孕早期血红蛋白水平与妊娠期糖尿病的关联性

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Abstract Objective: To explore the relationship between maternal hemoglobin concentration (Hb) in early pregnancy and the incidence of gestational diabetes mellitus (GDM). Methods: In a case-controlled study, the clinical date of 109 women with GDM (GDM group) and 151 healthy pregnant women (control group) were analyzed retrospectively. Results: The univariate analysis revealed that the age, body mass index (BMI) before pregnancy, high Hb concentration at early pregnancy, systolic pressure and diastolic pressure at early pregnancy, educational level, gravidity and parity in the GDM group were higher than that in the control group (P<0.05). The subjects were divided into 4 quartiles in order of increasing Hb concentration level, among which Hb concentration and the incidence of GDM were compared. With the Hb concentration increasing the risk of GDM increased. A positive correlation was found between Hb concentration and the incidence of GDM by the spearman rank correlation (r=0.201, P=0.001). Multivariate logistic regression analysis revealed that, with adjustment for the confounding factor above-mentioned, high Hb concentration (Hb≥130 g/L) at early pregnancy had an increased risk of GDM (OR=3.54, 95%CI: 1.60～7.83, P=0.002). Conclusion: High Hb concentration at early pregnancy increases the incidence of GDM, Hb examining can be effective measure of screening for GDM.

Key words： diabetes, gestational hemoglobin risk factors

Received: 19 August 2013

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	SUN Rongrong
	ZHANG Wenmiao
	XIAO Biru
	YANG Mengmeng
	CHEN Qiuyue.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2014/V44/I2/109

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