成纤维细胞激活蛋白α在神经胶质瘤中的表达及临床意义

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Abstract Objective: To explore the expression of FAP-α in human gliomas, and its relationship between clinical characteristics and prognosis. Methods: Expression level of FAP-α protein was detected with immunohistochemistry in 33 cases of human gliomas and 7 cases of normal brain tissue, followed by subsequent clinicopathological correlative studies. Meanwhile, all patients were followed up, the relationship between the expression level of FAP-α and the glioma prognosis were studied. Furthermore, brain tumor molecular database (Rembrandt) was searched to investigate the relationship between the FAPmRNA expression and prognosis. Results: Comparing the expression intensities (IOD) of FAP-α protein in low-grade gliomas with those in high-grade gliomas, it was significantly different (P<0.01); the expressions of FAP-α and the pathological grades of glioma were positively correlated (r=0.673, P<0.01). There was low or no expression in 7 cases of normal brain tissue; Comparing with low grade glioma (P<0.05) and high grade glioma (P<0.01), there was significantly difference. The FAP-α expression was not significantly correlated with gender or tumor size or surgical degree and age (P>0.05). By survival analysis, overall survival time was significantly difference between the Low FAP-α and High FAP-α (P<0.01), and the expression of FAP-α was a independent prognostic factor in human gliomas (P<0.05). According to the results obtained from Rembrandt, patients with high FAP mRNA-expressing glioma showed statistically poorer prognoses compared with patients with low FAP mRNA-expressing glioma. Conclusion: FAP-α is expressed in human gliomas, which is positively correlated with the pathological grade of gliomas, and its high expression may suggest a poor prognosis.

Key words： fibroblast activation protein α glioma immunohistochemistry prognosis

Received: 17 May 2016

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	CHEN Yuan
	SU Zhipeng
	JIN Yong
	ZHENG Weiming.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I2/115

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