温州地区儿童前白蛋白、胆碱酯酶参考区间建立

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1387 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To establish the biological reference interval of serum prealbumin and cholinesterase for children (infant to school-age children) in Wenzhou. Methods: Retrospective study was adopted. The data of healthy infant (3 months to 12 years old) who visited the Second Affiliated Hospital of Wenzhou Medical University during April 2016 to March 2017 was collected. The qualified persons were divided into 6 groups according to gender and age, namely 3 months-3 years old (male, female infant group), -6 years old (male, female preschool group), 12 years old (male, female school-age group). By eliminating outliers within each group, 1 441 cases get qualified. Statistical methods was applied in comparing PA and CHE levels among the groups, if there was no statistical significance (P>0.05), the two age groups were merged, otherwise they won’t be merged. Results: The children’s serum PA reference intervals were 114.9-231.3, 126.4-237.4 and 136.7-273.5 mg/L for 3 months-3 years old, 4-6 years old, 7-12 years old. The difference of serum PA between male and female with the same age groups had no statistical significance (P>0.05). PA level was positively correlated with age (r=0.497, P<0.01). The children’s serum CHE reference intervals were 7 014-14 900, 7 079-14 246, 6 709-13 163 U/L for 3 months-6 years old, 7-12 years old (male), 7-12 years old (female). In addition to the school age group, the difference of serum CHE between male and female with the same age groups had no statistical significance (P>0.05). CHE level was not correlated with age (r=0.017, P>0.05). Conclusion: According to the research, reference intervals of PA and CHE are established for children at different age groups in the laboratory and reference in assessing children’s nutritional status and liver function are provided for clinicians.

Key words： prealbumin cholinesterase child reference intervals

Received: 24 February 2017

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Shanshan
	NI Li
	ZHU Lidan
	XU Xiaoyuan
	DING Hongxiang.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I11/824

[1] 李立, 田刚. 血清前白蛋白的研究进展[J]. 国际检验医学杂志, 2007, 28(3): 247-250.
[2] 李宏良, 张东军, 孙志坚. 肝病患者血清前白蛋白、载脂蛋白-A1、胆碱酯酶、γ-谷氨酰转肽酶、凝血酶原时间、总胆汁酸的变化及临床意义[J]. 中华传染病杂志, 2016, 34(3): 182-185.
[3] 钟堃, 王薇, 何法霖, 等. 我国九项常规生化项目参考区间与现行行业标准的比较和分析[J]. 中华检验医学杂志, 2014, 37(9): 709-711.
[4] 胡亚美, 江载芳, 诸福棠. 实用儿科学[M]. 7版. 北京: 人民卫生出版社, 2002: 2-4.
[5] NCCLS. Defining, Establishing, and Verifying Referencce Intervals in the Clinical Laboratory; Approved Guideline-Third Edition CLSI document: C28-A3[S]. Wayne, PA: NCCLS, 2008.
[6] HAMLIN C R, PANKOWSKY D A. Turbidimetric determination of transthyretin (prealbumin) with a centrifugal ana-lyzer[J]. Clin Chem, 1987, 33(1): 144-146.
[7] OZARDA Y. Reference intervals: current status, recent developments and future considerations[J]. Biochem Med (Zagreb), 2016, 26(1): 5-16.
[8] 叶应妩, 王毓三. 全国临床检验操作规程[M]. 2版. 南京: 东南大学出版社, 1997: 155-158.
[9] ZIERK J, ARZIDEH F, HAECKEL R, et al. Pediatric reference intervals for alkaline phosphatase[J]. Clin Chem Lab Med, 2017, 55(1): 102-110.
[10] DE ONIS M, ONYANGO A W, BORGHI E, et al. Development of a WHO growth reference for school-aged children and adolescents[J]. Bull World Health Organ, 2007, 85(9): 660-667.
[11] 王薇, 钟堃, 白玉, 等. 全国常规化学检验项目参考区间现状调查分析[J]. 中华检验医学杂志, 2011, 34(12): 1139-1143.
[12] 连丽丽. 长春市地区儿童血清免疫球蛋白生物参考区间建立[J]. 中华检验医学杂志, 2015, 38(3): 191-195.
[13] 王卓. 血清前白蛋白检测的临床应用[J]. 中国医学创新, 2010, 7(13): 184-185.
[14] 叶小姣. 儿童医院感染败血症病原菌及感染率10年变迁[J]. 温州医科大学学报, 2015, 45(11): 834-837.
[15] 张金平. 血液白细胞参数、C-反应蛋白和降钙素原在血液感染诊断中的应用[J]. 温州医科大学学报, 2015, 45(6): 454-456.
[16] 黄钰君. 广州市儿童血清前白蛋白参考范围调查[J]. 透析与人工器官, 2010, 21(3): 37-40.
[17] PIPLE J, GORE R, PURBIYA P, et al. Food Choices and consequences for the nutritional status: insights into nutrition transition in an hospital community[J]. PLoS One, 2015, 10(11): e0140807.
[18] 刘静, 李倩. 胆碱酯酶与临床相关疾病的研究进展[J]. 中国实用医药, 2014, 9(5): 258-260.