应用光学相干断层扫描血管成像技术分析近视眼黄斑区微血管变化

Abstract
Figure/Table
References (0)
Related Citation (10)

Download: PDF (1890 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the alterations of myopic macular retinal capillaries and its correlation with retinal thickness using optical coherence tomography angiography (OCTA). Methods: Ninety eyes of 45 people were included in this study, divided into low myopia and emmetropia group 30 eyes of 15 people (control group), moderate myopia group 30 eyes of 15 people, high myopia group 30 eyes of 15 people. Acquisition of macular micro-vascular density and retinal thickness, then obtained the superficial and deep vascular graph by automatic stratification. The densities of 1 mm circle (fovea) and 3 mm circle ring (parafovea) in the center of macular fovea were analyzed using the built-in software. Results: There was a significant positive correlation between foveal superficial/deep density and the axial length (r=0.51, 0.52, P<0.05). There was a significant negative correlation between parafoveal superficial density and axial length (r=-0.34, P=0.01), but no significant correlation between parafoveal deep density and axial length (r=-0.03, P=0.79). There was a significant positive correlation between foveal superficial/deep density and the inner five-layer thickness of fovea (r=0.85, 0.82, P<0.05). There was no significant correlation between parafoveal superficial/deep density and the inner five-layer thickness of parafovea (r=0.16, 0.07, P>0.05). Conclusion: The density of retinal blood vessels in macular fovea will increase with increasing axial length and retinal thickness, while the density of retinal blood vessels will decrease with increasing of axial length but not directly related with the change of retina thickness in retinal parafovea. Clinical application of blood flow imaging technology should be taken account into myopia on the macular micro vascular impact.

Key words： optical coherence tomography angiography myopia macula microvasculature density retina

Received: 28 November 2016

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FENG Limiao
	YANG Ye
	HU Liang
	FANG Haizhen
	YANG Xiaoling
	CHEN Hao.

URL:

https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I6/391

[1] MIDELFART A, MIDELFART S. Prevalence of refractive errors among adults in Europe[J]. Arch Ophthalmol, 2005,123(4): 580.
[2] Kempen J H, Mitchell P, Lee K E, et al. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia[J]. Arch Ophthalmol, 2004,122(4): 495-505.
[3] ROSE K, SMITH W, MORGAN I, et al. The increasing prevalence of myopia: implications for Australia[J]. Clin Exp Ophthalmol, 2001, 29(3): 116-120.
[4] Sawada A, Tomidokoro A, Araie M, et al. Refractive errors in an elderly Japanese population: the Tajimi study [J]. Ophthalmology, 2008, 115(2): 363-370.
[5] WONG T Y, FOSTER P J, HEE J, et al. Prevalence and risk factors for refractive errors in adult Chinese in Singapore[J]. Invest Ophthalmol Vis Sci, 2000, 41(9): 2486-2494.
[6] PAN C W, WONG T Y, LAVANYA R, et al. Prevalence and risk factors for refractive errors in Indians: the Singapore Indian Eye Study (SINDI)[J]. Invest Ophthalmol Vis Sci,2011, 52(6): 3166-3173.
[7] Holden B A, Fricke T R, Wilson D A, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5):1036-1042.
[8] WANG X, KONG X, JIANG C, et al. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study[J]. BMJ Open, 2016, 6(3): e010791.
[9] YANG Y, WANG J, JIANG H, et al. Retinal microvasculature alteration in high myopia[J]. Invest Ophthalmol Vis Sci, 2016, 57(14): 6020-6030.
[10] LI H, MITCHELL P, LIEW G, et al. Lens opacity and refractive influences on the measurement of retinal vascular fractal dimension[J]. Acta Ophthalmol, 2010, 88(6): e234-240.
[11] SHIMADA N, OHNO-MATSUI K, HARINO S, et al. Reduction of retinal blood flow in high myopia[J]. Graefes Arch Clin Exp Ophthalmol, 2004, 242(4): 284-288.
[12] ZHAO Z, ZHOU X, JIANG C, et al. Effects of myopia on different areas and layers of the macula: a Fourier-domain optical coherence tomography study of a Chinese cohort[J].BMC Ophthalmol, 2015, 15: 90.
[13] NAKANISHI H, AKAGI T, HANGAI M, et al. Effect of axial length on macular ganglion cell complex thickness and on early glaucoma diagnosis by spectral-domain optical coherence tomography[J]. J Glaucoma, 2016, 25(5): e481-490.
[14] LI M, YANG Y, JIANG H, et al. Retinal microvascular network and microcirculation assessments in high myopia[J].Am J Ophthalmol, 2017, 174: 56-67.
[15] LIM L S, CHEUNG C Y, LIN X, et al. Influence of refractive error and axial length on retinal vessel geometric characteristics[J]. Invest Ophthalmol Vis Sci, 2011, 52(2): 669-678.
[16] KANEKO Y, MORIYAMA M, HIRAHARA S, et al. Areas of nonperfusion in peripheral retina of eyes with pathologic myopia detected by ultra-widefield fluorescein angiography [J]. Invest Ophthalmol Vis Sci, 2014, 55(3): 1432-1439.
[17] KUR J, NEWMAN E A, CHAN-LING T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease[J]. Prog Retin Eye Res, 2012, 31(5): 377-406.