注意缺陷多动障碍儿童5-HTTLPR长等位基因A-G单核苷酸多态性与静息态脑功能及行为学的相关性

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Abstract Objective: To study the differences of amplitude of low frequency fluctuation (ALFF) between genotypes of SLA and SLG with attention deficit hyeractivity disorder (ADHD) children using functional magnetic resonance imaging (fMRI) and the relationship between ALFF and behavioristic. Methods: Screened out the genotypes of SLA and SLG of ADHD children by PCR gene detection technology. And all of the ADHD children were scanned with fMRI scanner in the resting state, using ALFF to assess the resting state cerebral function. And the Conners children behavior questionnaire was used to assess the behavior status quo. Results: Compared with the SLG genotype, SLA genotype showed ALFF were increased in right superior frontal gyrus, left middle frontal gyrus, left insula, right limbic cingulate gyrus, and no brain region with decreased ALFF. The ALFF of left middle frontal gyrus was significantly negative correlative with impulse-hyperactivity ratings of conners children behavior questionnaire, and ALFF of right limbic cingulate gyrus was significantly negative correlative with impulse-hyperactivity ratings and conduct problem score. Conclusion: Compared with the SLG genotype, the SLA genotype shows more yauld cerebral functional activities, and tend to be more serious impulse-hyperactivity and conduct problem.

Key words： attention deficit hyperactivity disorder serotonin transporter polymorphism, single nucleotide magnetic resonance imaging

Received: 04 March 2017

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	Articles by authors
	ZHANG Xiaoyan
	LIANG Yan
	DU Songmei
	LIN Haixi
	WANG Weiqian
	CHEN Hong
	LIU Huiru
	WANG Meihao
	ZHAO Yongzhong
	YANG Chuang

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I11/781

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