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| The diagnostic significance of positive thyroid autoantibody in the first trimester in intrahepatic cholestasis of pregnancy |
| GAO Bo1, LI Hongmei1, SUN Jianli1, YANG Xuefang1, SHEN Beibei2. |
| 1.The Second Department of Obstetrics, Shaoxing Women and Children’s Hospital, Shaoxing, 312000; 2.Department of Nosocomial Infection, Shaoxing Women and Children’s Hospital, Shaoxing, 312000 |
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Abstract Objective: To investigate the diagnostic significance of positive antithyroid antibody (ATAb) in the first trimester in intrahepatic cholestasis of pregnancy (ICP). Methods: Select 120 cases of ICP pregnant who delivery in Shaoxing Women and Children’s Hospital with complete data from January 2016 to December 2016 as observation group, randomly selecte 120 cases of healthy pregnant according to the same proportion and during the same period as control group. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) are respectively determined in both the first trimester and the time of delivery in our hospital. Then statistics the number of positive ATAb cases. Compare and analyze the data of the two groups. Results: The observation group are compared with the control group, TPOAb in the first trimester increased significantly (Z=-2.309, P=0.021), institutional delivery gestational age significantly earlier (t=-7.318, P<0.001), TSH and TPOAb increased significantly (t=3.558, Z= -1.991, P<0.05) Conclusion: There is a certain relationship between positive antithyroid antibody in the first trimester and the occurrence and development of ICP. It have a certain significance to monitor thyroid autoantibody in the first trimester for early detection of ICP.
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Received: 14 April 2017
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