-5p expression in A549 cells (P<0.05). Treatment with 40 μg/mL allicin significantly upregulated the inhibitory effect of X-rays on the proliferation and invasion ability of A549 cells (all P<0.05) and accelerated DNA damage in A549 cells. Mechanistically, allicin enhanced the sensitivity of A549 cells to X-rays by upregulating miR-486-5p expression, but knockdown of miR-486-5p significantly reversed the radiosensitizing effect of allicin on A549 cells. Furthermore, miR-486-5p could negatively regulate its targeted KDM5B expression. Conclusion: Allicin could enhance the sensitivity of A549 cells to X-rays by inhibiting cell proliferation, invasion and inducing cellular DNA damage, and its mechanism of action is achieved by upregulating the inhibitory effect of miR-486-5p on KDM5B expression.
2022 Vol. 52 (5): 358-364 [Abstract] ( 442 ) HTML (1 KB)  PDF (1890 KB)  ( 623 )
365 AKAP9 promotes lung adenocarcinoma cell A549 proliferation and migration via enhancing the activity of  ERK pathway
FU Yangyang, HUANG Xiaoying, WANG Liangxing
DOI: 10.3969/j.issn.2095-9400.2022.05.004
Objective: To investigate the effect of A-kinase anchoring protein 9 (AKAP9) on lung cancer cell A549 and its possible molecular mechanism. Methods: Real-time quantitative polymerase chain reaction (RTqPCR) and Western blot were used to detect the knockdown effect of shRNA on lung cancer cell A549. 3-(4, 5-dimethylthiazole-2)-2, 5-diphenyltetrazolium bromide (MTT) and clone formation assay were performed to examine the role of AKAP9 in lung cancer cell proliferation. Transwell assay was performed to examine the function of AKAP9 in the migration of lung cancer cell A549. Flow cytometry was used to monitor cell cycle.Western blot was used to examine the expression of cell cycle associated proteins P27, Cyclin D1, cyclindependent kinase 4 (CDK4) and the phosphorylation level of epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK). Results: RT-qPCR and Western blot showed that shRNA could effectively silence the expression of AKAP9 in lung cancer cell A549. MTT and colony formation results showed that silencing AKAP9 significantly inhibited the proliferation and clonogenic ability of cancer cell A549 compared with the control group. Transwell assay showed that silencing AKAP9 suppressed the migration in lung cancer cell A549 compared with the control group. Flow cytometry results showed that silencing AKAP9 induced G1-S arrest in lung cancer cell A549 compared with the control group. Western blot results showed that silencing AKAP9 increased the expression of P27, decreased the expression of Cyclin D1, CDK4, and reduced the phosphorylation level of EGFR and ERK. Conclusion: Silencing AKAP9 may suppress proliferation and migration of lung cancer cell A549 by inhibiting the activity of ERK pathway.
2022 Vol. 52 (5): 365-370 [Abstract] ( 500 ) HTML (1 KB)  PDF (2181 KB)  ( 655 )
371 Therapeutic effect of respiratory muscle training on patients with obstructive sleep apnea syndrome
DAI Wei, SHU Danni, DAI Yuanrong, SHI Shengqiao, LIU Baohua
DOI: 10.3969/j.issn.2095-9400.2022.05.005
Objective: To study the therapeutic effect of respiratory muscle training on sleep apnea symptoms, sleep quality and lung function in patients with obstructive sleep apnea syndrome (OSAS). Methods:Forty OSAS patients treated in the Second Affiliated Hospital of Wenzhou Medical University from January 2019 to December 2020 were randomly divided into two groups. The control group was given routine treatment such as weight control and exercise, while the observation group was given guided respiratory muscle training on this basis. The data of body mass index (BMI), pulmonary ventilation function, Epworth Sleepiness Scale (ESS),Pittsburgh sleep quality index (PSQI), respiratory disorder index (AHI) and lowest oxygen saturation (LSaO2) of the patients in two groups were collected and analyzed. Results: There was no significant difference in general condition, pulmonary function and sleep quality between the two groups before treatment (P>0.05). After 6 weeks of treatment, compared with the control group, the observation group had significantly lower AHI, PSQI score and ESS score and the increased LSaO2 than before, with statistical difference (P<0.05). After 6 weeks,the tidal volume (VT), inspiratory capacity (IC), vital capacity (VC), maximum ventilation volume (MVV),maximum mid expiratory volume (MMEF), maximum inspiratory pressure (MIP), the maximum expiratory pressure (MEP) of the observation group were significantly higher than those in the control group (P<0.05). The improvement value of AHI before and after 6 weeks was correlated with that of MIP, MMEF, MEP, MVV and IC,showing statistical significance (P<0.05). Conclusion: Respiratory muscle rehabilitation training combined with general routine treatment can effectively improve daytime symptoms and pulmonary function of OSAS patients.
2022 Vol. 52 (5): 371-375 [Abstract] ( 449 ) HTML (1 KB)  PDF (1403 KB)  ( 616 )
376 Correlation between the language skill and parental alexithymia in 2-3 year-old children with language developmental delay
ZHOU Fan, SHENG Guanghui, ZOU Yang, PAN Hong, TANG Yechen, CHEN Li.
DOI: 10.3969/j.issn.2095-9400.2022.05.006
Objective: To explore the relationship between the language ability level and parental alexithymia in 2-3 years old children with language retardation. Methods: A total of 59 children with language delay aged 2-3 years who were admitted to the Second Affiliated Hospital of Wenzhou Medical University from January to June 2021 and their parents were selected as the subjects. The children’s development was evaluated by S-S test and Gesell Infant development scale.Parents were surveyed using the General information Questionnaire and the Toronto Alexithymia Scale. Results: Pearson correlation analysis found that parents’ alexithymia scores were significantly negatively correlated with scores of children's language developmental delay (motor subjects,symbol comprehension, language expression) (P<0.05). The results of regression analysis showed that the higher the parents’ alexithymia, the poorer ability of the children’s language developmental delay (symbol comprehension
ability, motor task ability). Conclusion: The more severe alexithymia of parents, the higher degree of children’s language delay.
2022 Vol. 52 (5): 376-381 [Abstract] ( 359 ) HTML (1 KB)  PDF (1447 KB)  ( 1032 )
382 Efficacy of metformin in the treatment of metabolic syndrome in patients with schizophrenia and its relationship with chronic inflammatory state
LI Meihua, ZHU Cheng, ZHENG Ke, LIU Jiahong, LYU Wei
DOI: 10.3969/j.issn.2095-9400.2022.05.007
Objective: To analyze the efficacy of metformin in the treatment of metabolic syndrome in patients with schizophrenia, and to further analyze the effect of the C-reactive protein (CRP) changes and tumor necrotic factor-α (TNF-α) on metabolic syndrome. Methods: According to the medical record number, 100 patients with schizophrenia who met the inclusion criteria and exclusion criteria were randomly divided into study group (n=50) and control group (n=50). Body mass index (BMI), homeostasis insulin evaluation index (HOMA-IR), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), CRP,TNF-α were measured before and 24 weeks after intervention treatment. Collected data were analyzed by SPSS.Results: There was no significant difference in sex, education, marriage, family history, course of disease, age and dose distribution of olanzapine between the study group and the control group (P>0.05). ΔBMI, ΔHOMA-IR,ΔFPG, ΔHbA1c, ΔHDL-C, ΔLDL-C, ΔTC, ΔTG, ΔCRP, ΔTNF-α in the study group was significantly higher than those in the control group after intervention (P<0.05). ΔCRP and ΔTNF-α in the study group had significantly positive correlation with ΔBMI and ΔHOMA-IR. ΔCRP could explain 13.4% of the ΔBMI variation and 11.4% of the ΔHOMA-IR variation, while 12.5% of the ΔBMI variation and 14.2% of the ΔHOMA-IR variation could be respectively explained by ΔTNF-α. Conclusion: Metformin can effectively improve the metabolic syndrome in patients with schizophrenia, while the improvement of metabolic syndrome may be related to the reduction of inflammatory state.
2022 Vol. 52 (5): 382-387 [Abstract] ( 418 ) HTML (1 KB)  PDF (1373 KB)  ( 539 )
388 Mutation analysis of 21 STR loci in Wenzhou population
LIN Lin, JIANG Huanchang, REN Ping, WU Shuzhen
DOI: 10.3969/j.issn.2095-9400.2022.05.008

Objective: To analyze the mutation situation and characteristics of 21 STR loci in Wenzhou population. Methods: A total of 21 200 samples from 9 418 paternity testing cases supporting parental relationship were collected and amplified with AGCU EX22 human fluorescent labeled STR multiplex amplification kit. The mutation rate of each locus and the source, fragment size, mutation steps and the increase or decrease of repeat units of mutant alleles were counted, and the correlation between mutation factors was analyzed. Results: In 9 418 paternity tests, 314 mutations cases and 319 mutation events were observed. Mutation was observed in 20 loci out of 21, with the mutation rate ranging between 0.08‰ and 3.48‰, and there was no significant difference in the mutation rate among each locus (χ2=29.77, P>0.05). The ratio of paternal mutation to maternal mutation was 4.78:1, and the mutation probability of paternal allele was generally greater than that of maternal allele, showing statistical difference (t=4.55, P<0.05). There was no significant difference in the increase,decrease and uncertainty of repeat units between paternal mutation and maternal mutation (χ2=0.28, P>0.05). There was significant difference in the increase, decrease and uncertainty of repeat units between one-step mutation and two-step or more mutations (χ2=7.22, P<0.05). There was statistical difference in the increase, decrease and uncertainty of repeat units in short, medium and long segment allele mutations (χ2=26.81, P<0.05). Conclusion:The allele mutation of STR locus is common, which should be paid attention to in the paternity test and the construction of DNA family search database.
2022 Vol. 52 (5): 388-393 [Abstract] ( 445 ) HTML (1 KB)  PDF (2134 KB)  ( 671 )
394 Efficacy of unilateral ilioinguinal transversus abdominis plane block for alleviation of catheter-related bladder discomfort in male patients after emergence from general anesthesia: a prospective, randomized controlled trial
ZHAO Xiyue, CHEN Lei, QIU Lili1, HU Yi, ZHUANG Guiquan, WANG Mengjia, WANGLiangrong
DOI: 10.3969/j.issn.2095-9400.2022.05.009
Objective: To investigate urinary catheterization frequently leading to catheter-related bladder discomfort (CRBD) in male patients after general anesthesia, and to prove the efficacy of unilateral ilioinguinal transversus abdominis plane block (TAPB) in attenuating CRBD in male patients. Methods: Male patients with a severe CRBD were randomized to receive unilateral ilioinguinal TAPB with 0.375% ropivacaine 10 mL (group T) or intravenous sufentanil 0.15 μg/kg (group C). The primary outcomes were the severity of CRBD at 0.5,1, 2, and 6 hours after treatment, and the other outcomes included the postoperative adverse events related to treatments. In addition, postoperative pain and need for analgesic drug were recorded. Tramadol was given to patients with moderate to severe CRBD. The findings were compared between the two Groups. Results: The incidence of moderate-to-severe CRBD in group T was significantly lower than in group C at 0.5, 1, 2, and 6 hours after treatment. The need for tramadol in Group T was significantly less than Group C (P<0.05). The postoperative incidences of sedation and respiratory depression were decreased significantly in group T, compared with group C (P<0.05). Conclusion: Unilateral ilioinguinal TAPB with ropivacaine could decrease the severity of CRBD and reduce the need for rescue agent. It could also reduce the incidence of agent-related complications in male patients after general anesthesia as compared with the therapy of intravenous sufentanil.
2022 Vol. 52 (5): 394-398 [Abstract] ( 400 ) HTML (1 KB)  PDF (1458 KB)  ( 587 )
399 Application of virtual laryngoscope construction in congenital pyriform sinus fistula
XIA Liguang, WANG Yongbiao, ZHU Libin, LIN Zhengxiu, LIN Jinhan, ZHAO Yiming, LI Zhongrong.
DOI: 10.3969/j.issn.2095-9400.2022.05.010
Objective: To introduce a method of constructing virtual laryngoscopy (VL) and its clinical application in the diagnosis and treatment of congenital pyriform sinus fistula (CPSF). Methods: CT data were obtained from children with CPSF. Three-dimensional reconstruction, surface rendering and image segmentation of laryngeal anatomical structure and upper respiratory tract were performed by using three-dimensional visualization software. Obtain computer-aided internal and external anatomical views and interactive penetrating continuous internal cavity views. Results: Three-dimensional laryngeal and upper respiratory tract anatomical structures of children with CPSF were successfully constructed. Obtain the comparison between the conventional view of the VL pyriform sinus and the traditional laryngoscope view. A unique view of the pyriform sinus that can be obtained in retrograde and antegrade visualization. Segmentation and transparency of the three-dimensional anatomical model can show the anatomical structure and orientation of CPSF as well as the spatial relationship with surrounding organs. The feedback from the use of virtual laryngoscope showed that: in the junior group,the rate conducive to diagnosis was 85.71%, and the rate of advantage for guiding intraoperative anatomy was 89.29%; while in the senior group, its conducive diagnosis rate was 57.89%, and the advantage rate for guiding intraoperative anatomy was 84.21%. Conclusion: VL has potential clinical application value as a non-invasive tool for evaluating CPSF and its scope. Combined with two-dimensional images, it can provide information
beyond traditional endoscopy for the diagnosis and treatment of CPSF. VL may have a greater reference value for junior doctors.
2022 Vol. 52 (5): 399-404 [Abstract] ( 599 ) HTML (1 KB)  PDF (2070 KB)  ( 599 )
405 Influence of self-concealment on college students’ attitudes toward professional psychological help-seeking:the chain mediating effect of help-seeking stigma and psychological distress
DU Meijie, GOU Shuangyu,WANG Lingli, YANG Yuli, ZHANG Wanzhu.
DOI: 10.3969/j.issn.2095-9400.2022.05.011
Objective: To explore the multiple mediating effects of professional psychological stigma and psychological distress on self-concealment and attitudes toward seeking professional psychological help. Methods: Totally 995 college students were selected and investigated using the self-concealment scale, the professional psychological help seeking stigma scale, the psychological distress scale and the attitude toward seeking professional psychological help-short form. Results: Correlation analysis showed that SCS and K10 were significantly correlated with the stigma of seeking psychological help scale scores (r=0.433, 0.479, 0.511,P<0.01). There was significant negative correlation between these three factors and the attitudes toward seeking professional psychological help (r=-0.356, -0.197, -0.197, P<0.01). A structural equation model was established with self-concealment as independent variable, with attitudes toward seeking professional psychological help as dependent variable, with psychological distress and psychological help-seeking stigma as mediating variable. All indexes fit well (χ2/df=3.984, GFl=0.994, AGFI=0.976, NFl=0.989, CFl=0.991, RMSEA=0.055). Conclusion:The stigma of seeking professional psychological help has a significant mediating effect between selfconcealment and attitudes toward seeking professional psychological help, and the stigma and psychological distress have a chain mediating effect between self-concealment and attitudes toward seeking professional psychological help.
2022 Vol. 52 (5): 405-409 [Abstract] ( 1338 ) HTML (1 KB)  PDF (1442 KB)  ( 1256 )
410 Influencing factors of problematic mobile phone use of college students
YE Sheng, XU Huihui, XU Zhuo,WANG Yirou, JIANG Yan, ZHANG Guohua
DOI: 10.3969/j.issn.2095-9400.2022.05.012

Objective: To explore the influencing factors of problematic phone use among college students in order to provide empirical evidence for mental health education and psychological intervention. Methods: A convenient sampling was used to conduct online questionnaire survey in November 2021 among 6543 college students from freshmen to seniors in China, who completed Mobile Phone Addiction Index, Basic Psychological Needs Satisfaction Scale of Self-Determination Theory, Brief Self-Control Scale, Sleep Time Procrastination Scale, Athens Insomnia Scale, Emotion Regulation Questionnaire, Depression Anxiety Stress Scale-21, Fear of Missing Out Scale. When the subjects answered yes to more than 8 items out of 17 in Mobile Phone Addiction Index, they were classified as problematic phone use. Binary logistic regression method was used to analyze the data. Results: Problematic smartphone use was increasing among undergraduates in China. Self-control in normal phone user group was significantly higher than that in problematic phone user group (P<0.001), and basic psychological needs, biorhythm, the sense of time value, the sense of time efficacy, sleep time procrastination, sleep quality, emotion regulation, stress, anxiety, depression and fear of missing out were significantly lower than that in problematic phone user group (P<0.05). The protective factor for problematic phone use was high level of self-control (OR=0.774, 95%CI: 0.756-0.793, P<0.001). In contrast, the risk factors were high level of sense of time value (OR=1.062, 95%CI: 1.045-1.079, P<0.001), sense of time effectiveness (OR=1.071, 95%CI: 1.050-
1.092, P<0.001), sleep time procrastination (OR=1.114, 95%CI: 1.098-1.129, P<0.001), emotion regulation (OR=1.027, 95%CI: 1.018-1.037, P<0.001), stress (OR=1.047, 95%CI: 1.010-1.086, P=0.012), and fear of missing out (OR=1.052, 95%CI: 1.042-1.063, P<0.001). Conclusion: Our findings will aid the early prevention
and treatment of problematic smartphone use among college students. Meanwhile, the correction of problematic smartphone use behavior and the influence of individual psychological factors need to be considered.
2022 Vol. 52 (5): 410-415 [Abstract] ( 1047 ) HTML (1 KB)  PDF (582 KB)  ( 881 )
419 Status quo and development strategies of intellectual property information service in medical universities from the perspective of patents
ZHU Bichun, LI Yunbo, CHEN Guijin, ZHAO Lihong.
DOI: 10.3969/j.issn.2095-9400.2022.05.014
Objective: To analyze the current situation of patents of medical universities and to investigate its intellectual property information services. Methods: Quality analysis was made of the patent application trend, authorization rate, conversion rate and patent life of 17 medical universities based on the PatSnap patent database, and the current situation of intellectual property information services carried out in recent years were also investigated. Results: Although different medical universities varied greatly in the awareness of intellectual property protection, the patent authorization rate of 12 medical universities was higher than the national average level. Since the patent information service in medical universities has just started, the patentees generally had weak awareness of patent transformation and maintenance due to the uneven development , low threshold of patent application, and incomplete service system. Compared with other medical universities, Capital Medical University and Nanjing Medical University had better patent performance resulting from earlier patent information services. Conclusion: To improve the quality and efficiency of intellectual property information services, medical universities should attach greater importance to the construction of intellectual property information service center, the extension of patent novelty search into each step of patent review, and further cooperation with patent agencies.
2022 Vol. 52 (5): 419-425 [Abstract] ( 353 ) HTML (1 KB)  PDF (1660 KB)  ( 627 )
426 Knowledge map analysis of SCI articles by Wenzhou Medical University from 2011 to 2020
GAO Chaofan, WU Qiang, ZENG Weizhong, SUN Fa.
DOI: 10.3969/j.issn.2095-9400.2022.05.015
Objective: To make a scientometrics analysis on SCI articles of Wenzhou Medical University published in recent ten years in order to give suggestions for its discipline construction. Methods: Papers of Wenzhou Medical University collected by Web of Science database from 2011 to 2020 were selected. Visual analysis tools such as Bibexcel, Pajek and bibliometric statistical methods were used to analyze the citations from the aspect of quantity, citation frequency, subject, journal of publication, author cooccurrence and research hot fields. Results: From 2011 to 2020, the number of SCI articles published by Wenzhou Medical University increased year by year and the citation frequency also showed an upward trend. Publications mainly concentrated on clinical medicine and pharmacy. Among the top 20 journals, the proportion of Q1 and Q2 journals of Chinese Academy of Sciences Division accounted for only about 15%. The most prominent cooperative teams were the ones respectively led by Li Xiaokun from School of Pharmacetuical Sciences and Qu Jia from School of Ophthalmology & Optometry. The most prominent cooperative institutions were Zhejiang University and University of Louisville. The literatures published by Livak KJ were the core of co-citation network. The institutional research hotspots were cancer treatment, disease diagnosis and drug research. Conclusion: Under the background of Double First-class Initiative, Wenzhou Medical University should attract more high-level talents and teams to promote the high quality publications by constantly strengthening the competitive disciplines and specialties and optimizing their layout, deepening the cooperation with top scientific research teams worldwide,modifying evaluation system and other measures.
2022 Vol. 52 (5): 426-430,封三 [Abstract] ( 372 ) HTML (1 KB)  PDF (1804 KB)  ( 994 )
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