右美托咪定在小儿气管异物取出术中的应用安全性评价

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Abstract Objective: To evaluate the safety of dexmedetomidine on pediatric patients undergoing removal of airway foreign body. Methods: Randomized controlled trials (RCTs) about the pediatric patients undergoning removal of airway foreign body receiving intravenous infusion of dexmedetomidine were searched in The Cochrane Library, Medline, CNKI, VIP, CBM up to March 2016. The methodological quality of the included literatures were evaluated, and meta-analyses were performed with The Cochrane Collaboration’s RevMan 5.0 software. Results: A total of 4 RCTs involving 227 pediatric patients were included. The results of meta-analyses showed: ①Dexmedetomidine significantly reduced the coughing ratio (OR=0.44, 95%CI: 0.21-0.92, P<0.05); ②Dexmedetomidine significantly reduced the airway-spasm ratio (OR=0.21, 95%CI: 0.05-0.86, P<0.05); ③Dexmedetomidine did not significantly reduce the breath holding ratio (OR=0.50, 95%CI: 0.22-1.14, P>0.05); ④Dexmedetomidine significantly reduced the airway-spasm ratio (OR=0.44, 95%CI: 0.21-0.92, P<0.05). Conclusion: Dexmedetomidine is a safe anesthestic for airway foreign body removal in children from general anesthesia, decreasing the perioperative respiratory adverse events (coughing, airway-spasm, hypoxemia). However, because of the limited quality of the included researchs, further verification with more high quality RCTs are needed.

Key words： dexmedetomidine paediatric bronchoscopy randomized controlled trial meta-analysis

Received: 21 February 2017

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	HUANG Congcong
	XU Fengyan
	WU Biyun
	LI Jun.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I10/758

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