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| Effects of propofol on potassium channels of S1 neurons in rats |
| HE Jiongce1, ZHANG Yu2, LIU Xingkui2, YU Tian2, HUANG Qianyu1 |
| 1.Department of Anesthesia and Perioperative Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 2.Department of Anaesthesiology, Zunyi Medical College, Zunyi, 563003 |
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| Cite this article: |
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HE Jiongce,ZHANG Yu,LIU Xingkui, et al. Effects of propofol on potassium channels of S1 neurons in rats[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(10): 713-717.
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Abstract Objective: To explore the effects of propofol on voltage-gated potassium channels of primary S1 neurons in rats. Methods: Whole-cell patch clamp technique was used to record potassium currents of neurons. After application with propofol at different concentrations (10-300 μmol/L) in ACSF, the currents of outward potassium currents (IA) and delayed rectifier potassium currents (IK) were recorded to make current-voltage curve, steady-state activation curve and account characteristic parameters. Results: Propofol inhibited IA of S1 neurons in rats in a dose-dependent manner. It also inhibited the activation of IA, shifted the activation curve towards the deperpolarzating potential. Propofol inhibited IK of S1 neurons of rats in a dose-dependent manner. But it did not affect activation of IK. Conclusion: The results of this study provide new vidence that propofol shows an inhibitory effect on voltage-gated potassium channels in the thalamocortical circuit, which may play a role in the mechanisms of propofol-induced general anesthesia.
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Received: 20 February 2017
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