中孕期血清AFP和free β-HCG水平与子痫前期的相关性

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Abstract Objective: To determine if second-trimester maternal serum alpha-fetoprotein (AFP) level and free β-HCG level can predict preeclampsia. Methods: Second-trimester maternal serum levels of AFP and β-HCG in pregnancies who delivered in Hangzhou Women’s Hospital from January 2015 to August 2016 were analyzed. A prospective case-control study included 55 mild preeclampsia patients, 36 severe preeclampsia patients and 100 control pregnant women. AFP and free β-HCG among groups were compared. The correlation of age, weight, gestational age, AFP, free β-HCG and preeclampsia, severe preeclampsia were analyzed by unconditional logistic regression analysis. The diagnostic efficacy of AFP and free β-HCG were evaluated by ROC curves. Results: AFP of mild preeclampsia group and severe preeclampsia group was significantly higher than control group (P<0.01). Logistic regression analysis showed that AFP was independent factor of mild and severe preeclampsia (P<0.05), but it has lower sensitivity. Conclusion: Higher second trimester maternal serum AFP level is a risk factor for preeclampsia. It can serve as a screening test for preeclampsia. However, single detection of AFP test is limited as the lower sensitivity. Combining other markers will make it more sufficient and reliable.

Key words： alpha-fetoproteins chorionic gonadotropin, beta subunit, human pre-eclampsia

Received: 01 June 2017

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	CHEN Yiming
	LU Sha
	HE Pei
	GU Linyuan
	ZHANG Yanzhen
	CHU Xuelian
	LIAN Jiejing
	ZHANG Min.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I2/115

[1] 孔红芳, 常亚清, 王芳, 等. HtrA与子痫前期相关性的研究进展[J]. 国际妇产科学杂志, 2017, 44(1): 56-59.
[2] SPAGGIARI E, RUAS M, DREUX S, et al. Management strategy in pregnancies with elevated second-trimester maternal serum alpha-fetoprotein based on a second assay[J].Am J Obstet Gynecol, 2013, 208(4): 303.e1-7.
[3] OLSEN RN, WOELKERS D, DUNSMOOR-SU R, et al. Abnormal second-trimester serum analytes are more predictive of preterm preeclampsia[J]. Am J Obstet Gynecol, 2012. 207(3): 228.e1-7.
[4] 中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2015)[J]. 中华妇产科杂志, 2015, 50(10): 721-728.
[5] 谢幸, 苟文丽. 妇产科学[M]. 8版. 北京: 人民卫生出版社, 2013: 64-70.
[6] DEHGHANI-FIROUZABADI R, TAYEBI N, GHASEMI N,
et al. The association between second-trimester maternal serum alpha-fetoprotein in 14-22 weeks and adverse pregnancy outcome[J]. Acta Med Iran, 2010, 48(4): 234-238.
[7] TACHE V, BAER R J, CURRIER R J, et al. Population-based biomarker screening and the development of severe preeclampsia in California[J]. Am J Obstet Gynecol, 2014, 211
(4): 377.e1-8.
[8] BREDAKI F E, MATALIOTAKIS M, WRIGHT A, et al. Maternal serum alpha-fetoprotein at 12, 22 and 32 weeks’ gestation in screening for pre-eclampsia[J]. Ultrasound Obstet Gynecol, 2016, 47(4): 466-471.
[9] SHENHAV S, GEMER O, VOLODARSKY M, et al. Midtrimester triple test levels in women with severe preeclampsia and HELLP syndrome[J]. Acta Obstet Gynecol Scand, 2003, 82(10): 912-915.
[10] DAVIDSON E J, RILEY S C, ROBERTS S A, et al. Maternal serum activin, inhibin, human chorionic gonadotrophin and alpha-fetoprotein as second trimester predictors of pre-eclampsia[J]. BJOG, 2003, 110(1): 46-52.
[11] MORSSINK L P, HERINGA M P, BEEKHUIS J R, et al. The association between hypertensive disorders of pregnancy and abnormal second-trimester maternal serum levels of HCG and alpha-fetoprotein[J]. Obstet Gynecol, 1997, 89(5): 666-670.
[12] CNOSSEN J S,TER RIET G, MOL B W, et al. Are tests for predicting pre-eclampsia good enough to make screening viable? A review of reviews and critical appraisal[J]. Acta Obstet Gynecol Scand, 2009, 88(7): 758-765.
[13] WALLER D K, LUSTIG L S,CUNNINGHAM G C, et al. The association between maternal serum alpha-fetoprotein and preterm birth, small for gestational age infants, preeclampsia, and placental complications[J]. Obstet Gynecol, 1996, 88(5): 816-822.