丽水市出生缺陷影响因素的病例对照研究

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Abstract Objective: To investigate the risk factors of birth defects in Lishui city, and to provide scientific evidence for intervention. Methods: A 1:3 case-control study was conducted, 601 mothers of infants with birth defects and 1803 controls were investigated retrospectively. Risk factors were analyzed by multivariate Logistic regression. Results: The incidence of birth defects was 29.79‰, the former five types of birth defects were congenital heart disease, polydactyly, cleft lip, syndactyly and, microtia. Logistic regression showed that maternal age (OR=3.752, 95%CI: 1.247-11.293, P=0.019), the health condition in the first trimester of pregnancy (OR= 2.997, 95%CI: 1.084-8.287, P=0.034), smoking or passive smoking during pregnancy (OR=2.205, 95%CI: 1.088-4.470, P=0.028), exposure to toxic factors during pregnancy (OR=3.582, 95%CI: 2.071-4.983, P=0.047), and face-painting, dying fingernails and dying hair in pregnancy (OR=3.659, 95%CI: 2.064-6.488, P<0.001) were the risk factors. Conclusion: Maternal age, the health condition in the first trimester of pregnancy, smoking or passive smoking during pregnancy, exposure to toxic factors in pregnancy, and face-painting, dying fingernails and dying the hair in pregnancy are the risk factors of birth defects.

Key words： congenital abnormalities perinatal case-control studies risk factors

Received: 18 January 2016

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	ZHANG Yali
	LAN Juhong
	LYU Zhuochao
	XIAO Lihua

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I1/56

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