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| Association analysis of the SOX10 polymorphism and Hirschsprung |
| LUO Chunfen1, LI Shengmiao1, PAN Zhiwen2, XU Jiachuan1, LIU Zhengji1, YU Linjun1 |
| 1.Department of Pediatric Surgery, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, 317000; 2.Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, 310058 |
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| Cite this article: |
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LUO Chunfen,LI Shengmiao,PAN Zhiwen, et al. Association analysis of the SOX10 polymorphism and Hirschsprung[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(9): 666-669.
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Abstract Objective: To determine the association between the variations of SOX10 gene and sporadic HD in Zhejiang province. Methods: Blood from 95 sporadic HD cases and 80 normal cases were collected. Direct sequencing and polymerase chain reaction amplification were used to analyze 4 exons of the SOX10 gene for mutations and polymorphisms. Results: In this study, 4 single nucleotide polymorphisms (SNPs) were identified. No SOX10 gene mutations was found with sporadic HD. Conclusion: There is no association between these 4 SNPs of the SOX10 gene and HD. The SOX10 gene may not be the susceptibility gene of HD.
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Received: 26 December 2016
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