外周血中性粒细胞/淋巴细胞比值与糖尿病患者下肢动脉病变的相关性

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Abstract Objective: To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and lower extremity arterial disease (LEAD) in T2DM patients. Methods: Six hundred and twenty-seven inpatients with T2DM were recruited in this study. The numbers of the white blood cell, neutrophils (N) and lymphocytes (L) as well as the NLR values of peripheral blood were detected. Based on the quartile of NLR, all patients were divided into four groups: Q1≤1.30 (n=159), Q2: 1.31-1.81 (n=154), Q3: 1.82-2.50 (n=156) and Q4≥2.51 (n=158). The relationship between NLR and LEAD in T2DM patients was discussed. Results: Logistic regression analysis showed the prevalence of LEAD was significant higher in Q3 (OR: 1.62, 95%CI: 1.03-2.55, P=0.037) and Q4 (OR: 1.84, 95%CI: 1.17-2.90, P=0.008) than that in Q1. After adjusting clinical characters and biochemical, the prevalence of LEAD was still higher in Q4 (OR: 1.75, 95%CI: 1.04-2.92, P=0.034). Conclusion: The prevalence of LEAD in T2DM patients increases with the rise of NLR.

Key words： neutrophil-to-lymphocyte ratio ankle brachial index inflammatory reaction diabetes mellitus, type 2 lower extremity arterial disease

Received: 25 April 2016

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	Shang Shuxia
	Song Guangyao
	Yu Dong
	Duan Lijun
	He Jingfeng
	Guo Li

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I4/286

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