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| Expression of lncRNA-AL049452 in the tissue of colorectal cancer and its clinical significance |
| SUN Xiangwei1, HU Yingying2, XU Jianfeng1, ZHANG Liang1, MAO Chenchen1, GUO Gangqiang3, HUANG Guanli4, SHEN Xian5, XUE Xiangyang3. |
| 1.Department of General Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027; 3.Department of Microbiology and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035; 4.Department of Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 5.Department of General Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027 |
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| Cite this article: |
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SUN Xiangwei,HU Yingying,XU Jianfeng, et al. Expression of lncRNA-AL049452 in the tissue of colorectal cancer and its clinical significance[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(8): 566-570.
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Abstract Objective: To explore the expression and clinical significance of lncRNA-AL049452 in colorectal cancer (CRC). Mothods: Eighty-four cases of CRC tissues and corresponding paracancerous tissues were collected. Quantitative real-time PCR (qRT-PCR) was used to detect the expression level of lncRNA-AL049452 in these tissue specimens. Correlation between the expression of lncRNA-AL049452 and clinicopathological features was analysed by Mann-Whitney U test. Kaplan-Meier survival curves was used to analysed overall survival time and disease-free survival time between different lncRNA-AL049452 levels. Receiver operating characteristic (ROC) curve was performed to observe the diagnostic value of lncRNA-AL049452 for colorectal cancer. Results: lncRNA-AL049452 expression level in CRC tissues was obviously higher than that in corresponding paracancerous tissues (P=0.0035). High expression of lncRNA-AL049452 indicated larger tumor size (P=0.024). The lncRNA-AL049452 high-expression group presented significantly lower disease-free survival rates than the low-expression group (log-rank=4.208, P=0.034). In addition, ROC curves analyse showed that the AUC of ROC curve was 0.723 (95%CI=0.613-0.832, P<0.001) with 86.0% sensitivity, 51.2% specificity. Conclusion: The high expression of lncRNA-AL049452 in tumor tissues may play an important role in the progression in CRC, and can serve as novel biomarker for the diagnosis and prognosis of CRC.
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Received: 31 July 2016
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