Th17细胞免疫应答对高危型人乳头瘤病毒感染宫颈疾病的影响

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Abstract Objective: To study the role of cellular immunity in patients of cervical cancer with high-risk human papillomavirus (HPV) infection mediated by Th17 cells and IL-17. Methods: The study groups included 28 cervical cancer patients, 29 CIN3 patients, 30 CIN2 patients, 26 CIN1 patients, 25 high-risk HPV infected healthy women and 30 patients with HPV negative. The percentage of Th17 cells in the peripheral blood was detected by flow cytometry. The concentration of IL-17 in serum was examined by ELISA. Results: During the disease progression of cervical lesions, the proportion of Th17 cells in the total CD4+ cells showed a gradually increased tendency compared with the controls. The proportions differed significantly among the study groups and the control group (P<0.05). During the disease progression of cervical lesions, levels of IL-17 in serum showed a gradually increased tendency and differed significantly among all groups (P<0.05), but comparisons between any two groups were no significant difference (P>0.05). Conclusion: This study indicates that the cellular immunoreaction mediated by Th17 cells and IL-17 may be related to the infection of high-risk HPV, which contributes to the disease progression of its associated cervical diseases.

Key words： Th17 cells interleukin-17 uterine cervical diseases human papillomavirus T-cell immunity

Received: 29 October 2016

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	XUE Jisen
	ZHU Hua
	ZHANG Shenghui
	LYU Jieqiang
	HU Yan

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I7/504

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