Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles Current Issue Archive Advanced Search Read Articles Download Articles Email Alert

2014 Vol. 44, No. 10 Published: 2014-10-25   703 Primary research of the relationship between HCMV infection and gastric cancer JIN Jinji1, TU Jianxin2, WU Ming3, MA Haiguang1, SHEN Xian1, XUE Xiangyang4. Objective: To explore the correlation between HCMV infection and gastric cancer. Methods: The specific IgG and IgM antibodies of HCMV in serum of gastric cancer group (n=80) and health control group (n=80) were detected using the chemiluminesence immunoassay. HCMV infection in gastric cancer tissues and corresponding normal tissues were determined through the detection of UL55 gene by Nested PCR. The relationships between HCMV infection and clinical features of gastric cancer were further analyzed. Results: The positive rate of HCMV-IgG and IgM were 95% (76/80) and 6.25% (5/80) in gastric cancer group, respectively. Meanwhile, the positive rate were 97.5% (78/80) and 3.75% (3/80) in health control. There was no statistically significant difference between the gastric cancer and health control group in HCMV-IgG, IgM detection. However, there was a significant difference between gastric cancer tissues and corresponding normal tissues in HCMV detection. The positive rate of HCMV UL55 was 50% (11/22) in gastric cancer tissue samples, whereas 9.09% (2/22) in corresponding normal tissues through Nested PCR detection. In addition, There was no obvious association between HCMV infection and TMN stage, pathological differentiation type and the size of tumor. Conclusion: It is the first time to report the HCMV infection in gastric cancer tissues, and the HCMV may preferentially infect the neoplastic epithelium than corresponding normal epithelium, this research suggests the HCMV infection may participate in the occurrence and development stages of gastric cancer. 2014 Vol. 44 (10): 703-707 [Abstract] ( 793 ) HTML (1 KB)  PDF  (0 KB)  ( 393 ) 708 Protective effects of paeonol on cognitive dysfunctions in mice with vascular cognitive impairment WANG Hao1, GENG Zhaoming2, GUO Dengjun1, HU Zhiwei1, WANG Baichen1. Objective: To investigate the effects of paeonol on cognitive dysfunctions and hippocampal neuronal injury of vascular cognitive impairment (VCI) mice. Methods: Sixty C57BL/6 mice were randomly divided into sham opertated group, the VCI group and the paeonol treated groups (low, medium and high dose). The VCI models were dupilicated by the bilateral common carotid artery occlusion (2VO). The cognitive impairments were observed by Morris water maze. The contents of MDA, SOD and NO in hippocampus were determined spectrometrically. The hippocampal neuron injuries in the CA1 region were detected by nissle staining. Results: VCI induced the decreased cognitive function and neuron injury in the hippocampal CA1 region (P<0.01). And MDA and NO contents were significantly increased, whereas SOD activity was dramatically decreased after VCI (P<0.01). Compared with VCI model goup, the medium and high dose of paeonol treatment significantly improved cognitive impairments and reduced pathological changes in hippocampal CA1 region (P<0.05, P<0.01). In additon, the medium and high dose of paeonol treatment markedly improved SOD activity, decreased MDA and NO contents in hippocampus (P<0.05, P<0.01). Conclusion: Paeonol can improve cognitive impairments and neuronal injury in VCI mice, which may be related to the increased antioxidative ability of brain tissue. 2014 Vol. 44 (10): 708-711 [Abstract] ( 616 ) HTML (1 KB)  PDF  (0 KB)  ( 492 ) 712 The three-dimensional characteristic of mandibular growth in children with mixed dentition PAN Sisi1, WANG Xin2, DAI Weiwei1, WANG Jianfeng1, CHEN Wenjing3, HU Rongdang1. Objective: To analyze the three-dimensional characteristics of mandibular growth of the children with mixed dentition by Cone Beam Computed Tomography and discuss the whole trend of mandibular growth. Methods: Cone Beam Computed Tomography scans were performed in 140 subjects from 6 to 12 years old with mixed dentition. CT images were constructed into 3D model using medical image processing software Dolphin Imaging 11.0. Fifteen linear and six angular measurements including mandibular length, mandibular width, etc, were positioned through MPR method and analyzed by SPSS 17.0. Results: Transverse comparison in 6~8 years old for early age group of 60 cases with 9~12 years old for late age group of 80 cases, the measured values were significantly increased in the late age group, including the left mandibular length [(7.29±0.7) mm], the right mandibular length [(8.00±0.9) mm], the condyle spacing [(3.29±0.8) mm], coronoid spacing [(4.76±0.7) mm], sigmoid notch spacing [(5.11±0.6) mm], mandibular angle spacing [(4.83±0.7) mm], mental foramen spacing [(1.65±0.4) mm], mental foramen mesial buccal point spacing [(1.16±0.4) mm], mental foramen distal buccal point spacing [(2.39±0.4) mm], mental foramen distal tongue point spacing [(1.42±0.6) mm], the left corpus length [(5.80±0.8) mm], the right corpus length [(6.95±0.7) mm], the left ramus height [(4.40±0.5) mm], the right ramus height [(4.33±0.6) mm], left mandibular angle [(3.75±0.4) º], right mandibular angle [(5.18±0.3) º], condylar strength [(0.62±0.28) º], coracoid strength [(0.68±0.3) º] and sigmoid notch strength [(0.59±0.27) º] significantly (P<0.05). The inner side of mental foramen mesial almost unchanged and mandibular angle strength increased [(0.32±0.4) º], both had no significant difference (P>0.05). Conclusion: Mandibular dimensions are increased in the late age group (except mental foramen mesial tongue point width), the increase in different parts of mandibular are different. The change of mandibular width from the former show a trend of increase, mandibular width of mental foramen area in nearly increase is mainly caused by bone hyperplasia in the outside of mandibular. The trend of mandibular growth is downward, forward and outward. 2014 Vol. 44 (10): 712-717 [Abstract] ( 646 ) HTML (1 KB)  PDF  (0 KB)  ( 366 ) 718 An application of low tube voltage in combination with simultaneous iterative reconstruction technique in cerebrovascular CT imaging CAO Guoquan, TANG Kun, PAN Kehua, TAI Yunpeng, CHEN Xiao, WU Enfu, WANG Zhenzhang. Objective: To study the impacts of tube voltage and simultaneous iterative reconstruction technique on the image quality and radiation dose in cerebrovascular imaging and determine the optimum tube voltage and iterative reconstruction parameters. Methods: A home-made blood vessel of brain was constructed using an ATOM 701-D adult male phantom head and iodine-water mixture contrast agent. A 320-row volume CT was used to scan the home-made brain at tube voltages of 80, 100 and 120 kV in combination with off, mild, standard and strong iterative reconstruction levels (12 protocols in total), respectively. Tube current and other parameters were not changed during scanning. CT value of the transverse blood vessels and its corresponding noise, CT value of brain tissue around blood vessels and its corresponding noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were obtained. One-Way ANOVA analysis was applied to investigate the impacts of different tube voltages and simultaneous iterative reconstruction levels to image quality. Results: Compared with group 120 kV, the CTDIvol, dose length product (DLP), effective dose (ED) of group 100 kV and 80 kV reduced 39.29%, 39.52%, 39.42% and 66.88%, 67.02%, 67.31% respectively. When the tube voltage was kept constant, blood vessel noise, noise of brain surrounding blood vessels, SNR and CNR showed statistical difference (P<0.05), while CT values of blood vessel and brain tissue around blood vessels had no statistical difference (P>0.05) at different iterative reconstruction levels. When iterative reconstruction level was not changed and tube voltage was varied, both CT values of blood vessel and blood vessel noise exhibited statistical difference (P<0.05), CT values of brain tissue around blood vessels, SNR and CNR had no statistical difference (P>0.05), and noise of brain tissue around blood vessels showed statistical difference (P<0.05) at AIDR 3D off and mild levels and no statistical difference (P>0.05) at standard or strong levels. Conclusion: High-quality cerebrovascular imaging can be acquired at a tube voltage of 100 kV in combination with a standard or strong level of iterative reconstruction algorithm. 2014 Vol. 44 (10): 718-722 [Abstract] ( 616 ) HTML (1 KB)  PDF  (0 KB)  ( 385 ) 723 Influence of fasudil on the proliferation and fibrosis of renal tubular epithelial cells incubated with high glucose GU Lingjia1, NI Liansong2. Objective: To investigate the influence of fasudil on the proliferation and fibrosis of human renal tubular epithelial cells incubated with high glucose. Methods: HK-2 cells were divided into normal control group (D-glucose 5.5 mmol/L), high tension group (D-glucose 5.5 mmol/L+54.5 mmol/L mannitol), high glucose group (D-glucose 60 mmol/L), high glucose+fasudil treatment group (the concentrations of fasudil were 5, 10 and 20 μmol/L). Cell proliferation was assessed with MTT assay. Changes in the p-MYPT1-Thr853 were detected with co-immunoprecipitation assay. The expression of connective tissue growth factor (CTGF) was detected with western blot, the protein content of transforming growth factor-β1 (TGF-β1) and fibronectin (Fn) in the supernatant were detected by ELISA. Results: Compared with normal control group, cell proliferation and the expression of p-MYPT1-Thr853, TGF-β1, CTGF and Fn were significantly increased in high glucose group. Compared with high glucose group, cell proliferation and the expression of p-MYPT1-Thr853, TGF-β1, CTGF and Fn were significantly decreased in fasudil treatment group. Conclusion: Fasudil can inhibit high glucose-induced proliferation and fibrosis of HK-2 and it may produce effect through the inhibition of Rho kinase activity. 2014 Vol. 44 (10): 723- [Abstract] ( 567 ) HTML (1 KB)  PDF  (0 KB)  ( 346 ) 727 Correlative analysis between carotld arteriosclerosis early identification and cardio-ankle vascular index, age and their interaction HUANG Xi1, LI Ping1, ZHANG Qin1, ZHUGE Zhangming1, HU Huaqing2, CUI Huan3, RUAN Jichen1, MAO Guangyun4. Objective: To explore the correlation between arteriosclerosis early identification and cardio-ankle vascular index (CAVI), age and their interaction. Methods: A cross-sectional study was conducted to explore this association in a Chinese population consisting of 328 participants enrolled from the ordinary medical checkup population in the 1st affiliated hospital of Anhui Medical University. CAVI was measured in duplicate and carotid ultrasound detection was performed in a quiet environment by well-trained physicians. Generalized linear models were conducted to assess the correlation. Results: Prevalence of carotid arteriosclerosis for participants with high, medium and low CAVI score were 90.9%, 57.0% and 19.8%, respectively. After adjusted for the potential confounding factors such as age, gender, body mass index (BMI), low density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), blood pressure (BP), creatinine, education, occupation, psychological tension, cigarette smoking and alcohol drinking, CAVI positively associated with the risk for carotid arteriosclerosis. Compared with participants in the lowest tertile of CAVI (5.15~7.40), those in the medium (7.41~8.65) and highest (8.66~13.60) had the OR (95% CI) of 2.2 (1.0, 4.9) and 4.4 (1.5, 13.3) for developing carotid arteriosclerosis (P=0.007). Compared with low age groups, the risks of future carotid arteriosclerosis for participants with medium and high age increased 7.1 and 51.3 folds, respectively. CAVI and age were all positively associated with the future carotid arteriosclerosis risk (Trend test P<0.001). Compared to subjects with low age and low CAVI, the risks of future carotid arteriosclerosis for participants with low age and high CAVI, high age and low CAVI, high age and high CAVI increased 6.6, 17.3 and 57.1 folds, respectively. Conclusion: CAVI is an independent risk factor of carotid arteriosclerosis, can be used for the prediction of future carotid arteriosclerosis developing and has a statistical significantly interaction with age in predicting the future risk of carotid arteriosclerosis. 2014 Vol. 44 (10): 727-732 [Abstract] ( 557 ) HTML (1 KB)  PDF  (0 KB)  ( 360 ) 733 The relationship between the CYP3A5 genetic polymorphisms and susceptibility to childhood acute leukemia HUANG Zhen, CHEN Min, ZENG Weiwei, LI Yuan. Objective: To study the relationship of CYP3A5-6986A/G polymorphism and acute leukemia in Han population of southern Chinese. Methods: The methods of polymerase chain reaction-restriction fragment length polymorphism and PCR sequence were used, the polymorphism of the CYP3A5 gene was detected in both 119 acute leukemia patients and 106 control subjects. Results: ①The differences in the distribution of genotype of CYP3A5-6986A/G between the patients and the controls were significant. ②The genetic frequency of G allele in ALL and in AML were all higher than that in controls. ③The results by gender stratification showed that the boy individuals with CYP3A5 variant genotype were more susceptible to childhood leukemia with a 2.65-fold increased risk compared to the individuals with wild genotype. ④There was no variation of CYP3A5-6986A/G polymorphism on acute leukemia patients between Wenzhou and Suzhou area. Conclusion: The CYP3A5 genetic polymorphism may be associated with the susceptibility of acute leukemia in Han population of male southern Chinese. 2014 Vol. 44 (10): 733-736 [Abstract] ( 731 ) HTML (1 KB)  PDF  (0 KB)  ( 566 ) 737 Obserration on the effect of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis XUAN Xuan, WU Lingjian, LI Bingxu Objective: To evaluate the clinical efficacy and safety of narrow-band ultraviolet b combined with desloratadine in the treatment of generalized eczema and dermatitis. Methods: Non-randomized concurrent control trial was used to assign 114 patients in UV-treatment group (n=57) and glucocorticoid-treatment group (n=57). Patients in UV-treatment group received the therapy of narrow-band ultraviolet b combined with oral desloratadine. Patients in glucocorticoid-treatment group were topically applied with mometasone furoate ointment combined with oral desloratadine. In UV-treatment group, symptom/sign scores were evaluated at the 2th, 4th and 8th week’s end of the treatment. In glucocorticoid-treatment group, symptom/sign scores were evaluated at the 2th and 4th week’s end of the treatment. Scores and effective rates were observed after the treatment. Results: After 2 weeks of treatment, the median score of glucocorticoid-treatment group (3) and UV-treatment group (2) had significant difference (P<0.05); the efficient rate of UV-treatment group (12.3%) and hormones-treatment group (38.6%) had significant difference (P<0.05). After 4 weeks of treatment, the median score of glucocorticoid-treatment group (5) and UV-treatment group (4) had no significant difference (P>0.05); the efficient rate of UV-treatment group (59.6%) and glucocorticoid-treatment group (56.1%) had no significant difference (P>0.05). In UV-treatment group, the median score had significant difference at the 2th (2), 4th (4) and 8th (6) week’s end of the treatment; the efficient rate had significant difference at the 2th (12.3%), 4th (59.6%) and 8th (84.2%) week’s end of the treatment. Conclusion: The therapy of narrow-band ultraviolet b is safe and effective in the treatment of patients with generalized eczema and dermatitis. 2014 Vol. 44 (10): 737-739 [Abstract] ( 768 ) HTML (1 KB)  PDF  (0 KB)  ( 504 ) 740 Effect of home rehabilitation nursing intervention on quality of life and function of patients after total hip replacement surgery ZHENG Wenxian, YANG Jinji, ZHENG Zhangqiong, LIN Lingling, TU Wenzhan, FU Liyan. Objective: To probe the effect of home rehabilitation nursing replacement intervention on quality of life and function of patients after total hip surgery. Methods: One hundred patients with total hip replacement were individed two groups, one group received home rehabilitation nursing intervention, the other group did not, The SF-36 and Harris scores of patients were evaluated when the patients after discharge one and three months. Results: The observation group had high score,were obviously higher than those of the control group patients after discharge one and three months. Conclusion: The home rehabilitation nursing intervention can improve quality of life and function of patients after total hip replacement surgery. 2014 Vol. 44 (10): 740- [Abstract] ( 683 ) HTML (1 KB)  PDF  (0 KB)  ( 535 ) 743 The expression and clinical significance of WT1 in endometrial carcinoma JIN Weiwei1, CAI Pingsheng1, ZHAO Xiaoying1, ZHENG Feiyun2. Objective: To detect the protein and gene expression of WT1 in different types of tissues, including endometrial adenocarcinoma (EA) tissues, endometrial hyperplasia tissues and normal tissues and correlated the expression with the clinicopathological features. Methods: The relative expression WT1 mRNA was detected by real-time quantitative PCR. The expression of WT1 protein was detected by Western blot in different types of endometrial tissues. Results: The expression of WT1 mRNA and protein in endometrial adenocarcinoma tissue was significantly higher than that in endometrial hyperplasia tissues and normal endometrial tissue respectively (P<0.01). There was no significant difference among age, menopause status, clinical stage, lymph node metastasis status, ER, BMI except histological stage, myometrial invasion and PR status concerned to WT1 gene expression (P<0.05). There were no significant correlations among the protein expressionof WT1 and age, menopause status, clinical stage, myometrial invasion ER, PR, BMI (P>0.05), but related to histological stage and lymph node status, significantly (P<0.05). Conclusion: Up-regulation of WT1 protein and gene expression are correlated to the oncogenesis and progression of EA. 2014 Vol. 44 (10): 743-747 [Abstract] ( 697 ) HTML (1 KB)  PDF  (0 KB)  ( 503 ) 748 Application of therapeutic drug monitoring of vancomycin in ICU patients JIN Hui1, ZHOU Ziye1, ZHANG Xiuhua1, HU Guoxin2 Objective: To establish a HPLC method for fast determination of vancomycin in serum and using the method for monitoring ICU patients’ therapeutic drug concentration. Methods: HPLC analysis was performed using a Water’ Xbridge column (4.6 mm×150 mm, 5 µm). The mobile phase was KH2PO4 (25 mmol• L-1)-methanol (86:14, pH=2.4). The flow-rate was 1.0 mL•min-1 and the detection wave length was 236 nm by UV. The injection volume was 20 µL and the temperature of column was 40 ℃. Results: The concentration range of vancomycin was 1~100 mg•L-1 while the calibration curve showed good linearity (r=0.9992), and the minimum limit of quantitation was 1.0 mg•L-1. The relative standard deviations (RSD) of intra-day and inter-day were 5.83% and 6.06%, the extraction recovery was 79.71%. Twelve patients first blood valley concentration of vancomycin was between 10 and 20 mg•L-1. There were 17 cases of the treatment for effective, total effective rate was 60.71%. Conclusion: The method is simple, sensitive, exact, rapid and good repeatability. It can be used for detecting the concentration of vancomycin in ICU patients. There is bigger individual difference in blood concentration after giving Vancomycin. Clinical need monitoring results formulate reasonable individualized dosage regimen for ICU patients. 2014 Vol. 44 (10): 748-751 [Abstract] ( 727 ) HTML (1 KB)  PDF  (0 KB)  ( 523 ) 752 Analysis of clinical features and surgery treatment of 7 cases of primary liver sarcomatoid carcinoma RUAN Xiaojiao, JI Ling, ZHU Hengliang, ZHENG Xiaofeng, JIANG Feizhao. Objective: To explore the clinical and pathological features of primary liver sarcomatoid carcinoma and to discuss its diagnosis, the operative method and prognosis. Methods: The clinical data of 7 patients with pathologically proven sarcomatoid carcinoma of the liver were retrospectively reviewed in our hospital from February 2004. Results: Three cases showed right upper abdomen pain, abdomen distension in 1 case, 1 case of anorexia and fatigue, 2 cases were asymptomatic. The CT appearances of sarcomatoid carcinoma had both characteristics of hepatic cancer and carcinoma CT signs could show malignant characlteristics of lesion.Varied degrees of contrast enhancement could be visualized. All the patients were undergone surgery. The tumor was composition with cancer and sarcoma-like areas, and the tumor cells of sarcomatoid areas were very complex.Immunohistochemical positive for CK (7), EMA (5), MSA (1), CK7 (2), HepPar-1 (3) and Vimentin (6), DES (1). The length of follow-up ranged from 17 days to 35 months during which time 2 patients with disease free, 2 survived as tumer carriers and 3 patients died. Conclusion: Liver sarcomatoid carcinoma is a kind of extremely rare malignant tumor, with untypical clinical symptoms, non-specific imaging feature, tumor cells with complex and diverse pathological features, diagnosed according to immunohistochemistry. Surgical resection is the main treatment, insensitive to radiotherapy and chemotherapy,with worse prognosis. 2014 Vol. 44 (10): 752-755 [Abstract] ( 724 ) HTML (1 KB)  PDF  (0 KB)  ( 343 ) 756 Clinical research of combination of memantine and butylphthaliden in the treatment of patinta with vascular dementia PAN Rongrong1,2, ZHOU Longshou2, ZHU Wenzong2, HE Jincai3. Objective: To observe the curative effect and safety of combination of memantine and butylphthalide in the treatment of vascular dementia (VaD), the improvement of the cognitive function and behavioral capacity. Methods: Forty cases with VaD were randomly divided into 2 groups: one group treated with memantine and butylphthalide, the other group treated with memantine. MMSE scale and ADL scale of 2 groups were assessed and compared the pre-treatment with the treatment in 3 months, 6 months later. A comparative study was made to evalate the curative effects and side effects between 2 groups. Results: After treating with memantine and butylphthaliden for 3 months and 6 months, the ADL scores were (25.2±5.4) and (23.2±5.6) respectively, MMSE scores were (18.8±4.4) and (20.1±4.8) respectively. After treatment with memantine for 3 months and 6 months, the ADL scores were (26.6±5.9) and (25.4±6.1) respectively, MMSE scores were (18.1±4.9) and (18.9±4.7) respectively. The data compared pre-treatment with the two groups had statistical significance (P<0.05). The scores of MMSE and ADL after 6 months treatment between two groups have statistical significance (P<0.05). No serious adverse events was recorded during treatment. Conclusion: Combination of memantine and butylphthalide can markedly ameliorate the cognitive function and behavioral abilities in patients with vascular dementia. Its combination with butylphthalide is superior to its single use with high safety. 2014 Vol. 44 (10): 756-758 [Abstract] ( 800 ) HTML (1 KB)  PDF  (0 KB)  ( 524 ) 759 Imaging diagnosis of eosinophilic granuloma of skull in children YE Shengli1, LIN Xiaohe1, LUO Lili1, XU Sien1, HE Jiawei2. Objective: To investigate the image manifestation and improve the ability of diagnosis of skull eosinophilic granuloma in chidlren. Methods: Imaging data of skull eosinoplilic granuloma in children-retrospective analysis of 20 cases by X-ray, CT and MRI scan, included: 2 cases of X-ray, 20 cases of CT scan, 4 cases of MRI scan (including 2 cases of enhancement scanning). Results: Out of 20 cases, single lesion was found in 16 cases, and multiple lesions were found in 4 cases. There were totally 26 lesions in all 20 patients, temporal bone (n=13), frontal bone (n=7), occipital bone (n=4), parietal bone (n=2) were respectively being involved. The X-ray findings of 2 cases were clear, sharp edge of the circular hole shaped bone destruction. The CT scanning found 26 lesions, including 7 cases of osteolytic destruction, 19 cases of punched-out like bone defect, 21 cases of soft tissue mass. The MRI scanning revealed 4 cases of soft tissue mass adjacent to the osteodestructions. Compared with gray matter of the brain, MR showed isosignal intensity on T1WI and T2WI after intravenous injection of Gd-DTPA, the lesions showed enhanced remarkably. Conclusion: The CT and MR manifestations of children skull EG have certain characteristics. Combination of medical record may improve the diagnostic accuracy in the majority of cases. The MRI can accurately show the location, shape and extent of skull eosinophilic granuloma in children which is valuable in differential diagnosis of various causes. 2014 Vol. 44 (10): 759-761 [Abstract] ( 1026 ) HTML (1 KB)  PDF  (0 KB)  ( 344 ) 762 Diagnosis and treatment of ovarian Brenner tumor: an analysis of 29 cases HAN Lingzhi, HUANG Qiusui, ZHAO Yu, WANG Lianyun, DUAN Ping. Objective: To explore the diagnosis and treatment of ovarian Brenner tumor. Methods: The clinical data of 29 patients diagnosed as ovarian Brenner tumors were collected to retrospective analysis. The patients were treated in Gynecology department of the Second Affiliated Hospital of Wenzhou Medical University from January 2001 to December 2013, and the follow-up visit data was surveyed. The results we collected about the characteristics of diagnosis and treatment of ovarian Brenner tumor were summarized and analyzed. Results: In our 29 cases, most of patients were asymptomatic in the preoperative period. Nineteen cases showed an incidentally asymptomatic adnexal mass in the annual gynecological ultrasound exam. It was confirmed that, 2 cases and 1 case of patients were benign, borderline malignant tumor respectively by surgery in 26 cases. The tumor was unilateral in 20 cases and bilateral in 9 cases. Fourteen cases were pure Brenner tumors and 15 cases were mixed tumors consisting of a Brenner tumor element and other ovarian tumor or uterine neoplasms. In these cases, 5 cases performed an operation of tumor resection, 10 cases of unilateral salpingo-oophorectomy, 8 cases of bilateral adnexactomy, 5 cases of whole uterus double appendix resection, 1 case of radical hysterectomy ,bilateral salphing-oopherectomy and pelvic and para-aortic lymphadenectomy. During follow-up visits for 2 years, one recurrence occurred in tumor resection, 2 cases of patients died of other reasons, and 6 cases with malignant tumor have been alive after chemotherapy postoperatively up to now, excepted the losted one. Conclusion: Our results indicate that most of ovarian Brenner tumor will be benign with its clinical manifestations, relevant examination and treatment have less differences with other ovarian epithelial tumor. Currently, the diagnosis of Brenner tumor is confirmed clinically by postoperative pathology return, and the surgical treatment is effective. 2014 Vol. 44 (10): 762-765 [Abstract] ( 698 ) HTML (1 KB)  PDF  (0 KB)  ( 424 ) 765 Clinical observation of singulair combined with clarityne treatment of children with cough variant asthma WANG Hong1, SHI Yicheng1, LU Qinhong2. Objective: To evaluate clinical efficacy of singulair combined with loratadine in the treatment of children with cough variant asthma (CVA) to provide the basis for the treatment of cough variant asthma. Methods: Sixty cases of CVA were randomly divided into control group and observation group, the control group with conventional therapy and inhaled corticosteroids, the observation group was treated with singulair combined with loratadine treatment, the clinical efficacy and adverse reaction of two groups were compared. Results: The total effective rate of observation group was 86.7%, significantly higher than that in control group 50%, P<0.05; two groups of children with eosinophil counts were significantly decreased, P<0.05; after treatment, the observation group was significantly lower than the control group, there was a statistically significant difference between groups (P<0.05); the observation group after treatment, cough relieving and the disappearance time were shorter than that in the control group, there was a statistically significant difference between groups (P<0.05); recurrence rate, the observation group was 3.3% (1/30), significantly lower than that of the control group 20.0% (6/30) P<0.05; adverse reactions, the incidence rate of the observation group was 13.3% (4/30), significantly lower than that of the control group 40.0% (12/30) P<0.05. Conclusion: Singulair combined with loratadine in treatment of cough variant asthma clinical effect is better than that of conventional treatment and inhaled corticosteroids, and low incidence rate of adverse reactions, good tolerance to treatment in children. 2014 Vol. 44 (10): 765-767 [Abstract] ( 771 ) HTML (1 KB)  PDF  (0 KB)  ( 417 ) 768 The emergency disposal of the evaluation of public health emergencies of H7N9 and SARS in China XIE Hongli1,2, ZHOU Fen1, WANG Chunlong2, ZHAO Feifei1, JIN Xiaodong1, PAN Yu1. Objective: Through the research emergency disposal of our country public health emergency of SARS and H7N9 avian flu, public health emergency disposal in our county is evaluated. Methods: The core elements of emergency SARS and H7N9 avian flu were compared and analyzed. Results: From SARS to H7N9 the core elements of the emergency response command, information transfer and treatment of cooperation in public health emergencies of emergency disposal had made progress, but there were some questions, such as the lack of unified coordination agency and executive force, delay of information transmission. Conclusion: Under the condition of rapid economic development, increasingly serious environmental problems, the mode that temporary emergency command center is given priority and cooperate with other departments is facing serious challenges, so we need to face problems, raise awareness, so that we can establish a perfect public health emergency disposal. 2014 Vol. 44 (10): 768-771 [Abstract] ( 701 ) HTML (1 KB)  PDF  (0 KB)  ( 443 )

Copyright © Editorial Board of JOURNAL OF WEZHOU MEDICAL UNIVERSITY Supported by:Beijing Magtech