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2016 Vol. 46, No. 2 Published: 2016-02-25   79 Clinical features and prognosis of invasive tracheobronchial aspergillosis  in non-lung transplantation hosts SU Shanshan, ZHOU Ying, OUYANG Jinsheng, HE Haidong, LIN Pengcheng, WU Qing, LI Yuping Objective: To explore the clinical features and prognosis of invasive tracheobronchial aspergillosis (ITBA) in non-lung transplantation hosts. Methods: Nineteen cases of non-lung transplantation who admitted to the department of pulmonary and critical care medicine of the First Affiliated Hospital of Wenzhou Medical University from March 2002 to June 2015, for whom ITBA were confirmed by microbiologic culture and histopathology, were enrolled and all data were retrospectively analyzed. Results: Chronic respiratory diseases (CRD), diabetes mellitus and malignant tumor were the most common underlying diseases. ITBA could be diagnosed in immunocompetent host. In non-lung transplantation and non-malignant tumor hosts, at first, isolated tracheobronchitis was the most common manifestation, pseudomembranous form of ITBA was the major appearance under bronchoscopy. With the diseases progression, different features and extent of pulmonary involvement could be seen, ulcerative tracheobronchitis increased significantly, the total mortality was 52.6%, mortality increased to 100% when received mechanical ventilation. In patients with hematological malignancies, ITBA was often with IPA, under bronchoscopy, ulcerative and pseudomembranous forms of lobar bronchi were present in 2 cases, another patient of metastatic lung cancer who received radiotherapy, ITBA was also located in middle lobe and ulcerative form. Two of three patients died of massive hemoptysis. Conclusion: CRD, diabetes mellitus and malignant tumor are the most common underlying diseases of ITBA in non-lung transplantation hosts, it can also occur in immunocompetent host. Isolated tracheobronchitis and pseudomembranous form are the initial manifestations; In patients with hematological malignancies, ITBA is often with IPA, ulcerative and pseudomembranous forms of drainage bronchi were present. ITBA with underlying diseases have poor prognosis. 2016 Vol. 46 (2): 79-83,87 [Abstract] ( 1865 ) HTML (1 KB)  PDF (2624 KB)  ( 1020 ) 84 The effect of intrauterine growth on mental and psychomoter development in one-year-old discordant twins infants XIANG Huiqiu, HUANG Xianping, JIN Jiaxi, SHAO Haoran, CHI Meizhu, LIN Feng, XU Zhangye. Objective: To assess the effect of intrauterine growth on mental and psychomoter development in one-year-old discordant twins infants. Methods: Total of 34 discordant twin pregnancies (68 one-year-old discordant twins infants) with complete delivery records in Obstetrics department of the First and Second Affiliated Hospital of Wenzhou Medical University from January 2012 to December 2013 were followed-up. According to the discordant birthweight, each pair infant was divided into small weight group and large weight group. Weight, length, head circumferences, the mental developmental index (MDI) and psychomotor developmental index (PDI) were measured. Results: Small weight group was lower than that of large group at length, weight and head circumstance (P<0.05); PDI but not MDI was significantly different between two groups (P<0.05). Psychomotor retardation rates (PDI<70) were 17.6% in small weight group while 2.9% in large weight group (P<0.05). Stepwise regression analysis showed that the influence of height and weight of PDI had significant statistical significance (P<0.05). Conclusion: Intrauterine fetal growth and development leads to twins after birth weight differences, and sustained impact to born after 1 year old children’s height, weight and head circumference of physical growth and psychomotor development. 2016 Vol. 46 (2): 84-87 [Abstract] ( 778 ) HTML (1 KB)  PDF (1304 KB)  ( 1120 ) 88 Preparation and identification of a whole lung decellularized scaffold CHEN Chan, WANG Zhibin, WENG Jie, YU Qing, XU Enpan, CHEN Na, MENG Zhuo, DU Xiaohong, CHEN Shixin. Objective: To prepare a whole lung decellularized scaffold that was perfused with TritonX-100 and SDS, and to perform preliminary identification. Methods: Twenty SD rats were divided into two groups of 10 case in each randomly (decellularization and control group). Hearts and lungs were harvested from SD rats. In decellularization group, the arterial catheters were inserted through the aortopulmonary to establish channels for whole lung perfusion successively with heparinized PBS solution, 1% TirtonX-100, 0.8% SDS and deionized water in 37 ℃. The DNA concentration was determined after decellularization, and the scaffold and native lung were observed by HE staining, immunotluorescence and vascular cast. Results: Quantitative analysis of DNA content within the decellularized scaffold was (40.37±5.01) ng/mg, which showed a significant decrease compared to the native lung [(846.64±65.70) ng/mg]. A lot of collagen fibers could be observed with HE and immunohistochemistry stain but no visible cell nuclei remained after decellularization. Cast specimen showed that pulmonary arteries were still full and clear compared with the native lung. Conclusion: The method of perfusion with TritonX-100 and SDS can effectively remove all cellular components, and retain the extracellular matrix and vascular network structure well. It’s a convenient and ideal preparation method on decellularized lung scaffold for tissue engineering. 2016 Vol. 46 (2): 88-91 [Abstract] ( 783 ) HTML (1 KB)  PDF (1616 KB)  ( 1045 ) 92 Establishment and identification of human cervical cancer SiHa cells tumor bearing model in nude mice Hou Bailong, Du Wangqi, Xiong Yirong, Cai Yiqi, Song Yilin, Ling XiaoYun, Xue Xiangyang, Zhang Lifang Objective: To establish human cervical cancer SiHa cells tumor bearing model on the body surface area in nude mice, and analyze its tumor characteristics. Methods: Three groups nude mice were subcutaneous inoculated with 5×106/mL, 1×107/mL and 5×107/mL concentrations of cervical cancer SiHa cells in the right axillary close to upper limbs, to establish human cervical cancer SiHa cells tumor bearing model in nude mice. The tumor of nude mice was observed and the size of tumor was measured. The histological characteristics of tumor tissue was observed by pathological method after 5 weeks. HPV16E7 DNA of tumor tissue was comfirmed by PCR assay, and the expression of HPV16 E7 protein in tumor tissue was detected by immunohistochemistry method. Results: The tumor rate of 3 groups of nude mice inoculation with SiHa cell line was 100%. Their tumor sizes reached up (77.29±28.34) mm3, (178.91±61.55) mm3 and (305.11±12.62) mm3 after 5 weeks, and there was a significant difference among 3 groups (P<0.001). Pathology observation showed the growth of SiHa cell tumors were mainly in local infiltration. Histopathological of slice observation showed the new SiHa cells tumor tissue appeared pathological characteristics of large volume, large nucleus, nucleus deep dyeing and the mitotic phase. HPV16E7 DNA and the protein expression were positive comfirmed by PCR and immunohistochemistry detection respectively in tumor tissue. Conclusion: Human cervical cancer SiHa cells tumor bearing model in nude mice was established successfully, and provide an ideal animal model for human cervical cancer tumor targeted therapy and biological research.   2016 Vol. 46 (2): 92-96 [Abstract] ( 1135 ) HTML (1 KB)  PDF (1708 KB)  ( 2376 ) 97 The correlative analysis of PSMA6 rs1048990 single-nucleotide polymorphism and artery atherosclerosis cerebral infarction ZHAO Xiyao, HE Fangmei Objective: To investigate the correlation between rs1048990(-8C/G) polymorphism of proteasome subunit alpha type 6(PSMA6) gene and artery atherosclerosis cerebral infarction in Han population of the Shanxi province in China. Methods: By using a case-control method, 162 patients with artery atherosclerosis cerebral infarction (the case group) and 159 healthy controls over the same period (the control group) were selected in the study. The patients were in hospital of the department of neurology in the Affiliated Hospital of Xi’an Medical College from January 2012 to December 2013. The single nucleotide polymorphism of rs1048990 of PSMA6 gene was identified by the polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP), and genotype and allele frequency distributions in cerebral infarction patients and healthy controls were analyzed. Results: Compared with the control group, the difference of the frequency of GG genetype in the the case group wasn’t significant (P=0.054), the difference of the frequency of G allele wasn’t significant, either (P=0.05). After stratified by suffering from high blood pressure and diabetes, respectively, we didn’t find significant differences among all genotypes and alleles in the case group (all P>0.05); the same result had been found in the control group, too. After adjustment for known cerebral vascular risk factors by logistic regression analysis, the GG genotype of rs1048990 revealed no statistical significance between the case group and the control group (P=0.059). Conclusion: The rs1048990 of PSMA6 gene mayn’t be associated with the artery atherosclerosis cerebral infarction. But the P value approximate statistical significance, the single nucleotide polymorphism is worth further researches. 2016 Vol. 46 (2): 97-101 [Abstract] ( 717 ) HTML (1 KB)  PDF (1361 KB)  ( 960 ) 102 Association of vitamin D with pulmonary function and serum inflammatory factors in COPD JIANG Huanhuan, DAI Yuanrong Objective: To investigate the relationship between vitamin D and pulmonary function and serum inflammatory factors in patients with COPD. Methods: Twenty-seven healthy subjects, 30 patients with stable COPD and 34 patients with acute exacerbations of COPD were enrolled in our study. Serum level of 25-(OH)D was measured by the ECLIA. The expression of INF-γ and TNF-α were measured by ELISA, and IL-2, IL-4, IL-6, IL-10 were measured by FCM. All these subjects were compared among three groups. All patients of three groups performed pulmonary function tests. Correlations between 25-(OH)D and FEV1, INF-γ, TNF-α and IL-2, IL-4, IL-6, IL-10 were analyzed in stable COPD group and AECOPD group. Results: ①The levels of 25-(OH)D in AECOPD group and stable COPD group were significantly lower than those in control group (P<0.001). The level of 25-(OH)D in AECOPD group was significantly lower than that in stable COPD group (P<0.001). ②The prevalence of Vitamin D deficiency of AECOPD group and stable COPD group were higher than that of the control group (P<0.001), but there was no significant difference between AECOPD group and stable COPD (P=0.225). ③The level of 25-(OH) D was positively correlated with FEV1 in stable COPD group (r=0.524, P=0.005). ④The level of INF-γ of AECOPD group was significantly higher than those in stable COPD group (P<0.001). The level of INF-γ and IL-6 of AECOPD group was significantly higher than those in control group (both P<0.001). The level of IL-2 and IL-6 of stable COPD group was significantly higher than those in control group (P=0.024, P=0.007, respectively). ⑤There was no linear correlation between the level of 25-(OH) D and INF-γ, TNF-α, IL-2, IL-4, IL-6, IL-10 in patients with COPD. Conclusion: Vitamin D deficiency is highly prevalent to COPD patients, and the level of 25-(OH) D may be positively correlated with FEV1, but there was no linear correlation between the level of 25-(OH) D and serum inflammatory factors in patients with COPD. 2016 Vol. 46 (2): 102-105,111 [Abstract] ( 705 ) HTML (1 KB)  PDF (2478 KB)  ( 991 ) 106 Characteristic analysis of air- and bone-conducted tone-burst evoked auditory brainstem response in normal adults WANG Jingbo, JIN Lanlan, CHEN Jun, CHEN Xiaoyun, LIAO Zhisu Objective: To analyse the characteristics of air- and bone-conducted tone-burst evoked auditory brainstem response (ABR) recorded in adults with normal hearing, to compare tone-burst ABR thresholds with pure tone behavioral thresholds and to investigate the value of air- and bone-conducted tone-burst ABR thresholds. Methods: Thirty otologically normal persons (male/female=14/16) accepted pure tone audiometry, air- and bone-conducted click evoked ABR and tone-burst evoked ABR. Results: ①Thresholds of air-conducted tone-burst ABR for 0.5, 1, 2 and 4 kHz were 18.41±4.47, 13.18±3.63, 8.86±5.10, 8.64±5.16 dB higher than the pure tone behavioral thresholds respectively; thresholds of bone-conducted tone-burst ABR for 0.5, 1, 2 and 4 kHz were 14.31±3.98, 10.45±4.54, 6.82±4.24, 8.18±4.77 dB higher than the pure tone behavioral thresholds respectively. ②The differences between the air- and bone- conducted tone-burst ABR thresholds for 0.5, 1, 2 and 4 kHz were 5.55±3.42, 3.86±4.86, 1.36±5.60, 1.59±6.05 dB. The differences for 0.5, 1 kHz were statistically significant (P<0.01); the differences for 2, 4 kHz had no statistically significance (P>0.05). ③The wave V latencies of air- and bone-conducted tone-burst evoked ABR were significantly longer than those of click evoked ABR (P<0.01), but there was no significant difference for I～V interval (P>0.05). Conclusion: The thresholds of air- and bone-conducted tone-burst evoked ABR are useful in estimating the pure tone behavioral thresholds. The differences between the air- and bone-conducted tone-burst ABR thresholds may be helpful in differentiating the type of hearing loss. 2016 Vol. 46 (2): 106-111 [Abstract] ( 664 ) HTML (1 KB)  PDF (1585 KB)  ( 1254 ) 112 The influence of age and ovarian stimulation on oocyte utilization ZHENG Yi, WANG Haiqing, ZHOU Ying. Objective: To explore the effect of live birth per cycle, number of live births per mature oocyte and the number of mature oocytes per live birth according to ovarian ageing and ovarian response. Methods: A total of 1637 ICSI-ET cycles from January 2012 to February 2014 in Reproductive Medicine Center of the First Affiliated Hospital of Wenzhou Medical College were retrospectively analyzed. Live birth per cycle, number of live births per mature oocyte and number of mature oocytes per live birth were further analysed in relation to the age or ovarian response. The clinical outcomes were compared. Results: The data presented in this study showed that the number of live births per mature oocyte and the number of oocytes per live birth remained remarkably stable between the age of 23 and 37 years. After the age of 37 years number of live births per mature oocyte began to decrease gradually but from 40 years of age it dropped dramatically, and the number of mature oocytes per live birth increased. On the other hand, the pregnancy rate per cycle increased with the number of retrieved oocytes, so the pregnancy rate per cycle was highly dependent on ovarian response. Compared between the three ovarian response group, number of live births per mature oocyte was lower (P<0.01) and the the number of oocytes per live birth was higher (P<0.01) in the response group with more mature oocytes, which indicated that the ovarian stimulation might affect the reproductive potential of the individual oocyte. Conclusion: These data are extremely valuable as they provide information on the expected outcome in women undergoing fertility preservation. Moreover, it is crucial in the prediction of IVF success and patient counseling and considering the launching oocyte freezing for fertility preservation in our center. 2016 Vol. 46 (2): 112-117 [Abstract] ( 639 ) HTML (1 KB)  PDF (1509 KB)  ( 1107 ) 118 Determination of cognitive function of patients with coronary heart disease based on RBANS and related factors LIANG Yan, LI Lifeng, CHEN Jing, HUANG Hanjin. Objective: To detect the feature of cognitive function among patients with coronary heart disease using the repeated neuropsychological test and to study potential factors influencing RBANS score. Methods: Thirty-eight patients with coronary heart disease, who were from Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University and the Second Affiliated Hospital of Wenzhou Medical University, and 32 normal subjects for comparison were both tested using RBANS, HAMA, HAMD, Type D scale-14 during March 2012 to October 2012. The degree of coronary atherosclerosis, grading of cardiac function named NYHA, echocardiography, biochemistry of blood were tested, too. Results: In RBANS test, the scores of patient group were lower than that of the control group in total scale of RBANS, immediate memory, visual span and delayed memory factor programs and the difference was statistically significant (P<0.05). The scores of anxiety, depression and type D personality in patient group were higher than that in the control group, the difference was statistically significant (P<0.05); In patient group, the stent number was negatively correlated with total score of RBANS test, the output of every stroke was negatively correlated with total score of RBANS test, immediate memory and visual span, the aortic root diameter was negatively correlated with immediate memory, the pulmonary artery pressure was positively correlated with attention, the heart rate was negatively correlated with attention. Conclusion: Patients with coronary heart disease may exist obvious cognitive dysfunction, which is mainly manifested in the immediate memory, visual span, delayed memory. The cognitive function of patients with coronary heart disease may be affected by patients’ emotion and personality, its cognitive dysfunction may exist certain relationships to stent number, output of each stroke, aortic root diameter, pulmonary artery pressure and heart rate. 2016 Vol. 46 (2): 118-121 [Abstract] ( 1017 ) HTML (1 KB)  PDF (1303 KB)  ( 2231 ) 122 Clinical evaluation of glass ionomer and resin-based sealant on partially erupted permanent first molars PAN Yangyang, ZHOU Haiyan, MEI Liqin, LI Qiao. Objective: To compare the retention and caries preventive effects of two fissure sealants (glass ionomer based GC Fuji VII and resin based 3M Concise) on the partially erupted permanent first molars. Methods: The bilateral partially erupted permanent first molar of 50 children were sealed by two different fissure sealants with a split-mouth design. Clinical evalution of the sealants was carried out to record retention and presence of caries (ICDAS II scores) at 3, 6 and 12 months after placement. The P-value was calculated using Wilcoxon matched-pairs signed-rank test). Results: The recall rate was 94% at 12 months. No satistically significant difference was found in retention rates between the two groups (P>0.05). However, the Fuji VII group showed lower ICDAS II scores than Concise group. Conclusion: GC Fuji VII may be a better choice for pit and fissure caries preventing of partially erupted molars. 2016 Vol. 46 (2): 122-125 [Abstract] ( 736 ) HTML (1 KB)  PDF (1362 KB)  ( 1154 ) 126 Compressive suture in the lower uterine segment treating intraoperative hemorrhage with placenta previa in cesarean section QIAN Min, DING Fulyu. ZHANG Shengyan, LIU Zhengjie,WEN Haiyan.  Objective: To evaluate the clinical application value of suture the lower uterine segment for placenta previa cesarean section hemorrhage. Methods: Forty cases of intraoperative hemorrhage with placenta previa were to meet the study selected in our department from September 2012 to May 2014. All cases were randomly divided into two groups: 20 cases were chosen as the observation group for suture the lower uterine segment. Twenty cases were chosen as the control group for ascending branch of uterine artery ligation. Blood loss, surgical duration, postoperative duration of hospital, puerperal infection, hysterectomy rates were compared. Results: ①There were difference about blood loss volume and volume of blood transfusion in two groups (P<0.05). No ststistical difference was found between the groups in transfusion rate (P>0.05). ②There was difference about surgical duration in two groups (P<0.05). ③There was significant differences about postoperative duration of hospital in two groups (P<0.01). ④Three cases with postpartum hemorrhage of refractoriness were performed subtotal hysterectomy in the control group. Both of the two group did not appear the puerperal infection and maternal death. At the postpartum follow-up, all women described normal lochia and involution of uterus was found in pelvic examination. All women referred resumption of normal periods. No complained of painful in the pelvis. Conclusion: The method of suture of the lower uterine segment is effective technique for treating cesarean section hemorrhage of placenta previa. It has the benefits of the easy operation, rapidly mastering, quick hemostatic, low transfusion, reducing postoperative duration of hospital stay and the preservation of uterus. It is worthy of clinical promotion. 2016 Vol. 46 (2): 126-129 [Abstract] ( 683 ) HTML (1 KB)  PDF (1299 KB)  ( 850 ) 129 Clinical value of  fetal prenasal thickness examination with ultrasonograpy to scann Down syndrome YE Feng, DONG Xueqin, BAI LilI, NI Jiana, XU Xueqin, CHEN Limin. Objective: To construct a reference range for fetal prenasal thickness of second trimester fetuses with prenatal ultrasonograpy and to explore the relationship between the thickness in fetuses with Down syndrome. To evaluate the clinical value of prenasal thickness in scanning Down syndrome. Methods: The fetal profile was acquired from 597 normal fetuses and 46 fetuses with trisomy 21 at 16～25 weeks’ gestation between February 2012 and February 2014. Two-dimensional ultrasound was used to obtain the exact mid-sagittal plane and the prenasal thickness between the anterior edge of the lowest part of the frontal bone (at the junction with the nasal bone when present) and the skin anteriorly. Results: In the normal group prenasal thickness increased with gestation from a mean of (2.2± 0.4) mm at 16 weeks to (4.7±0.5) mm at 25 weeks (r=0.725, P<0.001). In 32 (69.6%) cases of the trisomy-21 fetuses the prenasal thickness was above the 95th centile of the normal range. When prenasal thickness above the 95th centile of the normal range was used as a cut-off, the sensitivity for Down syndrome. was 69.6%, the specificity was 96.3%, the positive predictive value was 64.0%, the negative predictive value was 97.1%, the positive likelihood ratio was 19.0, the negative likelihood ratio was 0.32. Conclusion: Increased prenasal thickness is a high risk for DS and can be used as a prenatal ultrasonographic mark in scanning Down syndrome. 2016 Vol. 46 (2): 129-132 [Abstract] ( 750 ) HTML (1 KB)  PDF (1517 KB)  ( 1063 ) 133 Manifestation of MRI findings and pathologic correlative analysis of the ovarian dysgerminoma LIU Xuming, YAN Zhihan, CHEN Yanmei, QIU Qiande Objective: To explore the manifestation of MRI features of ovarian dysgerminoma. Methods: The clinical pathologic data and MRI findings in 13 patients with ovarian dysgerminoma confirmed by operation and pathologic examination were retrospectively analysed. The size, shape, density, signal, boundary, strengthen and the changes of the adjacent structure of the mass were observed. Results: The largest diameter in 8 cases was longer than 10 cm, and 10 cases showed lobulated in shape with clear boundary and intact capsule (n=8). The tumor mainly appeared as solid masses in shape with necrosis and cystic lesions (n=2). Many signal voids of vessel in tumors were observed in three cases. The tumor mainly showed long T1 and long T2 signal on MRI, slightly high signal on DWI maps, and slightly low signal on ADC maps. The signal were mainly uniform. Nine cases with low signal fiber interval in tumor, and the tumor were divided into nodulars by the fiber interval. The higher signal nodular shadows were observed in the tumor in five cases with low signal fiber interval. The tumor were mainly enhanced slightly in the arterial phase after the administration of Gd-DTPA, with a feature of “slowly coming into and slowly going out”. Many circuitous blood vessels were significantly enhanced in the venous phase. Conclusion: The ovarian dysgerminoma has certain MRI characteristics, and the tumor, the intratumoral low signal hyperdensity and nodules separated by the hyperdensity are helpful to the qualitative diagnosis of ovarian dysgerminoma. 2016 Vol. 46 (2): 133-136 [Abstract] ( 731 ) HTML (1 KB)  PDF (1624 KB)  ( 985 ) 137 The imaging manifestation in aged spinal tuberculosis ZHANG Zhijing, CHEN Jiuzun, ZHOU Shengfa, HE Jiawei, YU Zhikang. Objective: To investigate the imaging fingdings in aged spinal tuberculosis. Methods: Imaging findings of 43 elderly patients with spinal tuberculosis proved pathologically or clinically were analyzed retrospectively. Results: Eighty-one vertebral bodies were affected in total, including 11, 24, 42 and 4 vertebral bodies separately in the cervical, thoracic, lumbar and sacrococcygeal spine. Four cases were limited to a single vertebral body, 28 cases occurred in two adjacent vertebrae, and 20 cases involved multiple vertebral bodies. The X-ray features of the 35 patients mainly included: disc-space narrowing, vertebral bodies destruction or wedged, and spinal sequence disordering. Twenty-three of them were confirmed exactly, 7 cases were misdiagnosed, and 5 patients’ disease diagnoses were missed. The CT scan largely involved vertebral bodies destruction, abscess and sequestrum formation, paravertebral soft tissue swelling, intervertebral disc damaging and intervertebral space narrowing. Nineteen of them were proved accurately, 5 cases were misdiagnosed, and 2 patients diagnoses were missd. The major characteristics in MRI were vertebral body lesions (little low or low on T1W images, high on T2W images and visibly high on STIR), paraspinal soft tissue swelling and abscess informed. Also the dural sacs and spinal cord were compressed, intervertebral signal and shape changed. Sixteen cases were diagnosed correctly, 2 of them were misdiagnosed. Conclusion: The aged spinal tuberculosis which is difficult to distinguish from other diseases, e.g. spine degeneration, metastasis, is of special imaging  characteristics. Imaging studies combining together are helpful to  thoroughly observe and exactly diagnose the disease. 2016 Vol. 46 (2): 137-139 [Abstract] ( 908 ) HTML (1 KB)  PDF (1404 KB)  ( 933 ) 140 A clinical analysis of 55 cases of bronchiectasis in children in Wenzhou area JIN Weijing, ZHANG Lele, ZHANG Hailin, ZHANG Weixi, LI Changchong. Objective: To explore the etiology, imaging characteristics and pathogen distribution of the bronchiectasis children in Wenzhou. Methods: Datas of 55 patients with bronchiectasis from January 1997 to March 2013 were retrospectively analyzed. Results: The main cause of bronchiectasis in 34 cases was respiratory tract infection (61.82%). Other causes induded 2 cases of bronchial foreign bodies (3.64%), 2 cases of congenital immunodeficiency disease (3.64%), 2 cases of primary cilia dysfunction (3.64%), 3 cases of congenital respiratory system malformations (5.45%), 4 cases of bronchial asthma (7.27%), 1 case of allergic bronchial pulmonary aspergillosis (1.82%), 1 case of inflammatory bowel disease (1.82%), and 6 cases of unknown reasons. Eight cases (14.55%) had positive hints in Chest X-ray, while chest high-resolution CT (HRCT) was 100%, and the difference was statistically significant (x2=82.0, P<0.05). Sputum examination results of 35 (35%) were positive in 100 specimens. Pseudomonas aeruginosa was the most common (31.82%).  Conclusion: Respiratory tract infection is the most common cause of bronchiectasis in the Wenzhou area. HRCT is a major method of diagnosis. Gram-negative bacteria infection is the main pathogen, especially pseudomonas aeruginosa. 2016 Vol. 46 (2): 140-143 [Abstract] ( 819 ) HTML (1 KB)  PDF (1317 KB)  ( 820 ) 144 A retrospective analysis of one case of splenic abscess of typhoid fever secondary to primary myelofibrosis and review of literatures GUO Haifei, XU Yu, Jiang Lei, TU Xiaofang, WU Fangfang Objective: To analyze the clinical manifestations, diagnosis, treatment of the patient with splenic abscess of typhoid fever secondary to primary myelofibrosis. Methods: The clinical data, including baseline clinical data, clinical features, past history, pathogen culture result, treatment of the patient with splenic abscess of typhoid fever secondary to primary myelofibrosis retrieved from the Third Affiliated of Wenzhou Medical University were collected and analyzed and the literatures on this topic were reviewed. Results: Patients with PMF were vulnerable to infectious disease for some facts in the disease progresses, and when splenomegaly pathogen seemed more easy to colonize . In the case of Salmonella bacteremia, the patient with PMF seemed to have an increased frequency of evolving into splenic abscess of typhoid fever. Conclusion: The patients with splenic abscess of typhoid fever are clinically rare and easy to misdiagnose, clinician should increase the understanding of this disease. 2016 Vol. 46 (2): 144-146 [Abstract] ( 612 ) HTML (1 KB)  PDF (1414 KB)  ( 1001 )

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