不同饮酒量对脂肪肝患者肝功能和糖代谢的影响

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Abstract Objective: To compare the effects of different alcohol consumptions on liver function and glucose metabolism in fatty liver patients. Methods: The patients diagnosed with fatty liver from physical examination center, outpatient services and inpatient department, were divided into 3 groups: non-drinking group, modest-drinking group and heavy-drinking group according to the amount of alcohol consuming. Then, the details of patients’ information include general physical condition, liver function and glucometabolic index were compared. Results: A total of 75 non-drinking patients, 62 modest-drinking patients, 70 heavy-drinking patients were collected. The modest-drinking group had a significantly lower level of systolic blood pressure (SBP) compared with other two groups and a significantly lower level diastolic blood pressure (DBP) compared with heavy-drinking group (P<0.05). In the comparison of body mass index (BMI) and waist-hip ratio (WHR), the modest-drinking group was the smallest (P<0.05). The modest-drinking group had significantly lower alanine transaminase (ALT), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and significantly higher high-density lipoprotein cholesterol (HDL-C) than those of other two groups (P<0.05). The modest-drinking group had significantly lower hemoglobin A1c (HbA1c) and homeostasis model assessment-insulin resistance (HOMA-IR), significantly higher insulin action index (IAI) than other two groups (P<0.05). Conclusion: Compared with the patients of non-drinking group and heavy-drinking group, the patients in modest-drinking group could

benefit from blood pressure, BMI, WHR, liver function, cardiovascular system, insulin resistance and so on.

Key words： fatty liver modest alcohol drinking insulin resistance ultrasonography

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	LU Dongdong
	WU Jinming
	Xie Min
	Zheng Liyu

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I1/38

[1] GUNJI T, MATSUHASHI N, SATO H, et al. Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population[J]. Am J Gastroenterol, 2009, 104(9): 2189-2195.

[2] HAMAGUCHI M, KOJIMA T, OHBORA A, et al. Protective effect of alcohol consumption for fatty liver but not metabolic syndrome[J]. World J Gastroenterol, 2012, 18(2): 156-167.

[3] 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 中国非酒精性脂肪性肝病诊疗指南(2010年修订版)[J]. 中国医学前沿杂志, 2012, 4(7): 4-10.

[4] LAZO M, HERNAEZ R, EBERHARDT M S, et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination survey, 1988-1994[J]. Am J Epidemiol, 2013, 178(1): 38-45.

[5] DUNN W, XU RSCHWIMMER J B. Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease[J]. Hepatology, 2008, 47(6): 1947-1954.

[6] DEGRACE P, MOINDROT B, MOHAMED I, et al. Moderate consumption of beer reduces liver triglycerides and aortic cholesterol deposit in LDLr-/- apoB100/100 mice[J]. Atherosclerosis, 2006, 189(2): 328-335.

[7] NAKANISHI N, SUZUKI KTATARA K. Alcohol consumption and risk for development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men[J]. Diabetes Care, 2003, 26(1): 48-54.

[8] DIXON J B, BHATHAL P SO’BRIEN P E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese[J]. Gastroenterology, 2001, 121(1): 91-100.

[9] BECHMANN L P, ZAHN D, GIESELER R K, et al. Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells[J]. Hepatol Res, 2009, 39(6): 601-608.

[10] HAMAGUCHI M, KOJIMA T, ITOH Y, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat ac-

cumulation[J]. Am J Gastroenterol, 2007, 102(12): 2708-2715.

[11] XU A, WANG Y, KESHAW H, et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice[J]. J Clin Invest, 2003, 112(1): 91-100.

[12] SIERKSMA A, PATEL H, OUCHI N, et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity[J]. Diabetes Care, 2004, 27(1): 184-189.

[13] HAMANO M, KAMADA Y, KISO S, et al. Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction: Health check-up study of Japanese men[J].Hepatol Res, 2013, 43(3): 238-248.

[14] SENMARU T, FUKUI M, OKADA H, et al. Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet[J]. Metabolism, 2013, 62(6): 851-860.

[15] NAKAJIMA T, KAMIJO Y, TANAKA N, et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage[J]. Hepatology, 2004, 40(4): 972-980.

[16] MENDEZ-SANCHEZ N, ARRESE M, ZAMORA-VALDES D, et al. Current concepts in the pathogenesis of nonalcoholic fatty liver disease[J]. Liver Int, 2007, 27(4): 423-433.

[17] NISHIYAMA Y, GODA N, KANAI M, et al. HIF-1alpha induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice[J]. J Hepatol, 2012, 56(2): 441-447.

[18] MUKAMAL K J, JADHAV P P, D’AGOSTINO R B, et al. Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohort[J]. Circulation, 2001, 104 (12): 1367-1373.