中药和万汶在预防卵巢过度刺激综合征中的临床应用比较

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Abstract Objective: To compare the effect and clinical outcome of traditional Chinese medicine and Voluven on preventing ovarian hyper-stimulation syndrome during in vitro fertilization or intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET). Methods: Prospective randomized case-control study was conducted. 74 women with high risk of OHSS on human chorionic gonadotropin (HCG) injection day were divided into 3 groups, 24 in traditional Chinese medicine group (Group A), 24 in Voluven group (Group B) and 26 in the combined group (Group C). In Group A, traditional Chinese medicine was used for 7 days since ovum pick up (OPU) day, in Group B, 500 mL Voluven vein injection were used for three days, and in Group C, traditional Chinese medicine and Voluven were both used. We compared their laboratory and clinical outcomes, vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and Nitric oxide (NO) in both serum and follicular fluid on HCG injection day, OPU day, and ET day. Results: The pregnant rate of Group A (72.22%) was higher than that of Group B (52.63%) and Group (58.82%), but without statistic differences. No patients developed severe OHSS. There were no statistically differences in the moderate and mild OHSS rate and the result of VEGF, IL-6 and NO in all three groups. Conclusion: Both traditional Chinese medicine and Voluven have influence on the concentration of VEGF, IL-6 and NO and can avoid severe OHSS. The use of Voluven seems to produce a higher pregnant rate. Combined method can not improve the clinical and laboratory result.

Key words： ovarian hyperstimulation syndrome Voluven traditional Chinese medicine vascular endothelial growth factor interleukin-6 nitric oxide

Received: 30 May 2016

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	WANG Peiyu
	ZHAO Junzhao
	LIN Jia
	LU Yibin
	ZHENG Jiujia
	JIN Congcong
	JIN Wumin

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I2/104

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