氧化型低密度脂蛋白与川崎病冠状动脉损害的相关性

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Abstract Objective: To observe the expression of plasma oxidized low-density lipoprotein (oxLDL) in children with Kawasaki disease and to analyze the correlation of oxLDL with coronary artery lesions. Methods: Sixty cases diagnosed as Kawasaki disease (KD group) were divided into coronary artery lesion group (CAL group) and non-coronary artery lesion group (NCAL group) based on two-dimensional echocardiography. The venous blood was collected in acute stage and sub-acute stage (one week after the use of intravenous immunoglobulin). Twenty healthy controls and twenty fever control were enrolled into the study, and their venous blood was collected. Oxidized low- density liprproteins (oxLDL) was measured with enzyme linked immunosorbent assay (ELISA). Results: Compared with normal control group and fever control group, plasma oxLDL levels were higher in children with Kawasaki disease, whether acute or sub-acute, the difference was statistically significant (P<0.05). After the use of intravenous immunoglobulin plasma oxLDL levels have decreased, but the difference was not statistically significant compared with the acute stage (P>0.05). Compared with non-coronary artery lesion group, plasma oxLDL levels were significantly higher in coronary artery lesion group (P<0.05). Conclusion: Oxidized LDL plays an important role in the coronary artery sustained damage, the high-dose intravenous immunoglobulin can not completely relieve endothelial dysfunction in Kawasaki disease.

Key words： Kawasaki disease coronary artery lesion oxidized low-density liprproteins gamma-globulins

Received: 27 June 2016

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	HE Yuee
	CHU Maoping
	ZHANG Yuanhai
	WU Rongzhou
	XIANG Rulian.

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https://xb.wmu.edu.cn/EN/ OR https://xb.wmu.edu.cn/EN/Y2017/V47/I1/19

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