DRD4基因多态性对注意缺陷多动障碍儿童静息态脑功能磁共振的影响

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Abstract Objective: To investigate the influence of dopamine D4 receptor (DRD4) gene polymorphism on brain resting-state functional magnetic resonance imaging (rs-fMRI) in children with attention deficit hyperactivity disorder (ADHD). Methods: rs-fMRI data was acquired in carriers of the DRD4 4-repeat/4-repeat (4R/4R) allele (DRD4 4R/4R group, n=30) and carriers of a DRD4 2-repeat (2R) allele (DRD4 2R group, n=19) in children with ADHD. The imaging characteristics of rs-fMRI between two ADHD genotypes were compared by using the methods of regional homogeneity (ReHo) and functional connectivity. Results: Compared with ADHD with a DRD4 2R allele, ADHD with DRD4 4R/4R allele showed increased ReHo in the bilateral cerebellum posterior lobe, the bilateral lingual gyrus and the right temporal occipital lobe. The decreased ReHo regions were the left angular gyrus. DRD4 4R/4R group showed functional connectivity increased to the left angular gyrus in the right frontal lobe and the bilateral cerebellum lobe. The functional connectivity decreased regions included the bilateral occipital lobe and the left frontal lobe. Conclusion: ReHo values and functional connectivity magnitude of many brain regions are significantly different between two groups of children with ADHD with different DRD4 genotypes. These findings could advance the understanding of the effects of DRD4 gene variation on children with ADHD in resting state.

Key words： attention deficit hyperactivity disorder dopamine D4 receptor resting-state functional magnetic resonance imaging

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	QIAN Andan
	WANG Meihao
	WANG Xin
	LIU Huiru
	LI Jiance
	YANG Chuang

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2018/V48/I1/26

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