|
|
Early identification of neutrophil-to-lymphocyte ratio for severe coronary artery stenosis in patients with chest pain |
BAI Hongyuan1, WANG Xiqiang2, WANG Tingzhong2, YANG Dandan2, NING Feifei2, BAI Ruhai3. |
1.Department of Cardiology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710000; 2.Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000; 3.Department of Epidemiology and Statistics, Xi’an Jiaotong University Health Science Center, Xi’an, 710000
|
|
Cite this article: |
BAI Hongyuan,WANG Xiqiang,WANG Tingzhong, et al. Early identification of neutrophil-to-lymphocyte ratio for severe coronary artery stenosis in patients with chest pain[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(4): 282-285.
|
|
Abstract Objective: To investigate the early identification of NLR for severe coronary artery stenosis in patients with chest pain. Methods: Clinical data of 484 patients who had undergone coronary angiography owing to pectoris symptom were retrospectively analyzed. Patients were divided into severe stenosis group and mild stenosis group based on Gensini scores. Logistic regression and receiver operator characteristic curve were used to analyze early identification of NLR for coronary artery stenosis. Results: Using multiple logistic regression analysis, advanced ages (OR=1.033, 95%CI: 1.013-1.054, P=0.001), male (OR=1.750, 95%CI: 1.062-2.883, P=0.028), LDL-C (OR=1.723, 95%CI: 1.232-2.411, P=0.001), and NLR (OR=1.345, 95%CI: 1.205-1.500, P<0.001) emerged as independent identification for the severe coronary artery stenosis. In receiver operating characteristics curve analysis, NLR>2.32 had 78.5% sensitivity and 62.6% specificity in identify the severity of coronary artery stenosis. Conclusion: High NLR is a powerful identification for the sverity of coronary artery stenosis in patients with chest pain.
|
Received: 16 April 2016
|
|
|
|
|
[1] ROGER V L, GO A S, LLOYD-JONES D M, et al. Executive summary: heart disease and stroke statistics—2012 update: a report from the American Heart Association[J].Circulation,2012, 125(1): 188-197.
[2] ROSS R. Atherosclerosis—an inflammatory disease[J]. N Engl J Med, 1999, 340(2): 115-126.
[3] WARNATSCH A, IOANNOU M, WANG Q, et al. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis[J]. Science, 2015, 34(6245): 316-320.
[4] AKPEK M, KAYA M G, LAM Y Y, et al. Relation of neutrophil/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention[J]. Am J Cardiol, 2012, 110(5): 621-627.
[5] KALAY N, DOGDU O, KOC F, et al. Hematologic param-
eters and angiographic progression of coronary atherosclerosis[J]. Angiology, 2012, 63(3): 213-217.
[6] Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2003, 26 Suppl 1: S5-20.
[7] National High Blood Pressure Education Program. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure[R]. Bethesda (MD): National Heart, Lung, and Blood Institute (US), 2004, Report No.: 04-5230.
[8] 方圻, 诸骏仁, 胡大一, 等. 中国成人血脂异常防治指南[J]. 中华心血管病杂志, 2007, 35(5): 390-419.
[9] GENSINI G G. A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606.
[10] TALEB S, TEDGUI A, MALLAT Z. IL-17 and Th17 cells in atherosclerosis: subtle and contextual roles[J]. Arterioscler Thromb Vasc Biol, 2015, 35(2): 258-264.
[11] DORING Y, SOEHNLEIN O, WEBER C. Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target[J]. Circ Res, 2014, 114(6): 931-934.
[12] HORNE B D, ANDERSON J L, JOHN J M, et al. Which white blood cell subtypes predict increased cardiovascular
risk?[J]. J Am Coll Cardiol, 2005, 45(10): 1638-1643.
[13] YARNELL J W, PATTERSON C C, SWEETNAM P M, et al. Haemostatic/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies[J]. Eur Heart J, 2004, 25(12): 1049-1056.
[14] BIAN C, WU Y, SHI Y, et al. Predictive value of the relative lymphocyte count in coronary heart disease[J]. Heart Vessels, 2010, 25(6): 469-473.
[15] SOEHNLEIN O, ZERNECKE A, WEBER C. Neutrophils launch monocyte extravasation by release of granule proteins[J]. Thromb Haemost, 2009, 102(2): 198-205.
[16] SIMON T, TALEB S, DANCHIN N, et al. Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction[J]. Eur Heart J, 2013, 34(8): 570-577.
[17] 谢福荣, 许化致, 姜亿一, 等. 320排动态容积CT评估钙化斑块对诊断冠状动脉狭窄程度的影响[J]. 温州医科大学学报, 2015, 45(8): 570-573.
[18] 李建斌, 李强, 李盛, 等. 64排螺旋CT评估冠状动脉及左心室功能[J]. 温州医科大学学报, 2014, 44(2): 144-147.
|
|
|
|