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Safety of norepinephrine versus dopamine in the treatment of cardiogenic shock: A meta-analysis |
JIN Guangyong1, LIN Leqing1, ZHOU Menglu2, WANG Bin1, WANG Baiyong1. |
1.Department of Intensive Care Unit, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015; 2.Department of Internal Neurology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015 |
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Abstract Objective: To systematically evaluate the safety of norepinephrine versus dopamine for the treatment of cardiogenic shock. Methods: Clinical trials of norepinephrine versus dopamine in cardiogenic shock were selected from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP Data.Study selection, assessment of methodological quality and data extraction were undertaken by two investigators separately, according to the inclusion and exclusion criteria. Meta analysis was performed using Review Manager 5.3 software. Results: A total of seven clinical trials with 381 patients were included. The results of this meta-analysis showed that norepinephrine for the treatment of cardiogenic shock reduced 28-day mortality by 0.54 times, compared to dopamine (RR=0.54, 95%CI: 0.37~0.80, P=0.002). The incidence rate of arrhythmia in norepinephrine group was 0.27 fold than that in dopamine group (RR=0.27, 95%CI: 0.16~0.48, P<0.001). Conclusion: Norepinephrine is safe in the treatment of patients with cardiogenic shock, compared to dopamine.
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Received: 16 March 2017
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. [J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2020, 50(5): 428-431. |
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