不同血压参数对高血压脑出血患者急性期预后的影响

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Abstract Objective: To study the effect of blood pressure parameters on the outcome of the patients with cerebral hemorrhage in the acute stage. Methods: Patients admitted in the neurology emergency clinic of the First Affiliated Hospital of Wenzhou Medical University were collected within 6 hours after onset from December 2010 to January 2013. Their blood pressure was recorded, relevant information was collected and all the cases were followed up for 3 months after stroke. Non-conditional logistic regressions analysis was adopted as the statistical method. To study the factors which affected the outcome of the first 7 days and 3 months after stroke. Results: In total 66 cases were analyzed. Multiplicity showed that the patient’s age (P=0.01, OR=1.19, 95%CI=1.04-1.36), the volume of hematoma (P<0.001, OR=1.34, 95%CI=1.12-1.59), the highest systolic pressure in the first 24 hours (P=0.02, OR=1.10, 95%CI=1.02-1.20) and the average systolic pressure in the first 7 days (P=0.01, OR=0.79, 95%CI=0.66-0.94) were the four independent factors associated with the outcome on the seventh days. The ROC curve was used to screen the boundary value, suggesting that the range of blood pressure in 151.5-178.5 mmHg was beneficial to the patients in acute period. The factors of age and the basic NIHSS were the independent factors connected with outcome of 3 months. Conclusion: The highest systolic pressure within the first 24 h (P=0.03, OR=1.09, 95%CI=1.01-1.17) and the average systolic pressure in the first 7 days (P=0.01, OR=1.27, 95%CI=1.07-1.50) could be used as the independent predictors for the outcome of acute stage of patients with cerebral hemorrhage, and a suitable range of blood pressure was beneficial for the outcome of the disease. The parameters of blood pressure could not be used as independent predictors for the outcome of 3 months in patients with cerebral hemorrhage.

Key words： cerebral hemorrhage hypertension systolic pressure multiplicity

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	FENG Liang
	WANG Zhen
	ZHANG Zheng
	YE Zusen
	NIU Xiaoting
	HAN Zhao

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I1/49

[1] DAVIS S M, BRODERICK J, HENNERICI M, et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage[J]. Neurology, 2006, 66(8): 1175-1181.

[2] ZHANG Y, REILLY KH, TONG W, et al. Blood pressure and clinical outcome among patients with acute stroke in Inner Mongolia, China[J]. Hypertension, 2008, 26(7): 1446-1452.

[3] ANDERSON C S, QURESHI A I. Implications of INTERACT2 and other clinical trials: blood pressure management in acute intracerebral hemorrhage[J]. Stroke, 2015, 46(1): 291-295.

[4] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2014)[J]. 中华神经科杂志, 2015, 48(6): 435-444.

[5] ANDERSON C S, HUANG Y, WANG J G, et al. Intensive blood pressure reduction in acute cerebral haemorrhage trial

(INTERACT): a randomised pilot trial[J]. Lancet Neurol, 2008, 7(5): 391-399.

[6] MANNING L, HIRAKAWA Y, ARIMA H, et al. Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial[J]. Lancet Neurol, 2014, 13(4): 364-373.

[7] TANAKA E, KOGA M, KOBAYASHI J, et al. Blood pressure variability on antihypertensive therapy in acute intracerebral hemorrhage: the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-intracerebral hemorrhage study[J]. Stroke, 2014, 45(8): 2275-2279.

[8] RÅDHOLM K, ARIMA H, LINDLEY R I, et al. Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study[J]. Age Ageing, 2015, 44(3):

422-427.

[9] DELCOURT C, ZHANG S, ARIMA H, et al. Significance of Hematoma Shape and density in intracerebral hemorrhage: the intensive blood Pressure Reduction in acute intracerebral Hemorrhage Trial Study[J]. Stroke, 2016, 47(5): 1227-1232.

[10] 郑国庆, 黄培新. 356例高血压幕上脑出血患者28天预后的影响因素[J]. 温州医学院学报, 2006, 36(1): 10-15.