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2015 Vol. 45, No. 5 Published: 2015-05-25   313 The genetic analysis of mitochondrial tRNAGln 4363 T > C mutation associated with essential hypertension in three Chinese Han pedigrees YU Han1, GENG Junwei1, LIN Zhi1, XUE Ling1, TANG Xiaowen1, ZHENG Binjiao1, LV Jianxin1, LU Zhongqiu1, GUAN Minxin1,3. Objective: To analyze and evaluate the clinical, genetic and molecular characteristics of mtDNA in three Han Chinese pedigrees with essential hypertension and explore the role of tRNAGln 4363T>C mutation in the development of those maternally inherited essential hypertension. Method: Mitochondrial tRNA gene of 848 Chinese Han essential hypertension subjects and 254 control subjects were amplified with PCR. Members of 3 Chinese Han pedigrees with mitochondrial tRNAGln 4363T>C mutation underwent mitochondrial DNA genetic analysis and pedigree assessment. Result: Three essential hypertension subjects were found with tRNAGln 4363T>C mutation, and with variable severity and age-of-onset in hypertension among the three pedigrees. The percentage of this mutation was 0.35%. Twelve of 28 matrilineal relatives in these families exhibited the variable degree of hypertension at the age at onset of 27 to 64 years old and at the average of 44 years old, while none of the offspring at affected father had hypertension. Sequence analysis of complete mitochondrial genomes in 3 pedigrees showed that, in addition to the homoplasmic 4363T>C mutation, there were also 64 other mutations, and the mtDNA polymorphisms belonged to haplogroups Z3, Z3 and B4d, respectively. The tRNAGln 4363T was localized at immediately 3’end to the anticodon, corresponding to highly conserved adenine at position 38 of tRNAGln, the 4363C>T mutation might affect the high fidelity of recognition and the formation and stability of normal tRNA structure. Conclusion: The occurrence of the tRNAGln 4363T>C mutation in three genetically unrelated pedigrees affected by hypertension and the absence in 254 Chinese controls strongly indicate that this mutation is associated with essential hypertension. The homoplasmic form, late onset and incomplete penetrance of hypertension observed in those Chinese pedigrees suggest that tRNAGln 4363T>C mutation may be insufficient to produce a clinical phenotype, nuclear modifier gene (s) or environmental factor (s) may play a role in the phenotypic expression of essential hypertension related to tRNAGln 4363T>C mutation. 2015 Vol. 45 (5): 313- [Abstract] ( 700 ) HTML (1 KB)  PDF (7328 KB)  ( 611 ) 321 MicroRNA-23a regulate the growth and migration of HUVECs in Kawasaki disease CHU Maoping1, HU Chen2, ZHOU Aihua2, WANG Huiying2, PAN Lulu3, QIU Huixian3, WU Rongzhou3, ZHAO Xianxian1. Objective: To study the effect of miR-23a that on the growth and migration of human umbilical vein endothelial cells (HUVECs) in Kawasaki disease. Methods: Real-time PCR was used to confirme miR-23a that differential expression between Kawasaki disease and controls. Bioinformatics analysis and the gene chip of inflammatory cytokine were used to target the genes. Transfect the miR-23a mimic/inhibitor in HUVECs.CCK-8 assay was used to measure the effect of proliferation. Cell scratch method and transwell chamber were performed to investigate the effect of migration. Results: MiR-23a was significantly higher in Kawasaki disease. The miR-23a mimic could promote the proliferation and migrate of HUVECs, the mi-23a inhibitor could inhibit the proliferation and migrate (P<0.05). Conclusion: The miR-23a play an important role in the development and progression of KD and could effect the proliferation and migrate of HUVECs. 2015 Vol. 45 (5): 321- [Abstract] ( 726 ) HTML (1 KB)  PDF (12369 KB)  ( 643 ) 327 Impacts of atorvastatin on expression of IL-17a, LP-PLA2 in low-density lipoprotein receptor knockout mice NI Yunjie1, LIN Zhenhao1, HOU Lianglei1, WU Yihao1, SONG Lijuan1, HU Huanhuan1, HUANG Xiaoyan2, Objective: To investigate the effect of atorvastatin on expression of IL-17a, LP-PLA2 in LDLR-knockout (LDLR-/-) mice. Methods: Eighteen 8-week-old male LDLR-/- mice were raised in six cages. Twelve mice were fed with high fat diet for establishing atherosclerosis model. The other six mice were fed with normal diet which was used as the normal diet control group. After eight weeks, mice fed with high fat diet were divided into high fat diet control group (n=6) and atorvastatin group (n=6, 60 mg·kg-1·d-1 per gavage). The other six mice fed with normal diet which was used as normal diet control group and continued to feed normal diet. All mice were sacrificed after eight weeks. Automatic Biochemical Analyzer was performed to measure serum lipid levels. Hematoxylin and eosin (HE) staining was used to observe the morphology of plaque. qRT-PCR was performed to analyze the level of expression of IL-17a mRNA and LP-PLA2 mRNA. Immunohistochemistry was performed to analyze the expression of protein IL-17a. Western blot was performed to analyze the expression of protein LP-PLA2. Results: Serum cholesterol (TC) and low density lipoprotein (LDL) levels were significantly higher in high fat diet control group than that in normal diet control group (both P<0.05), while there were no significantly difference of triglyceride (TG) level between two groups (P>0.05). TC and LDL levels of Atorvastatin group compared with the high fat control group were significantly reduced (P<0.05). Also, there were no significantly difference of TG level between two groups (P>0.05). Obviously, Atherosclerosis lesion area was observed in high fat diet control group, while there was no atherosclerosis lesion observed in normal diet control group. The expression of IL-17a (both protein and mRNA) and LP-PLA2 (both protein and mRNA) in high fat diet control group was significantly up-regulated than that in the normal diet control group (all P<0.05). Compared with the high fat control group, atherosclerosis lesion area of the atorvastatin group was significantly decreased, and the expression of IL-17a (both protein and mRNA) and LP-PLA2 (both protein and mRNA) was significantly lower (all P<0.05). Conclusion: Atorvastatin can contribute to anti-atherosclerosis by inhibiting the expression of IL-17a and LP-PLA2, reducing inflammation in LDLR-/-mice fed with high fat diet. 2015 Vol. 45 (5): 327- [Abstract] ( 818 ) HTML (1 KB)  PDF (9251 KB)  ( 583 ) 332 The effect of Qidong Huoxue Decoction on TLR4/NF- κB inflammatory signaling pathway in acute lung injury rats HONG Huihua1, YANG Junchao1, GAO Rundi1, ZHAO Wei1, ZHU Yuanhong1, CAI Wanru2. Objective: To investigate the protective effect of qidonghuoxue decoction (QD) on acute lung injury (ALI) in rats induced by lipopolysaccharide (LPS), and to explore the mechanism. Methods: Fifty SD rats were divided into five groups randomly: control group, model group, high-dose QD group, medium-dose QD group, low-dose QD group. The ALI model was established by intratracheal instillation of LPS. QD was administrated via esophagus to rats in QD groups; NS was substitution in control and model groups. All rats were executed 24 h after modeling, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. Results: ①HE staining showed that QD could reduce alveolar damage, pulmonary edema and inflammatory cells infiltration in rats with ALI. ②TNF-α, IL-1β, IL-10 levels were increased in rats with ALI, QD decreased the levels of TNF-α and IL-1β, increased the level of IL-10, there was significant difference between the high-dose and low-dose group (P<0.01). ③The protein and mRNA expression of TLR4/NF-κB p65 both increased in rats with ALI, while QD reduced the expression,and the effect was kind of dose-related. Conclusion: QD has a protective effect on ALI induced by LPS in rats, its mechanism is related to inhibit TLR4/NF-kB p65 signaling pathway, decrease IL-1β/TNF-α levels and increase IL-10 level. 2015 Vol. 45 (5): 332- [Abstract] ( 621 ) HTML (1 KB)  PDF (15381 KB)  ( 711 ) 338 Relationship between the methylenetetrahydrofolate reductase C677T, A1298C genetic polymorphisms and gastric cancer XU Changlong, WANG Jianzhang, ZHENG Bo, CAO Shuguang, WU Hao, XUE Zhanxiong Objective: To evaluate the association between methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C genetic polymorphisms and gastric cancer in Zhejiang Han nationality population. Methods: Select 112 cases of patients with gastric cancer, choose health check-up 218 cases as controls. The genetic polymorphisms of MTHFR (C677T and A1298C) were detected by PCR-RELP method. Results: There were no significant discrepancies of the mutational allele T and variant genotype (CT+TT) frequencies in the MTHFR C677T gene between the gastric cancer patients and the controls (34.82% vs 32.57% and 53.57% vs 52.75%, respectively, all P>0.05). The frequency of mutational allele C in MTHFR A1298C gene was significantly higher in gastric cancer patients than that in the controls (21.43% vs 12.39%, P=0.006, OR=1.929, 95%CI: 1.325~2.873). However, there were no significant discrepancies of the variant genotype frequencies (AC+CC) between the two groups (32.15% vs 36.24%, P>0.05). Conclusion: The mutational allele C in MTHFR A1298C gene may be associated with the susceptibility to gastric cancer in Zhejiang Han nationality population. 2015 Vol. 45 (5): 338- [Abstract] ( 651 ) HTML (1 KB)  PDF (6787 KB)  ( 635 ) 342 Analysis of the correlated risk factors of intrauterine adhesion ZHU Wang’ai, QU Wanglei, HAO Peipei, LV Jieqiang.? Objective: To investigate the related risk factor of intrauterine adhesion for clinical prevention of intrauterine adhesion. Methods: The clinical data of 40 patients with intrauterine adhesion and 44 without intrauterine adhesion patients were retrospectively enrolled. Unconditioned logistic analysis was used to analyze the possible risk factors with the aid of SPSS 18.0 software. Results: There were significant differences in risk factors such as the history of painless abortion, inevitable abortion between case group and control group (OR 8.172, 95%CI 2.923～22.845; OR 0.047, 95%CI 1.031～111.004). Conclusion: The primary risk factor for intrauterine adhesion is endometrial lesion assiociated with pregnancy termination. The history of painless abortion, is the main risk factors of intrauterine adhesion. 2015 Vol. 45 (5): 342- [Abstract] ( 614 ) HTML (1 KB)  PDF (3422 KB)  ( 836 ) 346 The analysis of biological characristics of CD82 mediated human thyroid carcinoma FTC-133 cells  CHEN Zhouxun1, ZHOU Hongzhong1, Henning Dralle2, Cuong Hoang-Vu2. Objective: To study the role of tumor suppressor gene CD82 in the regulation of thyroid carcinoma cell invasion/migration and its related molecular mechanisms. Methods: By using genetic engineering technology, the plasmid pCDNA3.1, which reconsturcted with the full length CD82 gene, was transfected into the thyroid carcinoma FTC-133 cells. By MTT and Transwell Assays, the proliferation rate and migration ability of these high expressed CD82 FTC-133 cells were compared with the wild-type cells FTC-133 cells. Results: 24, 48, 72 hours after transfection, the transfected cells showed reduced proliferation rate (P>0.05) and significant lower migration ability (P<0.05) in comparison with the wild-type cells and mock cells (trasfected with empty plasmid). Conclusion: These results illustrate that CD82 can reduce FTC-133 cell proliferation and invasiveness, CD82 is closely related to development and progression of thyroid carcinoma. 2015 Vol. 45 (5): 346- [Abstract] ( 618 ) HTML (1 KB)  PDF (14682 KB)  ( 663 ) 350 Application of 3D-pcASL magnetic resonance imaging in the diagnosis of acute cerebral apoplexy MAO Chuanwan, FU Yuchuan, MAO Yiting, HUANG Jianhe, LIN Xubo, SHI Jianjing, ZHOU Yunxin, WU Aiqin. Objective: To assess the applied value of the three-dimensional pseudo-continuous arterial spin labeling (3D-pcASL) technique in MRI Perfusion-weighted imaging in acute ischemic stroke. Methods: DWI and 3D-pcASL technique were be performed in thirty-nine patients suspected ischemic stroke and the onset time for 7 days. The findings of the lesions in acute cerebral infarction patients on 3D-ASL images and conventional DW images were observed. Then, the CBF values of the lesions and the contralateral symmetrical brain regions were measured. Results: Among the 39 cases, 34 cases were diagnosed as cerebral infarction during follow-up, 5 cases with TIA. In the 21 of 34 patients with cerebral infarction, the lesions were located at the gray matter, and showed low perfusion on 3D-pcASL images. The mean CBF values of these lesions were 16.7±12.2 mL·min-1· 100 g-1, and were lower than that at the contralateral area 44.8±13.9 mL·min-1·100 g-1 (P<0.01); In the other 13 cases, the lesions only involved in the white matter, the CBF values of these lesions weren’t measured for their poor differentiation with the white matter on 3D-pcASL images, in the 5 TIA patients, the lesions of 3 cases showed low perfusion on the 3D-ASL images. The mean CBF values of the affected regions were 37.6±4.4 mL·min-1·100 g-1, 58.8±10.6 mL·min-1·100 g-1 in the contralateral areas. In 34 cases of cerebral infarction patients, the lesions in DWI all showed high signal. However, the lesions were detected only in 21 cases on the 3D-ASL images, the area of the lesions on 3D-pcASL images was larger than that on the DWI in 17 of 21 patients. The singal was normal on DWI in the 5 TIA patients. Conclusion: The 3D-pcASL technique can provide localization, qualitative and quantitative diagnosis in ischemic stroke patients with the lesions located at gray matter. It can also discover that the TIA patients show normal on DWI. However, this technique has some limitations in the detection of ischemic lesions in the white matter. 2015 Vol. 45 (5): 350- [Abstract] ( 825 ) HTML (1 KB)  PDF (7701 KB)  ( 675 ) 354 The comparative study of 18F-FDG PET/CT and mathematical prediction model in diagnosis of solitary pulmonary nodule LIN Jie, TANG Kun, YIN Weiwei, ZHENG Xiangwu, CHEN Yangzong, LIN Xinshi, DAI Yunfei. Objective: To compare and analyze the value of 18F-FDG PET/CT and the mathematical prediction model in diagnosis of solitary pulmonary nodule (SPN), using receiver operating characteristic (ROC) curves analysis. Methods: All of 186 patients confirmed with SPN and performed with PET/CT were retrospectively analyzed in this study. For PET/CT integrated images, the morphology and metabolism of lesions were semiquantitatively or visual analysed by observers. A 5-score system was used to classify the diagnostic results of PET/CT integrated images: 0, definitely benign; 1, benign more likely; 2, probably benign; 3, probably malignant; 4, malignant more likely; and 5, definitely malignant. The logistic mathematical model was established with univariate analysis and multivariate analysis. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT and the mathematical model in diagnosis of SPN were calculated respectively. The difference of the areas under the ROC curves (AUC) between PET/CT and the mathematical model was compared. Results: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 97.6%, 79.4%, 91.4%, 90.2% and 94.3%, respectively. The mathematical model established by logistic regression analysis was: p=ex/(1+ex), x=-8.111+0.091×age+1.351×lobulation+3.565×vascular convergence+2.153×retraction of pleural+0.447×SUVmax. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the model for prediction of SPN were 87.8%, 81.0%, 85.5%, 90.0% and 77.3% respectively. The AUCs of PET/CT and mathematical model were 0.951±0.015 and 0.927±0.019. There was no statistically significant in difference of AUC between PET/CT and mathematical model (P>0.05). Conclusion: The value of mathematical prediction model in diagnosis of SPN is similar to PET/CT and not affected by subjective factors. Therefore, it should be used in clinical practice combined with PET/CT for improving diagnostic accuracy. 2015 Vol. 45 (5): 354- [Abstract] ( 631 ) HTML (1 KB)  PDF (5797 KB)  ( 682 ) 359 The optimal treatment duration of mometasone furoate nasal spray in the treatment of chronic rhinosinusitis in children QIAN Xubo1, NI Liyan2, XU Chengbo3, YE Xiaohong1, WANG Zhijiang4. Objective: To define the optimal treatment duration of mometasone furoate nasal spray (MFNS) in children with chronic rhinosinusitis (CRS). Methods: We did a randomized and controlled study of 267 children with CRS from three hospitals in Jinhua between September, 2013 and August, 2014. Of these patients aged from 3.0 to 16.3 years, 86 patients were randomly assigned to group one, 88 to group two, and 93 to control group. Group one received MFNS for 6 weeks, group two for 8 weeks, and control group for 12 weeks, respectively. All groups received mucolytics for 6 weeks and antimicrobial agents for 10-14 days at the beginning of the treatment. Results: The incidences of posterior nasal drip, cough, anterior nasal drip, nasal blockage, and hawk were 67.00%, 65.90%, 40.80%, 35.20%, and 6.40%, respectively. There were no significant differences in disappearance times of these clinical manifestations among the three groups (P>0.05). At the end of the treatment, Lund-Mackay score in group one was significantly higher than those of group two and control group (P<0.017); but no difference was observed between group two and control group (P>0.017). Conclusion: The optimal duration of MFNS treatment in children with CRS is 8 weeks. 2015 Vol. 45 (5): 359- [Abstract] ( 716 ) HTML (1 KB)  PDF (5350 KB)  ( 705 ) 364 Clinicopathological features of solid papillary carcinoma of the breast LUO Huarong, XU Cheng, ZHENG Haihong, WENG Shouxiang, GAN Meifu.? Objective: To investigate the clinicopathological features of solid papillary carcinoma (SPC) of the breast. Methods: A study was performed to analyse the clinical and pathological manifestations in 18 cases of SPC. Immunohistochemical staining for ER, PR, CerbB-2, Ki-67, CK5/6, CK14, P63, Syn and CgA was performed. And the expression of HER-2 gene amplification was detected by fluorescence in situ hybridization. Results: All the tumors presented as a palpable, centrally located mass or as bloody nipple discharge. Histologically, the tumor was comprised of multiple circumscribed expansile nodules with delicate fibrovascular cores. 55.6% of these tumors had extracellular or intracellular mucin and 16.7% was associated with invasive carcinoma. Immunohistochemically, all tumor cells were strongly positive for ER and PR. CerbB-2 was negative in the most cases except for 4 cases with weak expression. All cases were negative for CK5/6, CK14 and P63 in the cellular nodules. Peripheral myoepithelium was complete in 9 cases, discontinued in 5 cases and loss in 4 cases. The positive expression rates of Syn and CgA were 72.2% and 55.6%, respectively. The average positive rate of Ki-67 in tumor cells was 8.5%. None of 3 cases with invasion had HER-2 gene amplification. One of 17 cases with axillary lymph node dissection or sentinel lymph node biopsy had axillary lymph node metastasis at operative time. And none of 17 patients (94.4%) followed up had tumor recurrence and metastasis. Conclusion: SPC is a rare breast cancer, predominantly found in elderly females, with distinctive histological morphology and immunophenotype. Clinicopathological features and follow-up data suggest that SPC often carries an indolent clinical behavior and favorable prognosis. 2015 Vol. 45 (5): 364- [Abstract] ( 626 ) HTML (1 KB)  PDF (16338 KB)  ( 655 ) 369 A comparison of clinical features between hyperlipidemic acute pancreatitis and acute biliary pancreatitis FU Beibei, WU Jinming, XU Mei, ZHAO Zhoujing, JIN Jianwei.? Objective: To compare the differences of clinical features between hyperlipidemic acute pancreatitis (HLAP) and acute biliary pancreatitis (ABP). Methods: A total of 20 HLAP patients and 20 ABP patients were enrolled in the study, then the clinical characteristics, serum biochemicals, the score of AP, the ratio of severe cases, imaging findings were analyzed contrastively and retrospectively. Results: In HLAP group, more were complicated with fatty liver and recurrence rate was much higher, the mean age was lower compared to ABP group (P<0.01). The TC, TG, FBG were higher in the HLAP group (P<0.05), while the AMY, ALT, AST, ALP, TBIL, DBIL, serum calcium and leukocytes number were significant lower in the HLAP group (P<0.05). The proportion of MCTSI score≥4, Ranson score≥3 and the ratio of severe cases were higher in patients with HLAP than that in patient with ABP (P<0.05). There were differences in the change of perirenal space and involved parts between the two groups. Conclusion: The significant differences are existed in HLAP and ABP in clinical characteristics, serum biochemicals, the ratio of severe cases and imaging findings. 2015 Vol. 45 (5): 369- [Abstract] ( 586 ) HTML (1 KB)  PDF (4199 KB)  ( 608 ) 372 Clinical analysis on risk factors of the colostomy hernia after rectal cancer Miles operations  ZHU Deyi1, WANG Ting2, ZUO Wei3.?  Objective: To research the risk factors related to colostomy hernia’s occurrence after rectal cancer Miles operations and provide a basis for the prevention of occurrence of postoperative colostomy hernia. Methods: Retrospective analysis of the clinical data of the 118 patients who received rectal cancer Miles operations in our hospital from March 2005 to March 2008. The 15 possible influencing factors of the colostomy hernia were analyzed by single factor analysis and logistic regression analysis, then we conducted a 5 years’ follow-up. Results: Among these 15 possible related factors of colostomy hernia’s occurrence, smoking, body mass index (BMI), combined diabetes, colostomy liquefaction/infection, lower proteinemia, the selection of colostomy position, severe abdominal distention, urinary retention and severe cough were related to postoperative colostomy hernia’s occurrence (P<0.05). Logistic regression analysis showed that smoking, obesity, combined diabetes, colostomy liquefaction/infection, selection of colostomy position, severe abdominal distention and severe cough were significanly related with the colostomy hernia’s as dependent risk factors (P<0.05). Conclusion: There is a high incidence of colostomy hernia for rectal cancer Miles operation 5 years later. Smoking, BMI, combined diabetes, colostomy liquefaction/infection, selection of colostomy position, severe abdominal distention and severe cough are significantly related with the colostomy hernia’s as dependent risk factors. 2015 Vol. 45 (5): 372- [Abstract] ( 606 ) HTML (1 KB)  PDF (3597 KB)  ( 721 ) 376 The gene analysis of a Chinese pedigree with congenital blood coagulation factor XI deficiency  DAI Liya1, ZHANG Deting1, XIE Haixiao2, ZHANG Yang2, ZHENG Fangxiu2, WANG Mingshan2.? Objective: To analyze genetic mutation and explore its molecular pathogenesis for a Chinese pedigree with congenital blood coagulation factor XI deficiency. Methods: Activated partial thromboplastin time (APTT), Prothrombin time (PT), FXI activity (FXI:C), FXI antigen (FXI:Ag) and other coagulant parameters were assayed. Exons 1-15, exon-intron boundaries and 5’, 3’ untranslated sequences of FXI gene of the proband and other family members were analyzed by direct sequencing. The detected mutations were confirmed by sequencing the complementary strand. Results: The proband had prolonged APTT (50.0 s). The APTT results of her brother and son were prolonged too, which were 53.7 second and 51.8 second respectively. Other members’ APTT were in normal range. The activity and antigen of proband’s FXI was 22.5% and 29.0%, while her brother was 22.3% and 18.0%, her son was 35.5% and 29.0%, her father was 42.0% and 40% separately, which were called cross-reactivity material negative. The mother of proband had normal results above-mentioned. After the amplification and sequencing of 15 extrons in FXI, an exon 8 C16642→T mutation in proband as well as in her father, brother and son was found, which led to an amino acid change of Gln→Term at residue 263. Conclusion: The mutation of C16642→T on exon 8 is the main reason for the congenital FXI deficiency in this Chinese pedigree. 2015 Vol. 45 (5): 376- [Abstract] ( 664 ) HTML (1 KB)  PDF (5454 KB)  ( 1166 ) 380 Serological investigation of HBV, TP, HIV of Rui’an childbearing women during 2010-2012  ZHAO Min, CHEN Hong, DENG Tongyang, FENG Weiliang.? Objective: To survey the infection of HBV, TP, HIV of Rui’an childbearing women, and to provide experimental evidence for health care of women as well as prenatal and postnatal care. Methods: The infection of hepatitis B virus (HBV), treponema pallidum (TP), and HIV were detected for childbearing women who came to our hospital for premarital medical check-up from January 2010 to September 2012. Results: Among 12 578 childbearing women, 919 cases (7.31%) were HBsAg positive, 46 cases were anti-TP positive, and 3 cases (0.02%) were anti-HIV1/2 positive. Conclusion: Rui’an childbearing women have the above HBV, TP, and HIV infection, premarital medical check-up, timely prevention and effective intervention are conducive to prenatal and postnatal care. 2015 Vol. 45 (5): 380- [Abstract] ( 587 ) HTML (1 KB)  PDF (2775 KB)  ( 656 ) 383 The rehabilitative effects on stroke patients of hospital at home under remote guidance HUANG Guanfeng, ZHU Haiyong, WANG Xiaotong, HUO Xinlong. Objective: To evaluate the physical and psychological rehabilitative effects on stroke patients in hospital at home service under remote guidance. Methods: Sixty patients were randomly divided into remote guidance group (RG) or normal hospital at home group (NH). The RG patients recieved a termly remote guidance from the physicians after discharge, including medical care, rehabilitation training and psychological counseling. The physical and psychological rehabilitative effects were evaluated by MBI (modified barther index), FMI (fugl-meyer assessment scale), BBA (berg balance scale), HAMA (hamilton anxiety scale) and HAMD (hamilton depression scale) scales after 6 months therapy, and by satisfaction survey after 14 days. Results: The RG group manifested better results of the MBI, FMI, BBA, HAMA and HAMD scales results (P<0.05). Patients in NH group reflected dissatisfaction of night care and information acquisition, they feel more insecurity at night (P<0.05). Conculsion: Hospital at home service under remote guidance has better effect in physical and mental rehabilitation on the stroke patients. New network technology as a medical aid guide is worth popularizing. 2015 Vol. 45 (5): 383- [Abstract] ( 811 ) HTML (1 KB)  PDF (5024 KB)  ( 681 )

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