白藜芦醇通过调节Ca2+浓度对小鼠外周疼痛的影响及作用机制

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Abstract Objective: To explore whether Ca2+, especially L-voltage-gated Ca2+ channels and Ca2+/caffeine-sensitive pools are involved in a algesic, effects and mechanisms in resveratrol-induced antinociception. Methods: Tail flick test was used to assess allodynia in mice treated with resveratrol (10, 20, 40 mg/kg, p.o.) alone or the combination of resveratrol or MK801 (0.5 mg/kg, i.p.) or nimodipine (2.5, 5, 10 mg/kg, i.p.) or CaCl2 (25, 50, 100, 200 nmol per mouse, i.c.v.) or ryanodine (0.25, 0.5, 1, 2 nmol per mouse, i.c.v.) or EGTA (5, 15, 30 nmol per mouse, i.c.v.). Results: The results showed that resveratrol increased the tail flick latency in the tail flick test (P<0.01). The effect of resveratrol was strengthened by MK801 or nimodipine (P<0.05). Central administration of Ca2+, however, diminished the antinociceptive effect of resveratrol (P<0.05). In contrast EGTA or ryanodine administered centrally improved the antinociceptve effect (P<0.05). Conclusion: The effect of resveratrol was enhanced by MK801, nimodipine, EGTA and ryanodine, while central administration of Ca2+, reduced the antinociceptive effects of resveratrol. The findings suggest that resveratrol produces effects on antinociception through regulation of calcium channels and calcium/caffeine-sensitive pools.

Key words： resveratrol calcium channels pain mice

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	WANG Lin
	PAN Jianchun

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I1/53

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