温州医科大学学报
 
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2017 Vol. 47, No. 10
Published: 2017-10-25

 
 
703 Observation on the process of vascular reconstruction in acellular hepatic scaffolds of rat after transplantation into the greater omentum
HUANG Junjie, WANG Zhibin, CHEN Na, ZHANG Jianse, WANG Zhiyi, LI Ting, Dai Kaiyu, MEI Jin, LOU Xinfa.
Objective: To observe the process of vascular reconstruction in acellular hepatic scaffolds of rat after transplantation into the greater omentum. Methods: Acellular hepatic scaffolds were harvested from adult SD rats by perfusing with TritonX-100. The scaffolds and native livers were observed through genomic DNA content analysis, scanning electron microscopy, HE stain, immunofluorescence and vascular cast. Then the acellular hepatic scaffolds were transplanted into the greater omentum in rats to investigate the vascular reconstruction. Rats were sacrificed respectively at 1, 3, 7, 14 or 28 days post-implantation and sections from the explanted grafts were analyzed by HE stain for morphology and microstructures. Results: Scanning electron microscope, HE stain and immunofluorescence showed most collagen fibers but no visible cell nuclei remained after decellularization in the scaffolds compared with the native livers. Vascular cast showed the pipeline structures of acellular hepatic scaffolds were intact and clear. Quantitative analysis of DNA content within the scaffolds showed only (211.6 ± 25.3) ng/µL. Then the blood sinus were observed on border of grafts at 3 days after transplantation into greater omentum. Afterwards the neovessels appeared, got into the internal of scaffolds, and formed microvascular network gradually in hepatic scaffolds after 14 days. The de novo microvascular network were still existed in hepatic scaffolds on 28 days. Conclusion: The implantation of greater omentum can promote the recellularization and eventually formation of vascularized reticular structures in the decellularized hepatic scaffolds.
2017 Vol. 47 (10): 703-707 [Abstract] ( 732 ) HTML (1 KB)  PDF (1640 KB)  ( 1083 )
708 Comparison of the expression of piRNA in gastric carcinoma and normal gastric mucosa tissues
JIANG Peipei, CAI Yiqi, WANG Pengfei, CHEN Xiaodong, JIN Jinji, HU Changyuan, CHEN Wenjing, XUE Xiangyang, ZHANG Lifang, ZHU Guanbao
Objective: To analyze the differences of expression of piRNA in gastric carcinoma and normal gastric mucosa. Methods: The small RNA (sRNA) deep sequencing of gastric cancer tissue and normal gastric mucosa was performed by a new generation of high throughput sequencing technology, and the differential expression of piRNA was detected in gastric cancer tissue and normal gastric mucosa by follow-up bioinformatics. Four kinds of piRNAs (login ID: DQ570956, DQ575659, DQ594126 and DQ597128) were selected according to the results of the analysis, and their presence and their differences in gastric cancer tissues and normal gastric mucosa were verified by real-time quantitative PCR. Results: Solexa depth sequencing results showed that there was no significant difference in the proportion of sRNA measured in normal gastric mucosa and gastric cancer tissues (Z=0.835, P=0.678). The number of piRNAs measured in normal tissues was significantly higher than that in gastric cancer tissues (Z=2.167, P=0.042). Four piRNAs were selected according to the analysis results. The expression of that 4 piRNA in gastric cancer tissues was significantly lower in normal gastric mucosa (P<0.05). Conclusion: There are many differentially expressed piRNAs in gastric cancer tissues, and there is significant difference in the normal gastric mucosa. In this study, four piRNAs may be involved in the development and progression of gastric cancer, and the subsequent development of piRNA and gastric cancer of the pathogenesis of the study to provide experimental basis.
2017 Vol. 47 (10): 708-712 [Abstract] ( 601 ) HTML (1 KB)  PDF (1305 KB)  ( 902 )
713 Effects of propofol on potassium channels of S1 neurons in rats
HE Jiongce, ZHANG Yu, LIU Xingkui, YU Tian, HUANG Qianyu
Objective: To explore the effects of propofol on voltage-gated potassium channels of primary S1 neurons in rats. Methods: Whole-cell patch clamp technique was used to record potassium currents of neurons. After application with propofol at different concentrations (10-300 μmol/L) in ACSF, the currents of outward potassium currents (IA) and delayed rectifier potassium currents (IK) were recorded to make current-voltage curve, steady-state activation curve and account characteristic parameters. Results: Propofol inhibited IA of S1 neurons in rats in a dose-dependent manner. It also inhibited the activation of IA, shifted the activation curve towards the deperpolarzating potential. Propofol inhibited IK of S1 neurons of rats in a dose-dependent manner. But it did not affect activation of IK. Conclusion: The results of this study provide new vidence that propofol shows an inhibitory effect on voltage-gated potassium channels in the thalamocortical circuit, which may play a role in the mechanisms of propofol-induced general anesthesia.
2017 Vol. 47 (10): 713-717 [Abstract] ( 645 ) HTML (1 KB)  PDF (1591 KB)  ( 880 )
718 The influence of regulatory T cells on dendritic cells in mice with hepatocellular carcinoma
DU Yong, HUANG Zhiming, LIN Xiuqing, CHEN Xin.
Objective: To investigate how CD4+CD25+ regulatory T cells (Tregs)impacted on dendritic cells which were separated from BALB/c mice with hepatocellular carcinoma. Methods: BALB/c mice with hepatocellular carcinoma were established in laboratory. Twenty-five days after the models, the tumor-bearing mice were sacrificed and fresh spleen tissues were separated. Tregs, CD4+CD25-T cells and dendritic cells were separated from the mice’s spleen and purified by immuno-magnetic beads according to the manufacturers’ instructions. Tregs were co-cultured with CD4+CD25-T cells and the proliferation experiment was measured with CCK8. Tregs were directly co-cultured with dendritic cells and then the expression of CD80/CD86 on dendritic cells was detected by flow cytometry. The levels of TNF-α and IL-12 in supernatants were detected by ELISA. Results: We successfully established the tumor model of hepatocellular carcinoma and obtained high purity of Tregs, CD4+CD25-T cells and dendritic cells. Tregs could suppress the proliferation of CD4+CD25-T cells in vitro. Tregs could down-regulate the expression of CD80/CD86 on dendritic cells and inhibit the expression of TNF-α and IL-12. Conclusion: Tregs play an important role in the establishment and persistence of tumor immune suppression. Tregs can inhibit the function of dendritic cells in tumor-bearing mice. So Tregs may be a promising therapeutic target for cancer.
2017 Vol. 47 (10): 718-722 [Abstract] ( 721 ) HTML (1 KB)  PDF (1532 KB)  ( 801 )
723 The healing function of basic fibroblast growth factor on the wound of second degree burns in rats
LIN Beibei, YU Yinfei.
Objective: To examine the effect of topical basic fibroblast growth factor (bFGF) on wound healing in a rat skin partial thickness burn wound model. Methods: Female Sprague-Dawley rats were anaesthetized with an intraperitoneal injection of 10% chloralic hydrate (3.5 mL/kg). Hairs on the rat dorsum were clipped and then two partial thickness burn skin flaps were cut per rat. The two wounds were separated by at least 1.5 cm of unwounded skin. The right-side wounds were treated with different doses of bFGF, while the left-side wounds received equal volumes of saline as controls. Wounded rats were randomly divided into three groups (fifteen rats per group) and they were treated with 125, 500 and 2 000 ng of bFGF in right wounds respectively. bFGF treatments were repeated under anesthesia every other day for 14 days. The tissues were harvested and detected with Masson stain and immunohistochemistry to observe the expression of CD68, MMP-2, PCNA and TGF-β1. Results: By quantitative assessment of wound healing, we found that bFGF treatment significantly accelerated the rate of burn wound healing. Masson staining show that bFGF promoted the formation of granulation tissue and collagen production of wound. Immunohistochemical staining showed that the levels of CD68, MMP-2, PCNA and TGF-β1 were significantly regulat in bFGF-treated groups compared to control. Conclusion: These findings suggest that bFGF significantly accelerates the healing of partial thickness burn wound healing by regulating the expression of CD68, MMP-2, PCNA and TGF-β1 in rats
2017 Vol. 47 (10): 723-729 [Abstract] ( 674 ) HTML (1 KB)  PDF (1818 KB)  ( 852 )
730 Development and psychometric testing of self-management scale for nurses who operate a sharp instrument
WANG Tingting, HUANG Fangfang, LIAO Xiaojuan, YIN Zhiqin, XUE Liming
Objective: To compile an self-management scale for nurses who operate medical sharps. Methods: A provisional version of the scale was formed by reviewing the relevant literature, semi-structured interviews and Delphi expert consultation. A questionnaire was used to investigate 194 standard nurses, and then analyze the dates and examine reliability and validity. Results: The self-management scale for nurses who operate medical sharps deleted three items by analysis. The criteria value of the remaining items was 3.790-18.154. The correlation coefficient of each item score and total scores was 0.425-0.797. Factor analysis showed that the accumulated contribution rate of the five factors was 66.773%, the correlation coefficient of each factor and total factors is 0.494-0.908. The content validity was 0.956; the Cronbach’s α coefficient was 0.902; the split-half reliability was 0.756; the test-retest reliability was 0.922. Conclusion: The self-management scale has a good reliability and a good validity. It not only can be used to assess the level of self-management of medical sharps in nurses, but also provide an evaluation tool for related intervention.
2017 Vol. 47 (10): 730-734,738 [Abstract] ( 708 ) HTML (1 KB)  PDF (2431 KB)  ( 1019 )
735 Curcumin inhibits the proliferation of human renal cell carcinoma 786-O in nude mice via Erk1/2 signaling pathway
ZHAO Jiantong, ZHANG Lei, LIU Wenzhan, XU Fei, GUO Mingtao, LU Zhimin, XIAO Bo.
Objective: To investigate the inhibitory effect of curcumin on 786-O cells and explore the potential mechanisms. Methods: Nude mice were randomly divided into two groups. Human kidney cancer cells 786-O were inoculated in nude mice. Intervention group mice were treated with curcumin and the control group mice were treated with PBS. The inhibition rate of tumor in the intervention group was determined. p-Erk1/2 and p-Akt expression was detected using Western blot and immunohistochemistry. Results: The average weight of the tumor of nude mice was (1.03±0.17)g in the intervention group and (2.46±0.48)g in the control group, the difference was significant (P=0.02). The tumor inhibition rate of mice treated with curcumin was 58.13%. Western blot and immunohistochemical staining showed that the phosphorylation level of Erk1/2 in intervention group was significantly lower than that in the control group (P<0.01), no significantly difference was observed in the expression of Erk1/2, Akt and p-Akt in the two groups (P>0.05). Conclusion: The results of this study show that curcumin can inhibit the growth of tumor in vivo and inhibit the phosphorylation of Erk1/2 and inhibit the proliferation of human renal carcinoma cell line 786-O in nude mice.
2017 Vol. 47 (10): 735-738 [Abstract] ( 678 ) HTML (1 KB)  PDF (1668 KB)  ( 950 )
739 The effects of miR-152 on transforming growth factor-beta1-mediated epithelial-mesenchymal transition in human bronchial epithelial cells
ZHU Ronghe, SUN Yuanyuan, QIAN Yan.
Objective: To verify whether transforming growth factor-beta1 (TGF-β1) could induce epithelial-mesenchymal transition (EMT) in vitro and to determine the role of miR-152 in TGF-β1-mediated EMT in bronchial epithelial cells. Methods: 10 ng/mL of TGF-β1 was used to induce the EMT of human bronchial epithelial cells 16HBE. Morphological changes were observed and qRT-PCR and Western blot were employed to test the alteration of αSMA, E-cadherin and Vimentin, thus to verify the occurrence of EMT. qRT-PCR was then used to test the expression profile of miR-152 in TGF-β1 treated 16HBE cells. After miR-152 was successfully transfected into 16HBE cells, EMT related markers were then detected using qRT-PCR and Western blot. Results: Compared with control group, TGF-β1-treated cells presented a myofibroblast-like morphology, especially at 72 h, characteristic by the loss of cell-to-cell junction, denovo expression of α-SMA and Vimentin, and loss of epithelial marker E-cadherin (P<0.01). The expression levels of miR-152 in TGF-β1 treated 16HBE cells were dramatically increased after transfected with miR-152 mimics (P<0.01). Compared with the control group, α-SMA and Vimentin were decreased, whereas E-cadherin was increased in the miR-152 group (P<0.01), suggesting overexpression of miR-152 could reverse the EMT induced by TGF-β1 in 16HBE cells. Conclusion: TGF-β1 induces EMT of human bronchial epithelial cells in vitro; miR-152 inhibits TGF-β1-mediated EMT in 16HBE cells.
2017 Vol. 47 (10): 739-743 [Abstract] ( 596 ) HTML (1 KB)  PDF (1523 KB)  ( 837 )
744 The effect of salidroside on mitophagy induced by oxygen-glucose deprivation in astrocytes
ZHENG Liyun, HUANG Huifen, QIU Weiwen.
Objective: To investigate the effect of salidroside (Sal) on mitophagy induced by oxygen-glucose deprivation (OGD) in astrocytes. Methods: The primary astrocytes were isolated from cerebral cortex of neonatal rats and subjected to OGD for imitating hypoxia and glucose deprivation model in vitro. Cells were divided into sham group, OGD model group and Sal pretreatment+OGD group (Sal+OGD). Cell survival rate was detected with MTT and LDH leakage was analyzed with lactate dehydrogenase activity assay kit. Western blot was used to detect the expression of autophagy related protein. Results: The survival rate of cells with final concentration of 75, 150, 300 mol/mL Sal pretreatment and OGD were 83.15%±5.42%, 86.75%±4.91%, 91.41%±5.38%, which were significantly higher than that of the model group (71.22%±8.13%) (P<0.05), but still lower than that of the control group (99.39%±2.17%), the difference was statistically significant (P<0.05). Meanwhile, the LDH leakage rate of cell with final concentration of 75, 150, 300 mol/mL Sal pretreatment were 34.61%±5.19%, 30.51%±8.15%, 27.34%±7.41%, which was significantly lower than that of model group (40.51%±8.15%), but still higher than that of the control group (16.68%±3.69%), the difference was statistically significant (P<0.05). Western blot showed the expression of LC3, Beclin1, PINK1 and Parkin protein in the Sal+OGD group significantly lower than that in model group, but still higher than that in the control group (P<0.05). Conclusion: Sal decreases mitophagy related protein and restored the cell proliferation inhibition induced by OGD in astrocytes.
2017 Vol. 47 (10): 744-747 [Abstract] ( 723 ) HTML (1 KB)  PDF (1519 KB)  ( 847 )
748 The effects of different doses of oxycodone combined with propofol on hysteroscopy
MIAO Xianghui, LI He, JIANG Hui, WU Yanqin, LIN Han2
Objective: To compare the efficacy of different doses of oxycodone combined with propofol and explore the appropriate dose of oxycodone for hysteroscopy. Methods: Sixty patients who were scheduled for hysteroscopy were randomly divided into 4 groups (n=15 each): three oxycodone plus propofol groups (group O1, group O2, group O3) and propofol group (group P). In Groups O1, O2 and O3, oxycodone 0.05, 0.1, 0.15 mg/kg were injected respectively. Normal saline 0.15 mL/kg was bolused in Group P. Subsequentlythe hysteroscope was inserted until loss of response with intravenous administration of propofol, followed by a continuous infusion of propofol until the withdrawal of hysteroscope. At each time point, SBP, DBP, HR, and SpO2 were recorded. Propofol induced dosage, maintenance dosage, total dosage, total propofol administration time, the consumption of propofol per minute, operation time, emergence time, discharge time, the incidence of adverse reactions during intraoperative and postoperative and VAS scores were recorded. Results: There was no significant difference in the operation time, maintenance dosage and the incidence of hypotension, bradycardia, body movement, and nausea and vomiting between the four groups. Compared with group P, propofol induced dosage, the consumption of propofol per minute and VAS scores were significantly decreased in groups O2 and O3, emergence time was significantly decreased in groups O1, O2 and O3, and the incidence of dizziness was significantly increased in group O3 (P<0.05). Compared with group O1, propofol induced dosage, the consumption of propofol per minute and emergence time were significantly decreased in groups O2 and O3, and VAS scores was significantly decreased in group O3 (P<0.05). Propofol induced dosage was lower in group O3 than that in group O2 (P<0.05). The incidence of oxygen desaturation was higher and discharge time was longer in group O3 than that in groups P, O1 and O2 (P<0.05). Conclusion: The optimum dose of oxycodone is 0.1 mg/kg when combined with propofol for hysteroscopy.
2017 Vol. 47 (10): 748-751 [Abstract] ( 605 ) HTML (1 KB)  PDF (1252 KB)  ( 1202 )
752 Safety of norepinephrine versus dopamine in the treatment of cardiogenic shock: A meta-analysis
JIN Guangyong, LIN Leqing, ZHOU Menglu. WANG Bin, WANG Baiyong.
Objective: To systematically evaluate the safety of norepinephrine versus dopamine for the treatment of cardiogenic shock. Methods: Clinical trials of norepinephrine versus dopamine in cardiogenic shock were selected from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP Data.Study selection, assessment of methodological quality and data extraction were undertaken by two investigators separately, according to the inclusion and exclusion criteria. Meta analysis was performed using Review Manager 5.3 software. Results: A total of seven clinical trials with 381 patients were included. The results of this meta-analysis showed that norepinephrine for the treatment of cardiogenic shock reduced 28-day mortality by 0.54 times, compared to dopamine (RR=0.54, 95%CI: 0.37~0.80, P=0.002). The incidence rate of arrhythmia in norepinephrine group was 0.27 fold than that in dopamine group (RR=0.27, 95%CI: 0.16~0.48, P<0.001). Conclusion: Norepinephrine is safe in the treatment of patients with cardiogenic shock, compared to dopamine.
2017 Vol. 47 (10): 752-757 [Abstract] ( 738 ) HTML (1 KB)  PDF (1689 KB)  ( 987 )
758 Safety evaluation of dexmedetomidine in the pediatric patients undergoing removal of airway foreign body
HUANG Congcong, XU Fengyan, WU Biyun, LI Jun.
Objective: To evaluate the safety of dexmedetomidine on pediatric patients undergoing removal of airway foreign body. Methods: Randomized controlled trials (RCTs) about the pediatric patients undergoning removal of airway foreign body receiving intravenous infusion of dexmedetomidine were searched in The Cochrane Library, Medline, CNKI, VIP, CBM up to March 2016. The methodological quality of the included literatures were evaluated, and meta-analyses were performed with The Cochrane Collaboration’s RevMan 5.0 software. Results: A total of 4 RCTs involving 227 pediatric patients were included. The results of meta-analyses showed: ①Dexmedetomidine significantly reduced the coughing ratio (OR=0.44, 95%CI: 0.21-0.92, P<0.05); ②Dexmedetomidine significantly reduced the airway-spasm ratio (OR=0.21, 95%CI: 0.05-0.86, P<0.05); ③Dexmedetomidine did not significantly reduce the breath holding ratio (OR=0.50, 95%CI: 0.22-1.14, P>0.05); ④Dexmedetomidine significantly reduced the airway-spasm ratio (OR=0.44, 95%CI: 0.21-0.92, P<0.05). Conclusion: Dexmedetomidine is a safe anesthestic for airway foreign body removal in children from general anesthesia, decreasing the perioperative respiratory adverse events (coughing, airway-spasm, hypoxemia). However, because of the limited quality of the included researchs, further verification with more high quality RCTs are needed.
2017 Vol. 47 (10): 758-761 [Abstract] ( 654 ) HTML (1 KB)  PDF (1433 KB)  ( 793 )
762 The clinical curative effect of PPH combined haemorrhoidectomy in the treatment of mixed hemorrhoids
ZOU Liangwang, XU Lijuan, ZHANG Wei, SHAN Yunfeng
Objective: To explore the clinical curative effect of patients with mixed hemorrhoids who underwent the surgical treatment of procedure for prolapsed and hemorihoids (PPH) combined haemorrhoidectomy. Methods: Ninety-four patients with mixed hemorrhoid from Wenzhou Longwan First People’s Hospital in October 2013 to April 2016 were included. All of the 94 patients with mixed hemorrhoid were divided into treatment group (46 cases) and control group (48 cases). The treatment group underwent PPH combined haemorrhoidectomy, while the control group underwent Milligan-Morgan. Then the operation duration, intraoperative blood loss, postoperative wound bleeding, postoperative defecate difficulty, postoperative days of indwelling a urinary catheter, the postoperative pain scores of the anus, hospitalization cost and the follow-up of relapse, etc. were compared between two groups. Results: Two groups of patients all were discharged from hospital. Although in the operation time, postoperative days of indwelling a urinary catheter and hospitalization cost of treatment group were inferior to that in control group (P<0.05), but the intraoperative blood loss, postoperative wound bleeding, postoperative defecate difficulty, the postoperative pain scores of the anus and the follow-up of relapse, etc. of treatment group were superior to that in control group (P<0.05). Conclusion: The clinical effect and security of PPH combined haemorrhoidectomy is more higher than that of conventional surgical treatment in mixed hemorrhoids.
2017 Vol. 47 (10): 762-765,770 [Abstract] ( 568 ) HTML (1 KB)  PDF (2364 KB)  ( 833 )
766 The value analysis of ultrasound BI-RADS combined with ultrasound imaging in the diagnosis of breast masses
HONG Min, LI Yunting, HOU Chunjie.
Objective: To investigate the value of the breast imaging reporting and data analysis system (BI-RADS) combined with ultrasonic elastography (UE) in the breast masses diagnosis. Methods: 142 breast tumors were collected from125 cases of patients with breast tumors from January 2014 to December 2015, then we classified all breast masses by the ultrasonic BI-RADS, and had a ultrasound elastography (UE) examination, which the pathological results were used as the gold standard for diagnosis, to study the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of two methods single-handed and combined application. Results: There were 142 lesions in this study, of which 81 were benign lesions and 61 were malignant lesions. UE three law diagnosis results show that statistically significant differences in UE scores between benign and malignant breast lesions (P<0.05), the sensitivity of UE in diagnosis of malignant lesions was 78.69%, the specificity was 81.48%, the positive predictive value was 83.54%, the negative predictive value was 76.19%. BI-RADS classification results showed statistically significant differences in classification of benign and malignant breast lesions (P<0.05), the sensitivity of diagnosis of malignant lesions in BI-RADS classification was 72.13%, the specificity was 77.78%, the positive predictive value was 70.97%, the negative predictive value was 78.75%. On the basis of traditional ultrasonic BI-RADS classification combined with UE adjustment, the 2 methods were compared with the pre adjustment results, the difference was statistically significant (P<0.05). Conclusion: UE score method can improve the sensitivity and specificity of BI-RADS classification for diagnosis of benign and malignant breast lesions.
2017 Vol. 47 (10): 766-770 [Abstract] ( 715 ) HTML (1 KB)  PDF (1451 KB)  ( 902 )
771 Clinicopathological characteristics and therapy of 31 cases of papillary carcinoma of the breast
CAI Shibin, PAN Yin, MAO Weibo, ZHANG Min, CHEN Shuzheng.
Objective: To investigate the clinical and pathological characteristic, therapy method and prognosis in papillary carcinoma of the breast. Methods: The clinical data of 31 cases of patients with breast papillary carcinoma admitted to Lishui Central Hospital from August 2010 to December 2016 were retrospectively analyzed. All cases were performed hematoxylin-eosin (HE) staining and immunohistochemical staining pathologic examination. And the expression of human epidermal growth factor receptor 2 (HER2) gene amplification was detected by fluorescence in situ hybridization. Results: The morbidity of breast papillary carcinoma accounted for 2.71% of breast cancer at the same period, and in most cases painless bony mass in breast or papilla hemorrhagic discharge was discovered in initial diagnosis. Nine patients were undergone modified radical mastectomy, 18 cases were undergone total mastectomy plus sentinel lymph node biopsy (SLNB), and 1 case was undergone breast-conserving radical operation of mastocarcinoma and SLNB. After the operation, 7 cases received adjuvant chemotherapy, 2 cases received radiotherapy and all patients were undergone endocrine therapy. 25 cases had negative result in axillary lymph nodes. 31 cases expressed estrogen receptor or progesterone receptor and 29 cases had negative result in the expression of HER2. The follow-up time was 6 to 80 months, 1 case showed lumbar vertebra metastases in whole-body bone scanning. Other patients had disease free survival and had good living quality. Conclusion: The treatment and prognosis of breast papillary carcinoma are closely related to the pathological pattern. Intraductal papillary carcinoma, encapsulated papillary carcinoma and solid papillary carcinoma have good prognosis and can be dealt with in accordance with the therapeutic principle of carcinoma in situ.
2017 Vol. 47 (10): 771-774 [Abstract] ( 723 ) HTML (1 KB)  PDF (1300 KB)  ( 792 )
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