卵泡期高孕激素状态下促排卵在卵巢储备功能低下患者中的应用

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Abstract Objective: To compare the embryo laboratory outcomes of different ovarian stimulation schemes in patients with diminished ovarian reserve, to explore the application value of progestin-primed ovarian stimulation scheme in patients with diminished ovarian reserve. Methods: A total of 228 cycles of patients with diminished ovarian reserve who received IVF/ICSI-ET treatment from November 2015 to July 2016 were analyzed retrospectively. They were divided into progestin-primed ovarian stimulation (Group A, 87 cycles), luteal-phase stimulation (Group B, 45 cycles) and mild stimulation (Group C, 96 cycles) according to treatment protocols. The basic situations and the embryo laboratory outcomes were compared and analyzed between Group A, Group B and Group C. Results: The basic situations in three groups were no significant differences (P>0.05). The dosage of Gn administration in Group B was significantly higher than those in Group A and Group C (P<0.05). The D3 quality embryo rate in Group A was significantly higher than Group C (P<0.05). The serum LH level of the patients in Group B on the day of HCG administration was significantly lower than that in Group A and Group C (P<0.05). The serum P level of the patients in Group B on the day of HCG administration was significantly higher than Group C (P<0.05). There were no significant differences in the retrieved oocytes number, mature oocytes number, D3 good-quality embryos number, available embryos number, the normal fertilization rate, the cleavage rate, the available embryo rate among three groups (P>0.05). Conclusion: Progestin-primed ovarian stimulation scheme can obtain higher D3 quality embryo rate and is a viable regimen for patients with diminished ovarian reserve.

Key words： diminished ovarian reserve in vitro fertilization-embryo transfer high progesterone status mild stimulation

Received: 18 September 2016

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	FU Yanghua
	YANG Tanchu
	XI Haitao
	ZHAO Junzhao

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I4/258

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