14-3-3 zeta蛋白过表达与他莫昔芬治疗乳腺癌耐药的关系

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Abstract Objective: To investigate the relationship between 14-3-3 zeta protein over-expression and tamoxifen resistance in breast cancer. Methods: The 14-3-3 zeta protein expression was detected in the cancerous tissues of 80 breast patients using immunohistochemistry. Based on the follow-up visits, survival status in both high and low 14-3-3 zeta expression groups were analyzed. Results: The total positive ratio of 14-3-3 zeta protein expression in subjects was 96.25% (77/80). Among the total positive ratio, the strong positive ratio, moderate positive ratio and weakly positive ratio were 51.25% (41/80), 23.75% (19/80) and 21.25% (17/80), respectively. The 14-3-3 zeta protein over-expression was related to clinical pathological features. According to the follow-up results, the patients in 14-3-3 zeta high expression group would cause the relapse easily for a short survival time. The results of vitro experiment indicated that the Tamoxifen resistance was enhanced after increasing the expression of 14-3-3 zeta protein. Conversely, the down-regulation of 14-3-3 zeta protein expression would reduce the tamoxifen resistance. Conclusion: As a biomarker of tamoxifen resistance, 14-3-3 zeta protein can be used for evaluating therapeutic efficacy by detecting its expression in breast cancer tissue.

Key words： breast neoplasms 14-3-3 zeta immunohistochemistry tamoxifen cell apoptosis

Received: 21 September 2016

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	LING Ren
	LING Jin
	CHEN Zhonghua
	LIU Dandan
	ZHAO Hongqi
	KE Youtao.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I3/192

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