P53结合蛋白1在宫颈鳞癌中的表达及其临床意义

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Abstract Objective: To explore the expression of P53-binding protein 1 (53BP1) in the tissue of cervical squamous carcinoma and relationship among their clinical stages, the degree of differentiation, lesion of lymph node metastasis and size. Methods: Fifty-two cases of cervical squamous carcinoma, 30 cases of cervical intraepithelial neoplasia (CIN) and 20 cases of normal cervical tissue were selected. Then the real-time fluorescent quantitative PCR was adopted for the detection of 53BP1 mRNA expression, and the statistical analysis of its expression and its clinical pathological characteristics were complemented as well. Results: 53BP1 mRNA in cervical squamous carcinoma relative expression levels were significantly lower than that in normal tissue, and the difference was statistically significant (P<0.05). 53BP1 mRNA expression in the differentiation of cervical squamous carcinoma in higher group level was significantly higher than that in the group of poorly differentiated carcinoma of the cervix, and the difference was statistically significant (P<0.05). 53BP1 mRNA in cervical lymph node metastasis-free group relative expression levels were significantly higher than that in the cervical lymph node metastasis group, and the differences were statistically significant (P<0.05). Compared the expression levels in FIGO I group of cervical cancer and cervical carcinoma FIGO II group, and focus-group and small lesions 53BP1 mRNA, the difference was not statistically significant (P>0.05). Conclusion: 53BP1 expression in cervical squamous cancer reduction is associated with the degree of differentiation, lymphatic metastasis, and lesion size, while it is not significantly related in clinical stages.

Key words： uterine cervical neoplasms real-time fluorogentic quantitative PCR 53BP1

Received: 08 September 2013

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	ZHU Haiyan1
	JIN Weiwei2
	HU Yan1
	ZHENG Feiyun1

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I2/134

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