肥胖对雌性大鼠交感肾上腺系统的长期程序化作用

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Abstract Objective: To investigate the long-term programming effects of obesity on the sympathoadrenal system in female rats. Methods: The litter size was adjusted to 4 pups per litter for the treatment group and 12 neonates per dam in the controls at postnatal day 0. Body weights were measured weekly. Vaginal opening and vaginal cytology smears were monitored from postnatal day 28. At the 10 weeks of age, the sympathetic nerve activity in adrenals and ovaries were detected by immunohistochemistry and the expression of TH mRNA in the locus coeruleus were investigated by in situ hybridization. Results: As compared to normal litters, the small litter rats were obesity throughout life. The puberty onsets were obviously advanced (35.5±0.8 d in treatment groups vs.37.6±0.3 d) in controls. The immuno-staining of TH were significantly enhanced in both the ovaries and adrenals in small litters. The level of TH mRNA in the locus coeruleus was significantly increased in small litters. All the differences were statistically significant (P<0.05). Conclusion: Obesity programmed the reproductive function of female rats by up-regulation of the sympathoadrenal system.

Key words： obesity adrenal ovary reproductive function sympathetic nerve rats

Received: 25 November 2013

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	WU Xueqing1
	YANG Simeng1
	LI Yuehua1
	ZHOU Qiangyong1
	CHEN Haiyan1
	LI Haiying2

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I3/157

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