皮肤科住院患者口腔念珠菌感染的病原学及相关因素

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Abstract Objective: To determinie the distribution of species among in-patients of dermatological department, investigate the risk factors associated with oral candidiasis and evaluate antifungal susceptibility profile of oral candida. To provide a theoretical basis of candida infection and prevention. Methods: Cluster sampling method was adopted in our study. Mucosal swab samplings were taken from the objects. The strains were identified by CHROMagar Candida agar medium, and API 20C AUX system for yeasts. Antifungal susceptibility was tested in vitro by the broth microdilution method. The risk factors was investigated by analysis of clinical data. Results: Oral candida carriage rate was 40.4% in in-patients of dermatological department. C. albicans accounted for 83.1% of the candida species. Infectious skin diseases, connective tissue disease, blister disease and use of antibiotics were risk factors associated with oral candidiasis. The percentage of resistant to itraconazole, ﬂuconazole and voriconazole were 8.5%, 4.4% and 1.2%. All of the isolates were susceptible to amphotericin B. Conclusion: The oral candida colonization rate in in-patients of dermatological department is high. The percentage of resistant to C. albicans is low, but high azole-resistance rate is found among non-C. albicans fungal species. In vitro antifungal susceptibility is necessary before antifungal therapy.

Key words： candidiasis, oral etiology microbial sensitivity tests

Received: 20 September 2016

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	ZHANG Youla
	LIU Dongmei
	ZHOU Xiaohua
	LOU Meiyang
	PAN Kangjian
	HONG Zhigang
	CHEN Wenying.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I4/277

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