局部晚期直肠癌新辅助放化疗疗效与血管内皮生长因子水平的关系

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Abstract Objective: To investigate the relationship between levels of serum vascular endothelial growth factors (sVEGF) and effectiveness of neoadjuvant chemoradiotherapy on locally advanced rectal cancer. Methods: Levels of sVEGF were measured by enzyme-linked immunosorbent assay (ELISA) before and after treatment in 58 patients with locally advanced rectal cancer. The relationship between levels of sVEGFs and response of neoadjuvant chemoradiotherapy was analysed. Results: Levels of sVEGF were significantly decreased after treatment (P<0.01). Levels of sVEGF were different among patients with different pathological grades (P<0.05). Conclusion: The change of sVEGF level is able to evaluate the effectiveness of neoadjuvant chemoradiotherapy on locally advanced rectal cancer.

Key words： rectal neoplasms neoadjuvant chemoradiotherapy vascular endothelial growth factor

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	ZHU Shengyu
	SHEN Lerong
	YE Xianghua

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I1/63

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