核磁共振氢谱检测糖尿病不同发病阶段额叶和枕叶的代谢变化

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Abstract To investigate the metabolic changes of frontal lobe and occipital lobe in different stages of diabetes. Methods: The frontal lobe and occipital lobe were dissected from the 1-week, 5-week and 9-week diabetic rats and the age-matched controls. 1H NMR-based metabonomics combined with multivariate pattern recognition analysis and quantitative analysis were used to study the metabolic characteristics. Results: The metabolic patterns of frontal lobe and occipital lobe were significantly changed in different stages of diabetes. Compared to the controls, lactate, taurine and myo-inositol were distinctly increased both in frontal lobe and occipital lobe with the development of diabetes, while the levels of N-acetyl-aspartate, aspartate and succinate were markedly decreased. Conclusion: The metabolic changes in frontal lobe and occipital lobe are similar, and occurr in the early stage of diabetes. The metabolic changes mainly focus around the disordered energy metabolism, inhibit Glu-Gln-GABA cycle and increas osmoregulation.

Key words： diabetes mellitus energy metabolism frontal lobe occipital lobe 1H NMR rats

Received: 17 May 2016

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	WANG Dan
	ZHENG Yongquan
	ZHAO Liangcai
	ZHENG Hong
	GAO Hongchang
	ZHANG Huajie.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I2/90

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