转录因子SOX7对前列腺癌PC-3细胞生物学活性的影响及其机制

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Abstract Objective: To investigate the effects and mechanisms of transcription factor SOX7 on PC-3 cells proliferation, cell cycle, cell migration and invasion. Methods: PC-3 cells were transfected with high-expressed SOX7 recombinant plasmid (pCDNA3.1-SOX7) and further detected the changes of cell proliferation, cell cycle, migration, invasion, and related protein expressions. Results: After transfection with pCDNA3.1-SOX7, significant inhibition effects was shown in the PC-3 cell proliferation and G1/S cell cycle arrest, which were accompanied with decreased expressions of cyclin D1 and E. Furthermore, transfection of pCDNA3.1-SOX7 markedly decreased the cell migration distances and invasion capacity, with a reduction of the mesenchymal markers (MMP-2, MMP-9 and N-cadherin), however, the epithelial marker E-cadherin was increased. Conclusion: SOX7 inhibits PC-3 cell proliferation, cell cycle, migration and invasion through regulation of its related protein expressions.

Key words： SOX7 prostate cancer proliferation migration invasion

Received: 27 December 2016

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	ZHENG Bin
	WU Qiquan
	ZHOU Kewen
	WANG Gang
	REN Yu
	QI Honggang
	ZHU Weizhi
	WENG Guobin

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I9/678

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