不同剂量羟考酮复合丙泊酚对宫腔镜手术的麻醉效果

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Abstract Objective: To compare the efficacy of different doses of oxycodone combined with propofol and explore the appropriate dose of oxycodone for hysteroscopy. Methods: Sixty patients who were scheduled for hysteroscopy were randomly divided into 4 groups (n=15 each): three oxycodone plus propofol groups (group O1, group O2, group O3) and propofol group (group P). In Groups O1, O2 and O3, oxycodone 0.05, 0.1, 0.15 mg/kg were injected respectively. Normal saline 0.15 mL/kg was bolused in Group P. Subsequentlythe hysteroscope was inserted until loss of response with intravenous administration of propofol, followed by a continuous infusion of propofol until the withdrawal of hysteroscope. At each time point, SBP, DBP, HR, and SpO2 were recorded. Propofol induced dosage, maintenance dosage, total dosage, total propofol administration time, the consumption of propofol per minute, operation time, emergence time, discharge time, the incidence of adverse reactions during intraoperative and postoperative and VAS scores were recorded. Results: There was no significant difference in the operation time, maintenance dosage and the incidence of hypotension, bradycardia, body movement, and nausea and vomiting between the four groups. Compared with group P, propofol induced dosage, the consumption of propofol per minute and VAS scores were significantly decreased in groups O2 and O3, emergence time was significantly decreased in groups O1, O2 and O3, and the incidence of dizziness was significantly increased in group O3 (P<0.05). Compared with group O1, propofol induced dosage, the consumption of propofol per minute and emergence time were significantly decreased in groups O2 and O3, and VAS scores was significantly decreased in group O3 (P<0.05). Propofol induced dosage was lower in group O3 than that in group O2 (P<0.05). The incidence of oxygen desaturation was higher and discharge time was longer in group O3 than that in groups P, O1 and O2 (P<0.05). Conclusion: The optimum dose of oxycodone is 0.1 mg/kg when combined with propofol for hysteroscopy.

Key words： oxycodone propofol hysteroscopy

Received: 28 March 2017

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	MIAO Xianghui
	LI He
	JIANG Hui
	WU Yanqin
	LIN Han2

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I10/748

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