左西孟旦对脂肪乳剂复苏布比卡因所致大鼠离体心脏停搏的影响

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Abstract Objective: To investigate the effect of levosimendan on the resuscitation with lipid emulsion in bupivacaine-induced asystole in isolated rat hearts. Methods: Sixteen male Sprague-Dawley rats were randomly divided into two groups (n=8). Asystole was induced by bupivacaine in the Langendorff isolated heart perfusion model. The perfusate in the control group contained 2% lipid emulsion, while the perfusate in the experiment group contained levosimendan (5 μmol/L) and 2% lipid emulsion. The resuscitation time (Tr), heart rate (HR), heart rate-pressure product (RPP) , the maximum change rate of left ventricular pressure rise (+dp/dt) and coronary flow (CF) in the isolated hearts were all recorded until 40 min since the recovery phase. Results: All hearts in both groups achieved re-beating. Tr in two groups has no significant difference (P>0.05). Compared with the control group, the cardiac function parameter HR, RPP and +dp/dt increased significantly in the isolated heart of the experiment group during the 40 min recovery phase (P<0.05). CF of the heart in the experiment group was higher than that of the control group after re-beating (P<0.05). There were no ventricular arrhythmias in two groups. Conclusion: In the bupivacaine-induced asystole of isolated rat heart model, levosimendan can enhance the heart function without increasing the risk of ventricular arrhythmias after the resuscitation with lipid emulsion.

Key words： levosimendan lipid emulsion bupivacaine cardiac arrest resuscitation

Received: 13 January 2017

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	XIA Fangfang
	CHEN Hongfei
	JIN Zhousheng
	SHI Kejian
	CHEN Limei
	XU Xuzhong.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I7/496

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