宫内感染与胎母输血综合征及炎症相关细胞因子的相关性

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Abstract Objective: To explore the correlation and changes of serum level of cytokines between intra-amniotic infection (IAI) and feto-maternal hemorrhage (FMH). Methods: Eighty cases of premature rupture of membranes were selected as research object. According to pathological examination of placenta and umbilical cord after childbirth, all cases were assigned into observation group (40 cases) with IAI and control group (40 cases) without IAI respectively. All cases were performed Kleihaue-Betke test and used ELISA to detect serum levels of IL-6, TNF-α and IL-10 antepartum. Incidence of maternal FMH and changes of cytokines in patients with IAI were analyzed. Results: Compared with the total number of pregnant women in our hospital, the incidence of IAI was 0.54% (40/7 638), the incidence of FMH was 0.14% (11/7 638). However, the incidence of FMH in patients with IAI was 22.5% (9/40). The finding showed that 9 cases with Kleihaue-Betke test≥0.6% in observation group and 2 cases with Kleihaue-Betke test≥0.6% in control group. The incidence of FMH was statistically significant (P<0.05). The levels of IL-6 and TNF-α in serum in observation group and FMH group were higher than those in control group and group without FMH (P<0.05). The plasma concentrations of IL-10 was lower (P<0.05). Conclusion: In Patients with IAI, the incidence of FMH is increased. We can find the elevated levels of IL-6, TNF-α in serum and the reduced level of IL-10 in serum in patients with IAI complicating FMH. Changes of cytokines keep consistent with those change induced by IAI.

Key words： intra-amniotic infection feto-maternal hemorrhage Kleihaue-Betke test cytokines

Received: 18 March 2017

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	WU Liqun
	YAO Rui
	XU Qun
	CAI Pingsheng.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I8/604

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