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2022 Vol. 52, No. 2 Published: 2022-02-25   87 Extraction and identification of endometriosis-associated macrophages CHEN Sailing, WANG Fang, CHEN Huiqian, HU Xueli, WU Meiling, DUAN Ping DOI: 10.3969/j.issn.2095-9400.2022.02.001 Objective: To explore the method of extracting endometriosis (EMs)-associated macrophages (EAMs). Methods: Immunohistochemistry staining was used to explore the expression of CD68 and CD163 in pathological sections of ectopic endometrium (Ec) and normal endometrium (En). Collect three cases of EMs patients diagnosed by laparoscopy, separate EAMs by mechanical method combined with type IV collagenase digestion, and use flow cytometry to detect the expression of CD11b, CD163, and CD80. Results: High expression of type 2 macrophages can be seen in EMs tissues. The extracted EMs primary macrophages have the morphological characteristics of macrophages. The double-positive ratio of CD11b and CD163 is 6.46%, and no CD80-positive cell expression is seen. Conclusion: The method used in this study can effectively extract EAMs and improve their purity, which is of great value for further research on the characteristics and biological behavior of endometriosis-associated macrophages. 2022 Vol. 52 (2): 87-91 [Abstract] ( 784 ) HTML (1 KB)  PDF (1719 KB)  ( 1202 ) 92 The relationship between social support and psychological resilience in maintenance hemodialysis patients: the mediating effect of family resilience QIU Yuan, XU Liuqing, HE Chunlei, XU Huan, PAN Yinzhu, DONG Chaoqun DOI: 10.3969/j.issn.2095-9400.2022.02.002 Objective: To analyze the relationship between social support, family resilience and psychological resilience in maintenance hemodialysis patients and to explore the mediating effect value of family resilience in social support and psychological resilience. Methods: A total of 228 maintenance hemodialysis patients were selected from the First Affiliated Hospital of Wenzhou Medical University, the Second Affiliated Hospital of Wenzhou Medical University and Wenzhou People’s Hospital from September to December 2020. Maintenance hemodialysis patients were investigated with the Chinese version of the Medical Outcomes Study-Social Support Survey (MOS-SSS), Chinese Family Resilience Assessment Scale (C-FRAS), and Chinese version of the Conner and Davidson resilience scale (CD-RISC). The mediating effect analysis was conducted using structural equation modeling. Results: Social support and its dimension were positively correlated with family resilience (r=0.180-0.519, P<0.01) and psychological resilience (r=0.147-0.557, P<0.01) in maintenance hemodialysis patients; family resilience and its dimension were also positively correlated with psychological resilience (r=0.344-0.570, P<0.01). Family resilience played a partially mediating role between social support and psychological resilience in maintenance hemodialysis patients, with the mediating effect accounting for 32.9% of the total effect value. Conclusion: Social support in maintenance hemodialysis patients not only affects individual psychological resilience, but also indirectly exerts its effect through family resilience. In clinical practice the important role of social support and the effect of family resilience on psychological resilience should be fully considered. Social support interventions and family resilience interventions should be integrated to improve their psychological resilience. 2022 Vol. 52 (2): 92-97 [Abstract] ( 858 ) HTML (1 KB)  PDF (1567 KB)  ( 875 ) 98 Video-assisted thoracoscopic redo mitral valve replacement under hypothermic fibrillatory arrest in patients with previous sternotomy WANG Shuwei, CUI Yong, ZHOU Bing, MEI Fuyang, LIU Zhifang, HU Zhibin DOI: 10.3969/j.issn.2095-9400.2022.02.003 Objective: To summarize the experience in minimally invasive redoing mitral valve replacement with hypothermic fibrillatory arrest technique in patients with a previous cardiac procedure performed through a sternotomy. Methods: The clinical data of 35 patients who underwent video-assisted thoracoscopic mitral valve replacement after previous cardiac surgery (PCS) from October 2017 to December 2019 in Zhejiang Provincial People’s Hospital were retrospectively analyzed. 78 patients who underwent video-assisted thoracoscopic mitral valve replacement (first cardiac surgery, FCS) at the same time were assigned to the control group. All the 113 patients were followed up for 6 months, and their perioperative data and follow-up results were compared between the two groups. Results: There was no significant difference between the two groups in terms of gender, age, tricuspid valve disease, atrial fibrillation, and other major preoperative clinical indicators. The operation time and cardiopulmonary bypass time were longer in the PCS group compared with FCS group [(226.5±11.4) min vs. (189.6±17.7)min, (148.1±16.3)min vs. (105.3±15.3)min, both P<0.01]. There was no significant difference between the two groups in 24-hour post-operative drain volume and perioperative blood transfusion rate [(205.8±27.8)mL vs. (195.3±26.3)mL, 17.1%(6/35) vs. 21.8%(17/78), both P>0.05]. There was no significant difference in postoperative peak cardiac troponin I and blood lactate [(3.0±1.1)μg/L vs. (2.5±1.3)μg/L, (3.0±0.9)mmol/L vs. (2.7±0.8)mmol/L, both P>0.05]. No serious neurological or respiratory complications occurred in all patients postoperatively. At 6-month postoperative follow-up, there was no cardiac death or rehospitalizations for heart failure in either group, and there was no significant difference in cardiac function classification or left ventricular ejection fraction between the two groups (both P>0.05). Conclusion: It is safe and feasible to redo mitral valve replacement using video-assisted thoracoscopy with hypothermic fibrillatory arrest technique in patients with a previous cardiac procedure. In addition to providing good intraoperative exposure, the technique can significantly simplify the operation and obtain satisfactory short-term follow-up results. 2022 Vol. 52 (2): 98-103 [Abstract] ( 512 ) HTML (1 KB)  PDF (1410 KB)  ( 966 ) 104 Expression of hsa_circ_0001322 in gastric cancer and it’s clinical significance WU Wenyi, BAI Yongyu, Zhuang Xiaopeng, CAI Yiqi, ZHOU Zhuha, Ruan Xiaojiao DOI: 10.3969/j.issn.2095-9400.2022.02.004 Objective: To analyze the expression change and diagnostic value of a circular RNA, hsa_circ_0001322 in gastric cancer. Methods: Gastric cancer mucosa tissues and paired normal gastric mucosa tissues of 54 patients were collected in the First Affiliated Hospital of Wenzhou Medical University from October 2019 to April 2020. The expression level of hsa_circ_0001322 was examined using real-time quantitative polymerase chain reaction (RT-qPCR) and its correlation with different clinicopathological factor groups were analyzed. Results: The expression level of hsa_circ_0001322 in gastric cancer tissues was lower than that in normal gastric mucosa tissues (0.309 vs. 1.000, P<0.05). The lower expression of hsa_circ_0001322 was also significantly associated with lymph node (LN) metastasis (0.208 vs. 0.391, P<0.05). Partial correlation analysis showed that the expression level of hsa_circ_0001322 was negatively correlated with LN metastasis of gastric cancer (R=-0.587, P<0.05), after excluding the influence of age, gender, tumor size, tumor location, depth of invasion or cell differentiation. The area under the ROC curve of hsa_circ_0001322 was 0.808, and the sensitivity and specificity of prediction with threshold value at 0.254 was 90.0% and 75%, respectively. Conclusion: Down-regulation of hsa_circ_0001322 was correlated with gastric cancer tissue and lower expression of hsa_circ_0001322 was evidently associated with lymph node metastasis, which suggested that hsa_circ_0001322 may serve as a potential biomarker for diagnosis of gastric cancer and prediction of lymph node metastasis. 2022 Vol. 52 (2): 104-108 [Abstract] ( 551 ) HTML (1 KB)  PDF (1443 KB)  ( 910 ) 109 Construction of predictive model for recurrent respiratory tract infections based on children’s nutrition-related indicators and its validation analysis HU Guanqiong, JIA Xiumei, HUANG Junlin DOI: 10.3969/j.issn.2095-9400.2022.02.005 Objective: To construct and validate a predictive model for recurrent respiratory tract infection based on nutrition-related indicators in children. Method: Altogether 283 children with respiratory infections admitted to the First Affiliated Hospital of Wenzhou Medical University from January 2018 to March 2020 were selected as the research subjects, and all received standardized treatment. They were divided into the recurrent respiratory infection group and the non-recurrent respiratory infection group according to whether the respiratory tract infection recurred or not, with 198 cases (70%) and 85 cases (30%) randomly selected as training set and test set respectively. Their clinical data were compared, and the logistic regression model was used to analyze the related factors of recurrent respiratory infection. And a nomogram prediction model was built on the training set, using decision curve analysis to evaluate the clinical net benefits of the Nomogram model, and the effectiveness of the model was evaluated on the test set. Results: The ratio of family history of chronic respiratory diseases, birth weight, outdoor activity time, breastfeeding time, hemoglobin, vitamin A, vitamin D levels were statistically different (P<0.05). There was no significant difference in gender, age, body mass index, place of residence, birth method, asphyxia, sleep time, white blood cell count, serum zinc, iron, calcium, and magnesium (P>0.05). Multivariate logistic analysis showed that high birth weight (OR=0.995, P=0.004), long time outdoor activity (OR=0.630, P=0.003), increased hemoglobin level (OR=0.846, P<0.001), increased vitamin A level (OR=0.437, P<0.001), increased vitamin D level (OR=0.938, P=0.007) were protective factors for children with repeated respiratory infections. The C-index of the Nomogram model constructed to predict recurrent respiratory tract infection was 0.869 (95%CI=0.818-0.920). Decision curve analysis made to evaluate the clinical benefits of the two prediction models showed that additional clinical benefits could be provided when the value of nutrition-related indicators to predict children with recurrent respiratory tract infection fell within the range 0-0.59. External verification showed that the sensitivity was 92.00% and the specificity 96.67%, with the accuracy rate being 95.29%. Conclusion: Higher birth weight, prolonged outdoor activities, elevated levels of hemoglobin, vitamin A and vitamin D were protective factors for children with recurrent respiratory infections. The Nomogram model constructed with vitamin A and vitamin D nutritional indicators can improve the predicting accuracy for recurrent respiratory tract infections in children. 2022 Vol. 52 (2): 109-114，120 [Abstract] ( 545 ) HTML (1 KB)  PDF (1490 KB)  ( 693 ) 115 Curcumin regulates LncRNA MEG3/miR-21/PTEN pathway to promote the apoptosis of HPV-positive cervical cancer cells HUANG Ying, SHI Yaoqi, HU Jiaming, NI Xinyu, ZHU Hua DOI: 10.3969/j.issn.2095-9400.2022.02.006 Objective: To explore the mechanism of curcumin in killing HPV-positive cervical cancer cells. Methods: First, the effect of curcumin on the viability and apoptosis of HPV-positive cervical cancer cells were analyzed by cell viability detection experiment and apoptosis detection experiment; then, real-time quantitative PCR experiment and Western blot were used to analyze the changes in key signal pathways of curcumin in the process of promoting the apoptosis of HPV-positive cervical cancer cells. Results: Curcumin significantly promoted the apoptosis of HPV-positive cervical cancer cells, increased the expression levels of LncRNA MEG3, PTEN and activated caspase3, and down-regulated the expression of miR-21; and knocking down the expression of LncRNA MEG3 by siRNA ccould reverse the regulation of curcumin on miR-21, PTEN and caspase3. Conclusion: Curcumin may decrease the expression of miR-21 by up-regulating LncRNA MEG3, thereby up-regulating the expression of PTEN, and ultimately promote the apoptosis of HPV-positive cervical cancer cells. 2022 Vol. 52 (2): 115-120 [Abstract] ( 734 ) HTML (1 KB)  PDF (2479 KB)  ( 692 ) 121 The predictive value of morphological and radiomics-derived features in the rupture of middle cerebral artery mirror aneurysms WANG Hao, ZHOU Jiafeng, LIN Boli, CHEN Yongchun DOI: 10.3969/j.issn.2095-9400.2022.02.007 bjective: To investigate the predicting value of morphological and radiomics-derived feature logistic model in the rupture of middle cerebral artery mirror aneurysm. Methods: Totally 38 patients with middle cerebral artery mirror aneurysms (one side ruptured and one side unruptured) in the First Affiliated Hospital of Wenzhou Medical University from May 2010 to October 2020 were retrospectively analyzed. In the pairing of ruptured and unruptured mirror aneurysms, 7 morphological parameters were measured using CTA, and 12 radiomics-derived morphological parameters were extracted using Pyradiomics. Univariate analysis was used to select the related factors of aneurysm rupture. Logistic regression model for predicting the rupture of the middle cerebral artery mirror aneurysms was established based on morphological features, radiomics-derived features and morphological features combined with radiomics-derived features. Receiver operating characteristic curve and area under curve were used to evaluate the predictive performance of the model. Results: After univariate analysis, 7 morphological parameters (including aneurysm size, perpendicular height, aneurysm height, aneurysm neck size, aspect radio, size radio and aneurysm shape) and 6 radiomics-derived parameters (including Maximum3DDiameter, Maxium2DDiameterSlice, Maximum2DDiameterColumn, Maximun2DDiameterRow, SurfaceArea and SurfaceVolumeRatio) were selected. The results of the ROC curve were as follows: The AUC of combined model was 0.85, which was higher than that of morphological model (AUC=0.83) and radiomics model (AUC=0.71).Conclusion: Logistic regression model based on morphological and radiomics-derived features may be helpful in assessing the risks of middle cerebral artery aneurysm rupture independent of individual patient’s characteristics. 2022 Vol. 52 (2): 121-125 [Abstract] ( 583 ) HTML (1 KB)  PDF (1435 KB)  ( 879 ) 126 Risk factors for emergency room patients with catheter-associated urinary tract infections and the establishment of prediction model LYU Yangyang, HUANG Haiqun, LIANG Chengying, JIN Qianqian DOI: 10.3969/j.issn.2095-9400.2022.02.008 Objective: To explore the risk factors for patients with catheter-associated urinary tract infection (CAUTI) in the emergency room and to establish a risk prediction model. Methods: A total of 1 780 patients with indwelling catheter in the emergency room of our unit from June 2018 to December 2020 were retrospectively analyzed by single factor and multivariate Logistic regression analysis to find out the independent risk factors for CAUTI. Based on the results, a risk prediction model was established, the fitting degree of the model tested by Hosmer-Lemeshow and predictive value of the regression model evaluated by the receiver operating characteristic (ROC) curve. Results: The incidence of CAUTI was 7.98% during the period of this study. Compared with reference, Age≥60 years old, BMI≥30 kg/m2, indwelling time of catheter≥3 d and HbA1c were independent risk factors for CAUTI in emergency room patients, while serum Albumin level was protective factor for CAUTI (OR=1.637, 3.052, 3.135, 1.563, 0.896, respectively, all P<0.05). According to the results, the risk prediction model was constructed and the fitting degree was acceptable (χ2=13.383, P=0.099). ROC analysis showed that the area under curve (AUC) of the regression model was 0.870, with the corresponding sensitivity being 83.10% and specificity 78.45%. In addition, ROC analysis was made for HbA1c,serum albumin and the two combined detection, with the corresponding AUC being 0.759, 0.618 and 0.842, respectively, and sensitivity being 52.82%, 35.92%, 67.61% and specificity 90.54%, 90.72%, 90.90% accordingly. Conclusion: CAUTI in emergency room remains a major source of nosocomial infection. The regression model constructed in this study has good predictive effect, and the combined detection for HbA1c and serum albumin could be of better predictive value than any single index. In clinical practice, it is necessary to take comprehensive nursing preventive measures according to the above-mentioned factors. 2022 Vol. 52 (2): 126-131，138 [Abstract] ( 591 ) HTML (1 KB)  PDF (1460 KB)  ( 885 ) 132 Application of rapid on-site evaluation combined with radial-endobronchial ultrasound of transbronchial cryobiopsy in the diagnosis of diffuse lung diseases CHEN Weizhuang, LI You, WANG Hui, ZHOU Yingyan, WANG Guoan, Shen Shimo, Chen Jinping, WU Shibo, WU Hongcheng DOI: 10.3969/j.issn.2095-9400.2022.02.009 Objective: To investigate the feasibility and safety of transbronchial cryobiopsy (TBCB) in the diagnosis of diffuse lung diseases (DLD) with assistance of Rapid On-Site Evaluation (ROSE) and Radial-endobronchial ultrasound (R-EBUS). Methods: Patients with diffuse lung disease who underwent TBCB from June 2019 to September 2021 were enrolled and their clinical characteristics, pathological types, biopsy characteristics and complications were recorded. Results: A total of 52 patients were included in the study, 20 males and 32 females, with a mean age of (54.0±13.2) years; a total of 182 cryobiopsies, (3.50±1.00) cryobiopsies per patient; the mean size of tissues was (13.69±4.72) mm2, ranging 6-30 mm2. According to the 2013 ATS/ERS classification standard for the interstitial lung diseases, there were 26 cases of known etiology (50.00%), 13 cases of idiopathic interstitial pneumonia (25.00%), 4 case of granulomatous lesions (7.69%) and 9 cases of other types (17.31%). In terms of complications, none or minimal bleeding occurred in 20 patients, mild bleeding in 21 patients, moderate bleeding in 11 patients. No severe bleeding occurred. Pneumothorax occurred in 2 patients, acute left heart failure in 1 patient and hypoxemia in 1 patient. The median post-TBCB hospital day was 6 (1.00, 6.00) days. Conclusion: The combined application of ROSE and R-EBUS in TBCB is feasible and safe in the diagnosis of DLD. 2022 Vol. 52 (2): 132-138 [Abstract] ( 511 ) HTML (1 KB)  PDF (2274 KB)  ( 809 ) 139 The predictive value of transcranial magnetic stimulation combined with clinical assessment in motor recovery of hemiplegic upper limbs PAN Lulu, ZHENG Hebin, ZHANG Yanyan, CHENG Zhiqing, PAN Rongrong, ZHANG Guowei, ZHI Yinghao DOI: 10.3969/j.issn.2095-9400.2022.02.010 Objective: To investigate the predictive value of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (EDC-MEPs) of extensor muscles combined with clinical evaluation (SAFE) in the recovery of upper limb motor function 3 months after cerebral infarction. Methods: Totally 76 patients with cerebral infarction hospitalized in the Rehabilitation Department of Wenzhou Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were enrolled in this study. All patients received Fugl-Meyer upper limb motor function assessment, SAFE assessment and TMS assessment upon admission, and again 3 months after cerebral infarction. Three prediction methods (SAFE, EDC-MEPs and SAFE combined with EDC-MEPs) were established according to the assessment content. Multi-factor logistic regression analysis was used to determine the predictors of upper limb functional recovery, and the efficacy of prediction methods was evaluated by ROC curves. Results: Multi-factorial analysis showed statistical difference among SAFE, EDC-MEPs and SAFE combined with EDC-MEPsin the effect on functional recovery of the upper limb (P<0.05). The area under the ROC curve (AUC) for SAFE was 0.795 (SE=0.059, 95%CI=0.680-0.910) and for EDC-MEPs it was 0.729 (SE=0.067, 95%CI=0.599-0.860), but SAFE combined with EDC-MEPs it was increased to 0.824 (SE=0.056, 95%CI=0.715-0.934), showing significant difference compared with EDC-MEPs (Z=2.398, P<0.05). Conclusion: Transcranial magnetic stimulation combined with clinical assessment is of higher value in predicting functional recovery of hemiplegic upper limbs after cerebral infarction. 2022 Vol. 52 (2): 139-143 [Abstract] ( 463 ) HTML (1 KB)  PDF (1424 KB)  ( 841 ) 144 The correlation between lymphocytes and hemorrhagic transformation and prognosis after thrombolysis ZHOU Chaofan, GE Wanqian, WEI Limin, ZHOU Chengye DOI: 10.3969/j.issn.2095-9400.2022.02.011 Objective: To explore the correlation between lymphocytes and hemorrhagic transformation after thrombolysis and the prognosis of different stages. Methods: A total of 457 patients included in the First Affiliated Hospital of Wenzhou Medical University from January 2016 to December 2018 were treated with intravenous thrombolysis, and 324 patients were finally enrolled. Enrolled patients can be divided into hemorrhage transformation group and non-hemorrhage transformation group according to the CT imaging, good prognosis group and poor prognosis group according to the modified Rankin Scale (mRS). Baseline data of patients including lymphocyte count before thrombolysis were collected. The assessment of neurological dysfunction was performed using the National Institutes of Health Stroke Scale (NIHSS). The mRS was used to assess the clinical prognosis after 3 months and 12 months, respectively. Results: There was no significant difference in lymphocytes in the hemorrhagic transformation group (P>0.05). Lymphocytes [OR=0.640, 95%CI=(0.420, 0.975), P=0.038], NIHSS (OR=1.330, 95%CI=1.232-1.435, P<0.001), and diabetes (OR=2.203, 95%CI=1.199-4.047, P=0.011) were relevant factors in the 3-month prognosis. Lymphocytes count [OR=0.555, 95%CI=0.347-0.888, P=0.014], age (OR=1.045, 95%CI=1.015-1.075, P=0.003), NIHSS (OR=1.297, 95%CI=1.202-1.398, P<0.001), and diabetes (OR=2.769, 95%CI=1.455-5.272, P=0.002) were relevant factors in the 12-month prognosis study. Conclusion: Lymphocytes have no significant correlation with hemorrhagic transformation after thrombolysis. But High lymphocyte count is the protective factors for poor prognosis in patients with acute ischemic stroke after thrombolytic therapy both in the 3-month and 12-month. 2022 Vol. 52 (2): 144-148 [Abstract] ( 459 ) HTML (1 KB)  PDF (1379 KB)  ( 810 ) 149 The removal effect of chlorine dioxide on the biofilm of the waterway system of dental comprehensive treatment chair CHEN Xiaofen, JI Yinghui, HUANG Kui DOI: 10.3969/j.issn.2095-9400.2022.02.012 Objective: To explore the control effect of chlorine dioxide (ClO2) on the biofilm in the waterway system of the dental unit. Methods: Select 30 dental comprehensive treatment chairs in Hospital of Stomatology Wenzhou Medical University from July 2019 to December 2019, and apply 5 mg/L chlorine dioxide disinfectant to the dental unit waterline (DUWL) disinfection, and compare disinfection DUWL average colony count, bacterial biofilm coverage and distribution changes on the pipe wall in each time period after disinfection. Results: The average colony count of DUWL in each time period after disinfection with low concentration of ClO2 was significantly lower than before disinfection, showing statistical difference (P<0.05); after disinfection, the bacterial biofilm coverage area on the distal, middle and proximal pipe walls was decreased, and the damaged fence-like structure and dot-like distribution could be seen. Conclusion: ClO2 chlorine dioxide can effectively remove the biofilm in the waterway system of the dental comprehensive treatment chair, thus producing an excellent bactericidal effect by inhibition of flora growth. 2022 Vol. 52 (2): 149-152 [Abstract] ( 445 ) HTML (1 KB)  PDF (2461 KB)  ( 845 ) 153 Three different sites of phosphaturic mesenchymal tumor: a clinicopathologic analysis SONG Chunhong, WU Liang, YIN Weiwei, WANG Rongrong DOI: 10.3969/j.issn.2095-9400.2022.02.013 Objective: To study the clinicopathological features of the phosphaturic mesenchymal tumors (PMT). Methods: Clinical data, histopathological and immunohistochemical features of 3 PMT cases at different cites from the First Affiliated Hospital of Wenzhou Medical University were analyzed retrospectively. Results: Blood phosphorus decreased significantly in 3 cases before operation, 1 case was accompanied by adult chondropathy and 3 cases returned to normal after operation. The tumor cells were spindle shaped, oval, arranged in bundle or braid, without obvious atypia ornuclear division. Abundant blood vessels, and smoke-like matrix could be found in the stroma. In some cases, mucoid, bone-like matrix and mature adipose tissues could be seen. The tumor cells expressed Bcl-2, CD56, CD99 and Satb2. Conclusion: Phosphaturia mesenchymal tumor is quite rare and its diagnosis should be based on histopathology, immunohistochemical markers and clinical data. 2022 Vol. 52 (2): 153-157 [Abstract] ( 493 ) HTML (1 KB)  PDF (1889 KB)  ( 846 ) 163 Exploration and implementation of network education of colleges and universities in the new era: take Wenzhou Medical University as an example LIU Xiaoli, LI Junhong DOI: 10.3969/j.issn.2095-9400.2022.02.016 Network education is a strategic move of moral education, is the due righteousness of “three all-around education”, and is the important path of ideological and political education innovation. In view of the current difficulties of network education in colleges and universities, such as lack of attractive contents, uneven platform construction, insufficient  overall cooperation, inadequate response to public opinion, and imperfect education mechanism, Wenzhou Medical  University has explored and constructed a “five-force coordinated” mode to promote the integration of contents supply, platform communication, team coordination, public opinion guidance and mechanism regeneration to enhance the network education effect, which will be referential to the exploration of network education of colleges and universities across the country. 2022 Vol. 52 (2): 163-166 [Abstract] ( 475 ) HTML (1 KB)  PDF (1344 KB)  ( 782 ) 167 An exploration on the cultivation of college students’ critical thinking ability based on peer scaffolding WANG Yansu DOI: 10.3969/j.issn.2095-9400.2022.02.017 Objective: To explores the influence of peer scaffolding on the cultivation of college students’ critical thinking ability (CTA) and its specific performance based on the student-centered group collaborative English teaching and learning. Methods: A total of 120 students were selected from two natural classes in the department of Clinical Medicine, Wenzhou Medical University, with College English blended teaching adopted and practiced on a 16-week basis. The collected data were qualitatively analyzed using NVivo tools. Results: Group collaboration under the role of peer scaffolding was helpful for the cultivation of CTA; the scaffolding support of language, content and emotion given by peers during group collaboration had a certain impact on students’ meta-critical ability, critical cognition, and critical emotion. Conclusion: Designing effective group collaboration tasks, paying attention to students’ thinking and emotional quality, and creating a good group collaboration social environment are helpful to form a learning community atmosphere, thereby promoting the cultivation of CTA among group members. 2022 Vol. 52 (2): 167-172 [Abstract] ( 460 ) HTML (1 KB)  PDF (1414 KB)  ( 799 )

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