多发性硬化患者的疲劳状况及其影响因素

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Abstract Objective: To study fatigue condition and discuss its influencing factors in multiple sclerosis (MS) patients. Methods: The modified fatigue impact scale (MFIS), data of disease-related factors and general profile registration form were used to conduct a face-to-face questionnaire investigation in 99 MS patients to collect demographic characteristics, MS-related information, fatigue degree, depression degree, impacts on quality of life (QOL) and other clinical data. SPSS15.0 software was then used for statistical analysis of the influencing factors. Results: Gender, age and relapse amount showed no statistical correlation with occurrence of fatigue (P>0.05); three variables, including disease course, disability level and depression degree were independently correlated with occurrence of fatigue. The fatigue occurrence in patients with a disease course of 5-10 years is 4.76 times of that in patients with a disease course≤5 years; the fatigue occurrence in moderately and severely disabled patients was 10.81 times of that in mildly disabled patients; and the occurrence of fatigue increases for 2.32 times if the depression degree increases for one scale. With respect to QOL, scores of both physical and psychological symptoms in patients with fatigue were higher than those in patients without fatigue, showing statistically significant differences (P<0.01). Conclusion: MS patients with long disease course, disability and severe depression degree have severer fatigue and fatigue poses obvious impacts on QOL. Disease course, disability level and depression degree are all influencing factors for MS-related fatigue.

Key words： multiple sclerosis fatigue quality of life depression

Received: 05 April 2016

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	CHEN Kelong
	FAN Yongping.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I1/52

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