胎盘FAT/CD36表达与巨大儿发生的相关性

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Abstract Objective: To explore the correlation between expression of FAT/CD36 in placenta and macrosomia. Methods: The cases were collected from June 2014 to June 2016 in the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, including 44 macrosomia newborns and 45 normal birth weight newborns. A self-designed questionnaire was used to collect related information of pregnant women and their neonates, real-time fluorescent quantitative PCR (qPCR) was used to detect FAT/CD36 mRNA expression in placenta. Western blot was used to detect FAT/CD36 protein expression. The influencing factors of macrosomia were analyzed by multivariate logistic regression model. Results: qPCR and Western blot showed FAT/CD36 expression of macrosomia was significantly higher than that of healthy controls (P<0.05). The result of multivariate logistic regression analysis showed that high expression of FAT/CD36 mRNA expression was a risk factor, and the occurrence of macrosomia was influenced by gestational age, gestational weight gain and newborns sex. Conclusion: The up-regulation of FAT/CD36 in placenta may be correlated with macrosomia.

Key words： FAT/CD36 fetal macrosomia placenta

Received: 31 October 2016

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	WANG Chenchen
	LI Yimei
	SUNHao
	CAI Qianying
	XU Xiaoxi
	WANG Yaocheng
	WANG Yuhuan
	YAN Hongtao
	YANG Xinjun

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I6/416

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