|
|
|
| A Meta-analysis of flurbiprofen axetil versus tramadol in postoperative analgesia effect and adverse drug reactions |
| ZOU Liangwang1, ZHAO Xiyue2, QIU Enyi3, XU Lijuan2, SHAN Yunfeng2. |
1.Department of Surgery, Wenzhou Longwan First People’s Hospital, Wenzhou, 325024; 2.Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.Department of Radiotherapy and Chemotherapy, Wenzhou Central Hospital, Wenzhou, 325000
|
|
| Cite this article: |
|
ZOU Liangwang,ZHAO Xiyue,QIU Enyi, et al. A Meta-analysis of flurbiprofen axetil versus tramadol in postoperative analgesia effect and adverse drug reactions[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2017, 47(3): 206-210.
|
|
|
Abstract Objective: To compare and analyze flurbiprofen axetil with tramadol in postoperative analgesic effect and the occurrence of adverse drug reactions. Methods: All the randomized controlled trials referring to the comparison of flurbiprofen axetil and tramadol in postoperative analgesia effect and adverse drug reactions were searched in the domestic and foreign databases (such as CNKI, WanFang database, Medline and Pubmed) in January 2006 to May 2015. The enrolled published literatures were analyzed using Meta-analysis method with RevMan 5.1 statistical analysis software. Results: Ten separate clinical randomized controlled trials including 728 cases were researched with the Meta-analysis. Objective responsiveness: there is no significant difference between the postoperative analgesia effect of flurbiprofen axetil group and that of tramadol group; But in the adverse drug reactions: the incidence of nauses and vomiting were lower in the flurbiprofen axetil group than that in the tramadol group (P<0.001), the RR and 95%CI were 0.36 (0.26-0.50). The incidence of dizziness was lower in the flurbiprofen axetil group than that in the tramadol group (P=0.01), the RR and 95%CI were 0.46 (0.26-0.83). The funnel plots showed no significant publication bias in each indexes. Conclusion: The roles of postoperative analgesia effect in flurbiprofen axetil group are similar to tramadol group, but the incidence of adverse drug reactions are less in the flurbiprofen axetil group than that in the tramadol group.
|
|
Received: 05 April 2016
|
| |
|
|
|
[1] 中华医学会麻醉学分会. 中国麻醉学指南与专家共识[M]. 2014版. 北京: 人民卫生出版社, 2014: 294-304.
[2] WHEATLEY B G, MADEJ T H, JACKSON I J, et al. The first year’s experance of an acute pain service[J]. Br J Anaesth, 1991, 67(3): 353-359.
[3] 姜晓芬. 盐酸曲马多静注术后镇痛的效果观察[J]. 温州医学院学报, 2000, 30(4): 328-329.
[4] 罗向阳. 氟比洛芬酯和盐酸曲马多治疗妇科腹腔镜后疼痛的临床效果[J]. 临床医药实践, 2014, 23(3): 238-240.
[5] 王琦, 余永华, 姚尚龙, 等. 氟比洛芬酯和曲马多超前镇痛应用于七氟醚麻醉的比较[J]. 国际麻醉学与复苏杂志, 2013, 34(12): 1079-1082.
[6] SU C H, SU Y H, CHOU C W, et al. Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis[J]. J Cardiothorac Surg, 2012, 7: 98.
[7] 韩云志, 许植, 赵军, 等. 氟比洛芬酯和盐酸曲马多治疗妇科腹腔镜手术后早期疼痛的研究[J]. 中国民族民间医药, 2010, 19(7): 111, 114.
[8] 林芩. 氟比洛芬酯与曲马多用于妇科宫腔镜手术超前镇痛的效应比较[J]. 福建医药杂志, 2010, 32(5): 123-125.
[9] 陈琦, 陶岩, 鄂爽, 等. 凯纷与曲马多在患儿扁桃体和腺样体术中的镇痛效果[J]. 华西医学, 2010, 10: 1883-1885.
[10] 戴载深. 氟比洛芬酯用于妇科腹腔镜术后镇痛的有效性和安全性评价[J]. 吉林医学, 2009, 30(13): 1263-1265.
[11] 张旭宇, 张涛, 林世清, 等. 氟比洛芬酯、氯诺昔康和曲马多用于妇科腔镜手术后镇痛效果的研究[J]. 实用医学杂志, 2008, 24(3): 449-451.
[12] 许睿, 张庆国, 刘辉, 等. 氟比洛芬酯与曲马多用于腹腔镜子宫切除术后静脉镇痛[J]. 中国新药杂志, 2007, 16(2): 161-163.
[13] 苏春华, 陈振光, 罗红鹤, 等. 氟比洛芬酯与曲马多用于重症肌无力患者术后镇痛的效果比较[J]. 广东医学, 2007, 28(10): 1691-1692.
[14] 赵娴, 冯智英, 叶素娟, 等. 氟比洛芬酯复合曲马多术后镇痛的疗效观察[J]. 临床麻醉学杂志, 2007, 23(6): 501-502.
[15] OHMUKAI O. Lipo-NSAID preparation[J]. Adv Drug Deliv Rev, 1996, 20(2): 203-207.
[16] 周双琼, 鄢建勤, 刘雪, 等. 腹腔镜术终运用氟比洛芬酯和氯诺昔康术后镇痛的比较[J]. 实用疼痛学杂志, 2006, 2(4): 216-218.
[17] 赵喜越, 繆剑霞, 王良荣, 等. 比较右美托咪定与曲马多预防围术期寒战效果的Meta分析[J]. 温州医科大学学报, 2014, 44(12): 896-900.
|
|
|
|
