无视网膜病变糖尿病患者黄斑色素密度分析

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Abstract Objective: To compare macular pigment optical density (MPOD) between healthy Chinese people and type 2 diabetic patients without retinopathy using the one-wave length reflectometry and to evaluate the correlation of MPOD with serum lipid levels. Methods: Forty-one type 2 diabetes without retinopathy and 21 healthy controls were enrolled in this study. All subjects underwent blood tests which included glucose (GLU), glycated hemoglobin (HbA1c), cholesterol (CHOL), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), creatinine (CR), blood urea nitrogen (BUN), retinol binding protein (RBP) and homocysteine (HCY). MPOD (including mean OD: mean macular pigment optical density and max OD: maximum macular pigment optical density) was measured with one-wavelength ophthalmoscope. Results: Mean OD of type 2 diabetes was lower than the normal controls [(0.15±0.03) du vs. (0.16±0.02) du, P<0.05]. Mean OD level was positively correlated with HDL (r=0.28, P<0.05). Conclusion: Mean OD in diabetic patients without retinopathy is lower than that of healthy controls, and MPOD may affected by HDL levels.

Key words： macular pigment optical density diabetes mellitus retinal diseases

Received: 23 March 2017

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	XU Lijuan
	YU Rui
	LYU Zhigang

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I11/820

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