二肽酶IV在胃癌中的表达及临床意义

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Abstract Objective: To evaluate the expression of dipeptidyl peptidase IV (DPP IV) in gastric carcinoma tissue and matched para-tumor tissues, then its clinical pathologic significance for gastric carcinoma was investigated. Methods: One hundred and twelve cases gastric carcinomas tissues and the same number of matched para-tumor tissues were selected, expressive difference of DPP IV gene between carcinoma tissues and their matched para-tumor tissues was measured by immunohistiochemistry; with protein concentration level of DPP IV measured by Western blotting methods. Results: The expressive loss number for DPP IV was 3 (2.7%) in 110 normal gastric tissues, while lossed in 78 gastric carcinomas; and the level of DPP IV decreased obviously in DPP IV positive tissues; DPP IV is an independent prognostic factor of gastric carcinoma by multiple factor analysis. Conclusion: Loss of DPP IV’s expression is an independent poor prognostic factor of gastric carcinoma.

Key words： dipeptidyl peptidase IV stomach neoplasm pathology prognosis

Received: 05 March 2016

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	Articles by authors
	TIAN Jie
	ZHANG Zhi’an
	SUN Guoxing
	XIAO Baozeng
	Zhang Wenchao
	Yang Jitao
	Zhang Qingyong
	Yin Xiao
	Geng Guowang.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I2/140

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