巨细胞病毒感染患儿的听力特点分析及临床随访

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Abstract Objective: To explore the difference of auditory brainstem response (ABR) after human cytomegalovirus (HCMV) infection, then follow-up the children with hearing loss, so as to provide theory basis for clinical diagnosis and treatment. Methods: One hundred fifty-eight hospitalized cases of children with HCMV infection were collected from 2013 to 2014 in the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University. All of the patients were performed by ABR testing. The children with hearing loss were followed up in out-patient, and underwent ABR testing once again about 3-6 months later. Results: In the first ABR tested 158 cases, there were 120 cases with normal hearing , and 38 cases (55 ears) with hearing loss, among whom 42 ears (76%) were mild abnormal, 7 ears (12.7%) were moderate abnormal, 3 ears (5.5%) were severe loss and 3 ears (5.5%) were profound loss. All of the children were divided into three groups according to the months of age, respectively for≤3 months, 3 to 6 months, ≥6 months comparison difference in three groups
of children with hearing impairment was statistically significant (χ2=7.830, P=0.020). Compared two among three groups, the hearing impairment of 3 to 6 months group was higher than that of≤3 months group, and the difference was significant (χ2=5.725, P=0.017). The incubation period in normal hearing ear I, III, V wave pointed compared with normal children, the difference was statistically significant (P<0.05). 38 cases (55 ears) of children who had hearing loss were followed up, and performed ABR testing again. Five cases (7 ears) of children had persistent anomalies on hearing loss, among whom 3 ears were sensorineural hearing loss. 2 cases of children, who had bilateral hearing loss, were symptomatic HCMV infection. Three cases of children, who had unilateral hearing impairment, were asymptomatic infection. Conclusion: HCMV infection may resulted in hearing impairment, they usually are mild injury, sometimes are sensorineural hearing loss. The incidence rate of hearing impairment among children with different months is different. Hearing impairment has the characteristics of reversibility, regardless of first hearing testing is normal or not, long-term follow-up and hearing testing are suggested.

Key words： cytomegalovirus hearing follow up sensorineural hearing loss

Received: 09 January 2017

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	ZHANG Hu
	XU Zhiwei
	CHEN Yingying
	YE Wanding
	CHEN Yiping
	LI Changchong.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I8/599

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