实时组织弹性成像技术诊断肝纤维化的影响因素

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Abstract Objective: To identify the factors which could influence the liver fibrosis index (LFI) based on real-time tissue elastography for liver fibrosis staging. Methods: Two hundred and sixty-two consecutive patients with chronic hepatitis B were prospectively recruited between January 2015 and December 2016 in the First Affiliated Hospital of Wenzhou Medical University. Real-time tissue elastography was performed and the LFI was calculated for the patients. The relationships between the LFI and clinical or morphological parameters were analyzed using pearson correlation analysis. Thereafter, a stepwise multiple linear regression analysis was used to identify the variables to be independent associated with LFI. Results: Pearson correlation analysis showed that body mass index (BMI), platelet count, portal vein diameter, hepatic artery diameter, hepatic artery velocity, spleen thickness, spleen diameter, splenic index, splenoportal index, splenic artery diameter, splenic vein diameter, and splenic vein velocity were significantly associated with LFI (P<0.05). BMI, platelet count, splenic vein diameter, and splenic vein velocity were identified as the independent variables associated with LFI by stepwise multiple linear regression analysis (P<0.01). Conclusion: BMI, platelet count, splenic vein diameter, and splenic vein velocity are identified as the independent variables associated with LFI. Clinical data and laboratory data, especially the ultrasonic parameters may improve the performance of LFI in staging liver fibrosis in patients with chronic hepatitis B.

Key words： hepatitis B, chronic liver cirrhosis elasticity imaging techniques iver fibrosis index

Received: 20 January 2017

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	XU Shihao
	LIN Shuting
	YING Li
	LI Jia
	HU Yuanping.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I6/425

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