不同促排卵方案在多囊卵巢综合征患者未成熟卵母细胞体外成熟治疗中的疗效比较

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Abstract Objective: To compare the effectiveness of two clinical stimulated protocols in vitro maturation (IVM) cycles of polycystic ovary syndrome (PCOS) patients. Methods: Laboratory and clinical results were analyzed retrospectively for PCOS patients in IVM from January 2005 to December 2015 in the First Affiliated Hospital of Wenzhou Medical University. The overall 164 cycles were divided into two groups according to the stimulation protocol used, group A, IVM followed standard luteal long protocol (116 cycles) and group B, mild stimulated IVM (48 cycles). Basal characteristic, laboratory and clinical outcomes were used to assess the influence of different stimulated IVM in PCOS patients. Results: In the group A, the total dose of gonadotropin (1 008.83±579.68) IU was statistically higher than that in group B (540.52±329.16) IU (P<0.05). Numbers of oocytes retrieved of group A was significantly lower than that in group B (P<0.05). The group A also showed lower miscarriage rates compared to the other group (8.11% vs. 20.00%, P<0.05). The differences of embryo implantation rate (23.18% vs. 24.37%), clinical pregnant rate (45.95% vs. 53.33%) and live birth rate (32.43% vs. 28.89%) between the two groups were not statistically significant (P>0.05). Conclusion: PCOS patients using IVF convert in IVM cycles or gonadotropin priming IVM received the similar clinical pregnant rate compared with traditional IVF. However, the lower miscarriage rate of IVM converted from conventional stimulated IVF may lead to more clinical application.

Key words： polycystic ovary syndrome in vitro maturation in vitro fertilization embryo transfer

Received: 07 July 2016

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	JIN Congcong
	WANG Peiyu
	LIN Jia
	WU Yanhong
	ZHOU Wei
	ZHAO Junzhao

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I6/441

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