急性胰腺炎凝血功能与疾病预后的关系

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Abstract Objective: To explore the relationship among coagulation function, D-dimer and prognosis in acute pancreatitis (AP). Methods: Two hundred and eight patients with AP and fifty healthy people (control group) in the First Affliated Hospital of Wenzhou Medical University from January 2016 to December 2016 were enrolled. AP patients were divided into mild group (MAP group) and severe group (SAP group). Prothrombin time (PT), part of the activation of prothrombin time (APTT), concentration of fibrinogen (FIB), D-dimer and platelet functions were compared. The relevance to acute physiology and chronic health evaluation (APACHE II) and Ca2+ were analyzed. Results: The PT and FIB in AP patients were significantly higher than that in the control group (P<0.01). The PT, FIB, D-dimer and APACHE II score in SAP group were significantly higher than that in MAP group (P<0.01). Pearson correlation analysis showed that PT, FIB, CRP and D-dimer were negative correlation with Ca2+ (r=-0.317, -0.249, -0.392, -0.362, P<0.01), PT and D-dimer were significantly positive correlation with the APACHE II score (r=0.270, 0.203, P<0.01). Conclusion: There is coagulation dysfunction in AP patients, mainly exogenous coagulation way, it’ s closely associated with the severity and prognosis of diseases. PT plus D-dimer is a better predictive value for AP.

Key words： acute pancreatitis coagulation function prognosis

Received: 06 March 2017

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	A Yu
	YE Suzhen

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I9/683

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