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2016 Vol. 46, No. 5 Published: 2016-05-25   313 Maresin 1 strengthen macrophages phagocytosis via miR-340 XIE Haiqing, ZHANG Junli, XIE Xiang, JIN Shengwei. Objective: To investigate whether Maresin 1 (MaR1) could strengthen macrophage phagocytosis in sepsis model, and to explore the underlying mechanisms. Methods: Mouse peritoneal macrophages and bone marrow-derived macrophages (BMDMs) were assessed through detection of F4/80 expression by fluorescence microscopy and flow cytometry. MiR-340 expression was investigated under the treatment of MaR1 in CLP-induced and LPS-induced sepsis model in vivo and in vitro. MiR-340 expression in BMDMs transfected with miR-340 mimic or inhibitor was detected by quantificational real-time polymerase chain reaction (qRT-PCR). And then, the effect of miR-340 on phagocytosis of macrophage was investigated with fluorescence microscopy and flow cytometry. Finally, miR-340 serum concentration in sepsis patients and in healthy volunteers was measured. Results: Mouse peritoneal macropha-ges and BMDMs were consisted of approximately 90% as assessed by F4/80 expression. MiR-340 expression was up-regulated in LPS challenging and down-regulated with MaR1 administration in vivo and in vitro (P<0.05). MiR-340 expression was up-regulated in BMDMs transfected with miR-340 mimic, however dose not down-regulated in BMDMs transfected with miR-340 inhibitor. The phagocytosis of mouse peritoneal macrophages transfected with miR-340 mimic was suppressed by fluorescence microscopy (P<0.05); Similarly, the function of BMDMs transfected with miR-340 mimic was refrained by flow cytometry (P<0.05). MiR-340 serum concentration was elevated in sepsis patients (P<0.05). Conclusion: MaR1 can strengthen macrophage phagocytosis via miR-340 in sepsis. 2016 Vol. 46 (5): 313-320,325 [Abstract] ( 1778 ) HTML (1 KB)  PDF (3487 KB)  ( 1314 ) 321 Study on the expression of RhoA/Rho-kinase and eNOS in vascular endothelial cells under hypoxic condition JIN Hongguo, ZHOU Min, JIN Meiyu, KOU Xuelian, HE Songbin, TANG Weiguo. Objective: To establish stable hypoxic model in vitro and to explore the effect of RhoA protein/Rho-kinase in human umbilical vein endothelial cell, (HUVEC) on eNOS expression of its endothelial cell under hypoxic condition. Methods: SH-SY5Y cells, HEK293 cells and HUVEC were respectively transfected using jet-PEI-HUVEC and siRNA to prepare cellular hypoxic model, the Western blotting analysis was preformed for the related proteins through cellular lysis. Results: RhoA protein levels in HUVEC were low under normoxic conditions, but were significantly increased after 5 h of hypoxia. Endothelial Rho-kinase expression was not detected until 3 h of hypoxia; such expression remained significantly increased after 5 h. On the other hand, endothelial eNOS expres-sion was similar after 3 h of hypoxia, but was significantly decreased after 5 h. The hypoxia-induced decrease in eNOS expression was significantly enhan-ced by expression of the constitutively active form of RhoA and significantly inhibited by suppression of RhoA expression by small interfering RNA. The hypoxia-induced decrease in eNOS expression was significantly inhibited when endogenous Rho-kinase activation was inhibited by Rho-binding domain expression. Conclusion: Expression and activation of RhoA and Rho-kinase inhibit eNOS expression in endothelial cells, attempts to down-regulate RhoA and Rho-kinase by multiple drugs, such as statins or Rho-kinase inhibitors, might provide endothelial and cardiovascular benefits through upregulation of eNOS. 2016 Vol. 46 (5): 321-325 [Abstract] ( 1294 ) HTML (1 KB)  PDF (1475 KB)  ( 878 ) 326 Effect of epinephrine on inhibition of sodium current induced by bupivacaine in ventricular myocytes of rats Objective: To determine the effect of epinephrine on inhibition of sodium current (INa) induced by bupivacaine inventricular myocytes of rats. Methods: The ventricular myocytes isolated from Sprague-Dawley rats by acute enzymatic dissociation were randomly divided into two groups (n=5). The whole-cell patch clamp technique was used to record INa in single ventricular myocytes and the effect of 0.15 ug/mL epinephrine inhibition of INa on induced by 40 or 50 μmol/L bupivacaine were observed. Results: The inhibition rates of 40 μmol/L bupivacaine or 50 μmol/L bupivacaine on INa was 50.2%±5.8 % or 62.7%±7.7 % (P<0.05) respectively. After the administration of 0.15 ug/mL epinephrine, the inhibition rates in the 40 μmol/L bupivacaine group changed to be 33.7%±10.2 % (P<0.05), and which was 62.1%±7.3% (P>0.05) in the 50 μmol/L bupivacaine group. Epinephrine did not shift the I-V curve. Conclusion:Epinephrine can reverse inhibition of INa induced by low-concentration bupivacaine. This effect of epinephrine will be limited to a higher level concentration of bupivacaine. 2016 Vol. 46 (5): 326-329 [Abstract] ( 829 ) HTML (1 KB)  PDF (1505 KB)  ( 894 ) 330 Analysis of clinicopathology and outcome of childhood Henoch-Schonlein purpura nephritis with endocapillary proliferation FU Gui, HE Xiaoqing, HU Yunxia, YU Lingfang, YANG Qing, ZHUANG Jieqiu. Objective: To investigate the clinicopathogical characteristics and outcome of Henoch-Schonlein purpura nephritis with endocapillary proliferation (EP-HSPN) in children. Methods: Retrospectively analyzed the clinicopathology and follow-up data of children whom were biopsy-proven EP-HSPN in our hospital from January 2005 to June 2013, and the contemporary non-EP-HSPN children were chosen as control group. Further comparisons among the EP-HSPN cases were performed. Results: ①In contrast to the 44 cases of non-EP-HSPN group, the 46 cases of EP-HSPN group showed younger, a shorter course of disease, joint and gastrointestinal tract more presented involvement, nephrotic level of proteinuria, hypoalbuminemia, nephrotic syndrome type, grade III lesion, a higher rate of crescent and capillary loops necrosis, but slighter damage of renal tubular interstitial. ②In 46 cases in children with EP-HSPN, compared with the 33 cases of non-DEP-HSPN, 13 cases of DEP-HSPN had heavy proteinuria, higher BUN, more showed nephrotic level of proteinuria, hypoalbuminemia and nephrotic syndrome type, less presented hematuria and proteinuria type. ③For EP-HSPN children, more given steroid in combination with cyclophospamide treatment (50%), whereas for non-EP-HSPN, more given symptomatic treatment (47.7%). The follow-up results of two groups showed no statistically significant differences in outcome. Conclusion: EP-HSPN shows severity of clinical manifestations and glomerular pathological changes. Immunosuppressant treatment in the early stage of disease is effective for a short term outcome. 2016 Vol. 46 (5): 330-334 [Abstract] ( 876 ) HTML (1 KB)  PDF (1250 KB)  ( 831 ) 335 Screening and verification of circulating miRNA biomarkers of rheumatoid arthritis PENG Wujian, WANG Hongle, HUANG Jianrong, DAI Yong. Objective: To analyze the differentl expression of circulating microRNAs (miRNAs) in patients with rheumatoid arthritis (RA). Methods: MiRNA profiles were performed to determine the differentially expressed miRNAs using RNA obtained from the plasma of patients with RA and healthy controls; to confirm array results, RT-qPCR was used for validation. GeneSpring GX software was to data processing, t-test and one way ANOVA were used for statistical analysis. Results: The array analysis identified 40 (18 upregulated miRNAs and 22 downregulated miRNAs) circulating miRNAs significantly differently expressed between RA and healthy controls, then we detected the candidate miRNAs selected based on fold-change and potential value by RT-qPCR, consistented with the data obtained from the array, the circulating level of candidate miRNAs were significantly differed in patients with RA compared with healthy controls (P<0.05). Conclusion: Differently expressed circulating miRNAs can be detected in patients with RA, this study indicates that circulating miRNAs may be used as a potential candidate biomarker of RA. 2016 Vol. 46 (5): 335-339 [Abstract] ( 861 ) HTML (1 KB)  PDF (1354 KB)  ( 1020 ) 340 The effects of naoxintong on vascular smooth muscle cells proliferation and autophagy induced by oxidized low-density lipoprotein QIU Weiwen, ZHENG Liyun, WU Zhiping, CAI Xueli, PENG Xiao, HUANG Yuejin, HUANG Liangtong. Objective: To investigate the effects of naoxintong on the vascular smooth muscle cells (VSMC) proliferation and the expression of Beclin1 and LC3 induced by oxidized low-density lipoprotein (ox-LDL). Methods: The VSMC were divided into four groups: control group, ox-LDL group, naoxintong group and ox-LDL+naoxintong group. MTT and colony formation assay was used to test the proliferation. Western blot was used to analysis the expression of Beclin1 and LC3. Results: ox-LDL significantly promoted the viability and colony formation of VSMC. Naoxintong had no effect on the proliferation and colony formation but inhibited the proliferation and colony formation of VSMC induced by ox-LDL. Western blot results demonstrated that ox-LDL significantly promoted the expression of Becli1 and LC3, naoxintong inhibited the expression of Beclin1 and LC3 induced by ox-LDL. Furthermore, MTT verified that autophagy inhibitors 3MA inhibited significantly the proliferation induced by ox-LDL. Conclusion: Naoxintong inhibited the VSMC proliferation induced by ox-LDL through inhibited the cell autophagy. 2016 Vol. 46 (5): 340-343,347 [Abstract] ( 859 ) HTML (1 KB)  PDF (2526 KB)  ( 1033 ) 344 Effects of hydrogen sulfide on coagulation dysfunction in rats with intestinal ischemia-reperfusion injury LU Genlin, WU Aibing, WANG Hongbin. Objective: To study the effects of hydrogen sulfide on coagulation dysfunction in rats with intestinal ischemia-reperfusion injury and its mechanism. Methods: Twenty-four male Wistar rats were randomly divided into three groups (8 in each group): sham operation group (group A), ischemia-reperfusion group (group B), ischemia-reperfusion and sodium hydrosulfide group (group C). The animal model of intestinal ischemia-reperfusion was established. Rats in Group C were received sodium hydrosulfide (100 μmol/kg bolus+1 mg·kg-1·h-1 infusion) 10 min prior to the onset of reperfusion. Expressions of PAR-1 and PAR-3 were detected by RT-PCR and flow cytometry. Serum H2S was tested by sensitive sulfide electrode. Serum TF, TNF-α, t-PA, PAI-1 were determined by ELISA. PLG:A, FVIII:C, vWF, AT:A, platelet were measured. Results: PAR-1, PAR-1 mRNA, TF, TNF-α, FVIII:C, vWF, t-PA, PAI-1 in group C were significantly higher than those in group A, predominantly lower than those in group B (P<0.01). H2S, PLG:A, AT:A in group C were sharply higher than those in group B, strikingly lower than those in group A (P<0.01). H2S negatively correlated with PAR-1, PAR-1 mRNA, TF, TNF-α, FVIII:C, vWF, t-PA, PAI-1 (r=-0.58, -0.68, -0.62, -0.64, -0.73, -0.55, -0.57, -0.64, P<0.01), positively correlating with PLG:A, AT:A (r=0.57, 0.61, P<0.01). Conclusion: H2S attenuates coagulation dysfunction in rats with intestinal ischemia-reperfusion injury by down-regulating PAR-1, TF, TNF-α. 2016 Vol. 46 (5): 344-347 [Abstract] ( 976 ) HTML (1 KB)  PDF (1346 KB)  ( 1058 ) 348 Study on interaction of depression, anxiety and intestinal inflammation XU Xiaoxiao, WU Feiyan, FEI Ning, LIAN Lejing, PAN Jianchun Objective: To investigate the interaction and the potential mechanism of stress and intestinal inflammation. Methods: Stress model was established by eight different stress factors within 21 days, The intestinal inflammation group was established by anal enema (TNBS), stress combined with intestinal inflammation model were established by the combination of two models above. From 22 days, all rats were given behavioral tests, including forced swimming test (FST), the marble burying test, the number of fecal output and AWR test, then rats were sacrificed. The expressions of BDNF and phosphorylated cAMP in the hippocampus and frontal cortex, IL-1β, IL-6 in the ileum and colon were detected by Western Blotting. Results: The freezing time of stressed combined with intestinal infection group was significantly lower in FST, the number of marbles buried in marble burying test was also significantly lower, the number of fecal output and the score of AWR were obviously reduced when compared with merely chronic stress group or merely intestinal inflammation group. The expression of BDNF and p-CREB were reduced more significantly whether in the hippocampus or frontal cortex. The expression of IL-1β and IL-6 increased more significantly whether in the ileum or colon when compared with merely chronic stress group or merely intestinal inflammation group. Conclusion: Depression or anxiety as psychological factors, has certain interaction with intestinal inflammation. depression and anxiety emotions can increase the intestinal disorders, and the intestinal disorders can exacerbate depression or anxiety emotions also. The mechanism may be involved with enteric nervous system and central nervous system, the two system play the role by regulate the braingut peptide. 2016 Vol. 46 (5): 348-353,358 [Abstract] ( 694 ) HTML (1 KB)  PDF (3638 KB)  ( 1110 ) 354 Effect of magnesium on calcification of human vascular smooth muscle cells SUN Wenxue, ZHANG Objective: To investigate the effect of magnesium on calcification of vascular smooth muscle cells (VSMCs) induced by elevated calcium (Ca++) and phosphate (P) culture. Methods: The fetus’s umbilical artery VSMCs were extracted under aseptic conditions and cultured in vitro. Cells were divided into three groups: normal control group (normal concentration of Ca++ and P, group A), positive control group (high calcium and phosphate, group B), treatment groups (high calcium and phosphate + magnesium sulfate, group C). The cells were cultured for 3 days, then Part (B1, C1) were continued to develop in high calcium and phosphate culture medium, Part (B2, C2) were changed to develop in ordinary solution. Respectively the calcium content of cell layer were determinated in calcium content test in the 4, 7, 10 days. Meanwhile, the protein expression of Cbfa1 and Prps2 were observed by Western bloting. Results: The primary cells were identified, purity of cultures was assessed by positive immunostaining for α-SMA. Compared with negative control group, the sedimentary on the cells layer of experimental group (B) was observed. The calcium content in calcium content test showed that the high calcium and high phosphorus group (B, B1 and B2) increased significantly (P<0.05), compared with the B, B1 and B2 group, magnesium sulfate group (C, C1 and C2) showed a lower intracellular calcium levels. Western blot test results confirmed that: compared with control group (A), the expression of Cbfa1 increased in B group in 24 hours, 72 hours; compared with B group, the expression of Cbfa1 declined in C group in 12 hours, 24 hours, 72 hours. compared with B1, B2 group, the expression of Prps2 increased in C1, C2 group in 4 days, 7 days, 10 days, was statistically significant (P<0.05). Conclusion: High calcium and high phosphorus promote the VSMCs’ calcification. While magnesium has a significant effect to inhibit the VSMCs calcification, activate the Prps2 protein expression, promote the calcification fade. 2016 Vol. 46 (5): 354-358 [Abstract] ( 922 ) HTML (1 KB)  PDF (1339 KB)  ( 1146 ) 359 Analysis of the therapeutic effect and influence factors on percutaneous catheter drainage with continuous instillation for the treatment of bacterial liver abscess with diabetes mellitus XU Shihao, YING Li, LI Qiao, LIN Tuo, HU Yuanping. Objective: To compare the clinical value of two methodes of ultrasound guided percutaneous catheter drainage for the treatment of bacterial liver abscess with diabetes mellitus (continuous instillation and simple catheter drainage). Furthermore, the factors which could influence the postoperative extubation time and length of hospital stay were also identified. Methods: One hundred and seventy cases of diabetic patients with bacterial liver abscess were randomly divided into 2 groups, which were all under the ultrasound interventional treatment. Eighty-five patients underwent simple catheter drainage, and 85 patients underwent continuous instillation. Patients were followed up to assess the postoperative complications, postoperative body temperature and peripheral blood leukocyte returned to normal time, postoperative extubation time, and length of hospital stay. The factors which could influence the postoperative extubation time and length of hospital stay were also identified in instillation group, in which 85 cases underwent continuous instillation by ultrasound guided percutaneous hepatic puncture. In addition, a multicomponent prediction model for predicting postoperative extubation time and length of hospital stay were developed using LASSO regression. Results: There was no statistically significant between the two groups regarding the incidence of postoperative complications, peripheral blood leukocyte and postoperative body temperature returned to normal time (P>0.05). Postoperative extubation time in instillation group was (21.1±12.4) d, significantly shorter than that in drainage group (29.1±14.9) d (P<0.05), hospitalization time in instillation group was (16.2±6.6) d, also significantly shorter than that in drainage group (27.8±8.0) d (P<0.05). The influence factors of postoperative extubation time is: abscesses gas, locule number, combined biliary calculi, plasma albumin and body mass index (BMI) (P<0.05); The only influence factor for postoperative hospital stay was septic shock (P<0.05). The multicomponent prediction model for predicting postoperative extubation time=0.06 leukocyte -0.72 albumin+1.99 more room+6.86 biliary stones+0.94 BMI; postoperative hospital stay=0.21 triacylglycerol +1.79 septic shock. Conclusion: Continuous instillation was more effective than simple catheter drainage in the treatment of diabetic bacterial liver abscess. Ultrasound image characteristics of abscesses gas, locule number, patients with biliary calculi, hypoalbuminemia or high BMI will extend the postoperative extubation time, merge patients with septic shock will extend the postoperative hospital stay. 2016 Vol. 46 (5): 359-364 [Abstract] ( 735 ) HTML (1 KB)  PDF (1573 KB)  ( 908 ) 365 Follow-up of the prognosis of recurrent wheezing in early childhood and the risk factors of continued wheezing HU Xiaoguang, YU Hongmei, WU Qiuping, LIN Li, ZHANG Hailin, LI Changchong. Objective: To investigate the prognosis of recurrent wheezing in children in their first 3 years of life and the risk factors of continued wheezing at school age; to determine the predict power of pediatric asthma predict index, and finally provide useful information for the prevention and treatment of asthma in childhood. Methods: Eligible patient: Children with “recurrent wheezing” less than 3 years of age who hospitalized in our hospital from January 1, 2009 to December 31, 2009. Basic data of enrolled patients were collected from our hospital’s digital medical record database. After then, we conducted prospective telephone interviews and clinical follow-up for 4 years after their hospital discharges to investigate their persistence of wheezing and present condition. Results: Totally 1 011 cases were screened, and 106 eligible patients were finally followed up. There were 30 (28%) of them still with episodes of wheezing for 4 years after their discharges from hospital. And 44.2% (23/52) of patients with positive modified asthma predict index (mAPI) had wheezing, which was significant higher than the 13% (7/54) in patients with negative mAPI (x²=13.26, P<0.01; OR 5.33, OR 95%CI: 2.03~13.97). The sensitivity of mAPI for prediction of continued wheezing was 76.7% (23/30), and specificity was 61.8% (47/76). According to univariate analysis, male (x²=5.26, P<0.05), physician diagnosed eczema (x²=8.17, P<0.01), food allergy (x²=7.25, P<0.01), no-infection induced wheezing (x²=22.95, P<0.01), and parent’s history of allergic rhinitis (x²=22.83, P<0.01) were correlated to continued wheezing. Subsequent multivariate logistic regress analysis revealed that physician diagnosed eczema, no-infection induced wheezing and family history of allergic rhinitis were the independent risk factors of continued wheezing. Conclusion: In our country, a positive mAPI score before 3 years may associated with 40% chance of continued wheezing at school age or even less; physician diagnosed eczema, non-infection induced wheezing, and family history of allergic rhinitis may be the important independent risk factors. 2016 Vol. 46 (5): 365-368 [Abstract] ( 657 ) HTML (1 KB)  PDF (1223 KB)  ( 925 ) 369 Analysis of lumbar vertebrae and the hips bone mineral density in 791 cases of Wenzhou city healthy adults MAO Chuanwan, ZHENG Wenlong, YU Zhikang, WU Aiqin Objective: To analyze the change regularities of bone mineral density (BMD) in lumbar vertebrae and the hips of healthy adults in Wenzhou area, establishing of a local region of BMD normal reference value, in order to provide reference for prevention and clinical treatment of osteoporosis. Methods: Used by dual energy X-ray absorptionetry (DXA), BMD of lumbar vertebrae (L1, L2, L3, L4, L1-4) and the hips in 791 cases of healthy adults in Wenzhou area was measured, statistical analysis was perfomed with SPSS18.0 software. Results: The peak of BMD in lumbar vertebrae and the hips occurred at the age of 20~29 in females and 30~39 in males. After reaching the peak of BMD, the BMD value decreased with growing age, and it reduced with increase of age. However, the rebound phenomenon of BMD value in lumbar vertebrae occurred in men after 60 years old. Conclusion: BMD data of healthy adult men and women in Wenzhou area can provide certain refrrence value for the diagnosis of osteoporosis in our region. 2016 Vol. 46 (5): 369-371 [Abstract] ( 769 ) HTML (1 KB)  PDF (1172 KB)  ( 1030 ) 372 Correlation between psychological states, coping styles and social support of primary caregivers of hospitalized stroke patients YANG Haiping, LI Jiang, CHEN Xiaoling, LI Haishan, GAO Qunyan Objective: To study the correlation between psychological state, coping styles and social support of primary caregivers of stroke patients. Methods: One hundred and sixty primary caregivers were screened out with the random sampling method for the investigation of their psychological states, coping styles and social support using IDA (irritability depression and anxiety scale), MCMQ (medical coping modes questionnaire) and SSRS (social support rating scale). Results: The IDA scores of primary caregiver of hospitalized stroke patients from high to low were anxiety, depression, inter-irritation and outer-irritation. The scores of positive coping styles, avoidance, and negative coping styles were 10.32±2.76, 18.39±3.24, and 15.08±2.96. The scores of social support from high to low were subjective support, objective support and utilization of support. There were significant differences between primary caregivers’s psychological state and coping styles in terms of all factors (P<0.05). The confrontation and avoidance in the primary caregivers were negatively correlated to the factors of IDA (P<0.05) and yielding in the coping style positively to the factors of IDA (P<0.05). Conclusion: The primary caregivers of stroke patients has serious psychological states problem on anxiety, depression and so on. The negative coping styles may promote the psychological states problem worse, while the positive may solve the problem. Therefore, the proper social support and nursing measures should be taken. 2016 Vol. 46 (5): 372-375 [Abstract] ( 709 ) HTML (1 KB)  PDF (1231 KB)  ( 1009 ) 376 Experience in treatment of epidural hematoma by minimally invasive drilling combined with urokinase perfusion drainage BAO Yongwu Objective: To explore the clinical effect of minimally invasive drilling and urokinase perfusion drainage in the treatment of epidural hematoma. Methods: Twenty-six patients with epidural hematoma in our hospital treated by minimally invasive drilling combined with urokinase perfusion drainage from October. 2013 to July 2015 were retrospectively studied. The puncture point was determine by CT. The maximum diameter of the direction of the hematoma was selected, avoiding vascular function area for minimally invasive drilling and indwelling of drainage tube. Urokinase perfusion drainage was performed postoperatively. Results: The hematoma disappeared after 72 hours of puncture, and the clinical symptoms of headache, vomiting and paralysis caused by epidural hematoma were relieved immediately. No hematoma was found after one months of follow-up. Conclusion: Minimally invasive drilling and urokinase perfusion drainage in the treatment of epidural hematoma trauma, which is simple operation, short operation duration, good effect, quick recovery, less bleeding, low cost, short time of hospitalization and worthy of clinical application. 2016 Vol. 46 (5): 376-378 [Abstract] ( 712 ) HTML (1 KB)  PDF (1286 KB)  ( 964 ) 379 Anatomical study on the bronchial artery with 320 row dynamic volume CT at high contrast injection rates ZHANG Xiaoqin, ZHAO Tian, RUAN Lei, WANG Zhenzhang, MAO Dandan, YANG Yunjun, SUN Objective: To evaluate the normal anatomical features and ectopic origination of the bronchial artery in patients with hemoptysis using 320 row dynamic volume CT (DVCT) at high contrast injection rates. Methods: From June 2014 to Sptember 2015, 173 patients with hemoptysis underwent BA angiography was included. The site of origin and distribution of BAs was then analyzed with transverse, MIP, VR and 3D fusion images. Results: From the 173 studied population, the most frequent type of BAs was II type (1R1L), which account for 37.0%. On the right side, 45.6% of BAs originated from intercostal-bronchial trunk (IBT); On the left side, 61.5% had BA with single origination. 45.1% of the studied population had at least one ectopic BAs. The most frequent sites of origin of ectopic BAs were the initial part of descending aorta, followed by the aortic arch. Conclusion: Even though the great variation and fine-calibrate of BAs, 320 DVCT at high contrast injection rate can preciously depicted the normal sites as well as ectopic origination of BAs, thus providing important anatomical information prior to therapeutic decision making of bronchial arterial embolization (BAE). 2016 Vol. 46 (5): 379-382 [Abstract] ( 636 ) HTML (1 KB)  PDF (1222 KB)  ( 863 ) 383 Efficacy and safety of dabigatran for secondary prevention of stroke in patients with non-valvular atrial fibrillation ZHENG Yangqin, YIN Weiyong, ZHOU Chengye Objective: To compare dabigatran and warfarin for secondary stroke prevention in nonvalvular atrial fibrillation patients in efficacy and safety. Methods: Patients diagnosed as ischemic stroke with NVAF in our hospital from January 2013 to January 2015 were continuously reviewed, which were divided into two groups, anticoagulated with dabigatran 110 mg twice daily and adjusted-dose warfarin. The occurrence of stroke and systemic embolism, any bleeding, adverse reactions were recorded. Results: Systemic embolism occurred in 11 patients on warfarin compared with 3 on dabigatran (P<0.05 for noninferiority). Has-bled was a predictor of major bleeding on warfarin (P<0.05), but not of dabigatran (P>0.05). Conclusion: In patients with NVAF, dabigatran given at a dose of 110 mg is associated with lower rates of systemic embolism. Has-bled may be not suitable for dabigatran, and it needs to be refined. 2016 Vol. 46 (5): 383-387 [Abstract] ( 662 ) HTML (1 KB)  PDF (1255 KB)  ( 1066 )

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